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Background: Accurate deformable image registration (DIR) is required for contour propagation and dose accumulation in MR-guided adaptive radiotherapy (MRgART). This study trained and evaluated a deep learning DIR method for domain invariant…

Purpose: Deformable Image Registration (DIR) can benefit from additional guidance using corresponding landmarks in the images. However, the benefits thereof are largely understudied, especially due to the lack of automatic landmark…

Computer Vision and Pattern Recognition · Computer Science 2023-02-28 Monika Grewal , Jan Wiersma , Henrike Westerveld , Peter A. N. Bosman , Tanja Alderliesten

Diffusion tensor cardiac magnetic resonance (DT-CMR) is a method capable of providing non-invasive measurements of myocardial microstructure. Image registration is essential to correct image shifts due to intra and inter breath-hold motion…

Image and Video Processing · Electrical Eng. & Systems 2024-05-17 Fanwen Wang , Pedro F. Ferreira , Yinzhe Wu , Camila Munoz , Ke Wen , Yaqing Luo , Jiahao Huang , Dudley J. Pennell , Andrew D. Scott , Sonia Nielles-Vallespin , Guang Yang

Deformable medical image registration is an essential task in computer-assisted interventions. This problem is particularly relevant to oncological treatments, where precise image alignment is necessary for tracking tumor growth, assessing…

Computer Vision and Pattern Recognition · Computer Science 2025-06-04 Stefano Fogarollo , Gregor Laimer , Reto Bale , Matthias Harders

Deformable image registration (DIR) is essential for many image-guided therapies. Recently, deep learning approaches have gained substantial popularity and success in DIR. Most deep learning approaches use the so-called mono-stream…

Image and Video Processing · Electrical Eng. & Systems 2020-12-08 Zhe Xu , Jie Luo , Jiangpeng Yan , Xiu Li , Jagadeesan Jayender

Regularization is essential in deformable image registration (DIR) to ensure that the estimated Deformation Vector Field (DVF) remains smooth, physically plausible, and anatomically consistent. However, fine-tuning regularization parameters…

Computer Vision and Pattern Recognition · Computer Science 2025-07-18 Sidaty El Hadramy , Oumeymah Cherkaoui , Philippe C. Cattin

Purpose: Deformable image registration (DIR) is critical in adaptive radiation therapy (ART) to account for anatomical changes. Conventional intensity-based DIR methods often fail when image intensities differ. This study evaluates a hybrid…

Medical Physics · Physics 2024-11-27 Keyur D. Shah , James A. Shackleford , Nagarajan Kandasamy , Gregory C. Sharp

Multimodal image registration (MIR) is a fundamental procedure in many image-guided therapies. Recently, unsupervised learning-based methods have demonstrated promising performance over accuracy and efficiency in deformable image…

Computer Vision and Pattern Recognition · Computer Science 2020-11-13 Zhe Xu , Jiangpeng Yan , Jie Luo , Xiu Li , Jayender Jagadeesan

Image registration, the process of aligning two or more images, is the core technique of many (semi-)automatic medical image analysis tasks. Recent studies have shown that deep learning methods, notably convolutional neural networks…

Computer Vision and Pattern Recognition · Computer Science 2021-09-09 Bob D. de Vos , Floris F. Berendsen , Max A. Viergever , Hessam Sokooti , Marius Staring , Ivana Isgum

Purpose: This study aims to explore training strategies to improve convolutional neural network-based image-to-image deformable registration for abdominal imaging. Methods: Different training strategies, loss functions, and transfer…

Image and Video Processing · Electrical Eng. & Systems 2023-02-28 Javier Pérez de Frutos , André Pedersen , Egidijus Pelanis , David Bouget , Shanmugapriya Survarachakan , Thomas Langø , Ole-Jakob Elle , Frank Lindseth

Purpose: Radiotherapy presents unique challenges and clinical requirements for longitudinal tumor and organ-at-risk (OAR) prediction during treatment. The challenges include tumor inflammation/edema and radiation-induced changes in organ…

Computer Vision and Pattern Recognition · Computer Science 2021-09-01 Donghoon Lee , Sadegh R Alam , Jue Jiang , Pengpeng Zhang , Saad Nadeem , Yu-Chi Hu

This study investigates the use of the unsupervised deep learning framework VoxelMorph for deformable registration of longitudinal abdominopelvic CT images acquired in patients with bone metastases from breast cancer. The CT images were…

Deformable medical image registration plays an important role in clinical diagnosis and treatment. Recently, the deep learning (DL) based image registration methods have been widely investigated and showed excellent performance in…

Image and Video Processing · Electrical Eng. & Systems 2022-10-18 Yibo Wang , Wen Qian , Xuming Zhang

We present deformable unsupervised medical image registration using a randomly-initialized deep convolutional neural network (CNN) as regularization prior. Conventional registration methods predict a transformation by minimizing…

Image and Video Processing · Electrical Eng. & Systems 2019-08-05 Max-Heinrich Laves , Sontje Ihler , Tobias Ortmaier

In this work we propose a deep learning network for deformable image registration (DIRNet). The DIRNet consists of a convolutional neural network (ConvNet) regressor, a spatial transformer, and a resampler. The ConvNet analyzes a pair of…

Computer Vision and Pattern Recognition · Computer Science 2017-12-08 Bob D. de Vos , Floris F. Berendsen , Max A. Viergever , Marius Staring , Ivana Išgum

Whole-body Positron Emission Tomography (PET) registration is essential for multi-parametric tumor characterization and assessment of metastatic disease progression. In deep learning-based deformable registration, the dense displacement…

Image and Video Processing · Electrical Eng. & Systems 2026-04-28 Xiangcen Wu , Ruohua Chen , Sichun Li , Qianye Yang , Sheng Liu , Jianjun Liu , Zhaoheng Xie

Radiation therapy presents a need for dynamic tracking of a target tumor volume. Fiducial markers such as implanted gold seeds have been used to gate radiation delivery but the markers are invasive and gating significantly increases…

Computer Vision and Pattern Recognition · Computer Science 2019-09-27 Markus D. Foote , Blake E. Zimmerman , Amit Sawant , Sarang Joshi

Deformable image registration (DIR) involves optimization of multiple conflicting objectives, however, not many existing DIR algorithms are multi-objective (MO). Further, while there has been progress in the design of deep learning…

Image and Video Processing · Electrical Eng. & Systems 2024-02-27 Monika Grewal , Henrike Westerveld , Peter A. N. Bosman , Tanja Alderliesten

Deformable registration continues to be one of the key challenges in medical image analysis. While iconic registration methods have started to benefit from the recent advances in medical deep learning, the same does not yet apply for the…

Computer Vision and Pattern Recognition · Computer Science 2019-09-18 Lasse Hansen , Doris Dittmer , Mattias P. Heinrich

Diffeomorphic image registration, offering smooth transformation and topology preservation, is required in many medical image analysis tasks.Traditional methods impose certain modeling constraints on the space of admissible transformations…

Computer Vision and Pattern Recognition · Computer Science 2022-11-03 Kun Han , Shanlin sun , Xiangyi Yan , Chenyu You , Hao Tang , Junayed Naushad , Haoyu Ma , Deying Kong , Xiaohui Xie