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While modern biotechnologies allow synthesizing new proteins and function measurements at scale, efficiently exploring a protein sequence space and engineering it remains a daunting task due to the vast sequence space of any given protein.…

Biomolecules · Quantitative Biology 2024-01-15 Jiahao Qiu , Hui Yuan , Jinghong Zhang , Wentao Chen , Huazheng Wang , Mengdi Wang

In this paper, we propose an effective search procedure that interleaves two steps: subproblem generation and subproblem solution. We mainly focus on the first part. It consists of a variable domain value ranking based on reduced costs.…

Artificial Intelligence · Computer Science 2007-05-23 M. Milano , W. J. van Hoeve

Distributed algorithms for solving coupled semidefinite programs (SDPs) commonly require many iterations to converge. They also put high computational demand on the computational agents. In this paper we show that in case the coupled…

Optimization and Control · Mathematics 2015-04-30 Sina Khoshfetrat Pakazad , Anders Hansson , Martin S. Andersen , Anders Rantzer

A focused crawler aims at discovering as many web pages and web sites relevant to a target topic as possible, while avoiding irrelevant ones. Reinforcement Learning (RL) has been a promising direction for optimizing focused crawling,…

Information Retrieval · Computer Science 2025-05-20 Andreas Kontogiannis , Dimitrios Kelesis , Vasilis Pollatos , George Giannakopoulos , Georgios Paliouras

The \emph{maximum a posteriori} (MAP) assignment for general structure Markov random fields (MRFs) is computationally intractable. In this paper, we exploit tree-based methods to efficiently address this problem. Our novel method, named…

Artificial Intelligence · Computer Science 2014-07-23 Truyen Tran , Dinh Phung , Svetha Venkatesh

Applying local search algorithms to combinatorial optimization problems is not an easy feat. Typically, human intervention is required to compile the constraints to input data for some metaheuristic algorithm. In this paper, we establish a…

Artificial Intelligence · Computer Science 2026-05-20 Jo Devriendt , Patrick De Causmaecker , Marc Denecker

Many popular algorithms for searching the space of leaf-labelled trees are based on tree rearrangement operations. Under any such operation, the problem is reduced to searching a graph where vertices are trees and (undirected) edges are…

Data Structures and Algorithms · Computer Science 2020-07-27 Lena Collienne , Alex Gavryushkin

Nearest neighbor search is a fundamental data structure problem with many applications in machine learning, computer vision, recommendation systems and other fields. Although the main objective of the data structure is to quickly report…

Data Structures and Algorithms · Computer Science 2025-02-20 Piyush Anand , Piotr Indyk , Ravishankar Krishnaswamy , Sepideh Mahabadi , Vikas C. Raykar , Kirankumar Shiragur , Haike Xu

The multi-modal nature of many vision problems calls for neural network architectures that can perform multiple tasks concurrently. Typically, such architectures have been handcrafted in the literature. However, given the size and…

Computer Vision and Pattern Recognition · Computer Science 2021-05-12 David Bruggemann , Menelaos Kanakis , Stamatios Georgoulis , Luc Van Gool

We present a method to apply heuristic search algorithms to solve rearrangement planning by pushing problems. In these problems, a robot must push an object through clutter to achieve a goal. To do this, we exploit the fact that contact…

Robotics · Computer Science 2016-03-30 Jennifer E. King , Siddhartha S. Srinivasa

Querying the shortest path between two vertexes is a fundamental operation in a variety of applications, which has been extensively studied over static road networks. However, in reality, the travel costs of road segments evolve over time,…

Databases · Computer Science 2023-03-08 Zengyang Gong , Yuxiang Zeng , Lei Chen

Contemporary accelerator designs exhibit a high degree of spatial localization, wherein two-dimensional physical distance determines communication costs between processing elements. This situation presents considerable algorithmic…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-08-09 Yves Baumann , Tal Ben-Nun , Maciej Besta , Lukas Gianinazzi , Torsten Hoefler , Piotr Luczynski

Tree data structures, such as red-black trees, quad trees, treaps, or tries, are fundamental tools in computer science. A classical problem in concurrency is to obtain expressive, efficient, and scalable versions of practical tree data…

Databases · Computer Science 2023-10-10 Ilya Kokorin , Dan Alistarh , Vitaly Aksenov

Over the last 10 to 15 years, active inference has helped to explain various brain mechanisms from habit formation to dopaminergic discharge and even modelling curiosity. However, the current implementations suffer from an exponential…

Artificial Intelligence · Computer Science 2022-04-13 Théophile Champion , Lancelot Da Costa , Howard Bowman , Marek Grześ

Variable neighborhood search (VNS) is a metaheuristic for solving optimization problems based on a simple principle: systematic changes of neighborhoods within the search, both in the descent to local minima and in the escape from the…

Artificial Intelligence · Computer Science 2011-09-16 Martin Josef Geiger , Marc Sevaux , Stefan Voss

This monograph takes a step towards promoting the study of efficiency in the era of neural information retrieval by offering a comprehensive survey of the literature on efficiency and effectiveness in ranking, and to a limited extent,…

Information Retrieval · Computer Science 2023-05-22 Sebastian Bruch , Claudio Lucchese , Franco Maria Nardini

We introduce a search problem generalizing the typical setting of Binary Search on the line. Similar to the setting for Binary Search, a target is chosen adversarially on the line, and in response to a query, the algorithm learns whether…

Data Structures and Algorithms · Computer Science 2023-03-14 Calvin Leng , David Kempe

We consider the following generalization of the binary search problem. A search strategy is required to locate an unknown target node $t$ in a given tree $T$. Upon querying a node $v$ of the tree, the strategy receives as a reply an…

Data Structures and Algorithms · Computer Science 2017-02-28 Dariusz Dereniowski , Adrian Kosowski , Przemyslaw Uznanski , Mengchuan Zou

The dynamic trees problem is to maintain a forest subject to edge insertions and deletions while facilitating queries such as connectivity, path weights, and subtree weights. Dynamic trees are a fundamental building block of a large number…

Data Structures and Algorithms · Computer Science 2020-10-27 Umut A. Acar , Daniel Anderson , Guy E. Blelloch , Laxman Dhulipala , Sam Westrick

For a graph $G$, the parameter treedepth measures the minimum depth among all forests $F$, called elimination forests, such that $G$ is a subgraph of the ancestor-descendant closure of $F$. We introduce a logic, called neighborhood operator…

Data Structures and Algorithms · Computer Science 2025-10-23 Benjamin Bergougnoux , Vera Chekan , Giannos Stamoulis
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