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Imaging genetics aims to uncover the hidden relationship between imaging quantitative traits (QTs) and genetic markers (e.g. single nucleotide polymorphism (SNP)), and brings valuable insights into the pathogenesis of complex diseases, such…

Methodology · Statistics 2025-04-30 Zhibin Pu , Shufei Ge

We consider the problem of verifying stochastic models of biochemical networks against behavioral properties expressed in temporal logic terms. Exact probabilistic verification approaches such as, for example, CSL/PCTL model checking, are…

Computational Engineering, Finance, and Science · Computer Science 2009-12-15 Paolo Ballarini , Michele Forlin , Tommaso Mazza , Davide Prandi

Transcriptome-wide association studies (TWAS) are powerful tools for identifying gene-level associations by integrating genome-wide association studies and gene expression data. However, most TWAS methods focus on linear associations…

Methodology · Statistics 2024-12-10 Tianying Wang , Iuliana Ionita-Laza , Ying Wei

Gene expression is a readily-observed quantification of transcriptional activity and cellular state that enables the recovery of the relationships between regulators and their target genes. Reconstructing transcriptional regulatory networks…

Molecular Networks · Quantitative Biology 2016-09-22 Anthony Gitter , Furong Huang , Ragupathyraj Valluvan , Ernest Fraenkel , Animashree Anandkumar

Molecular Relational Learning (MRL), aiming to understand interactions between molecular pairs, plays a pivotal role in advancing biochemical research. Recently, the adoption of large language models (LLMs), known for their vast knowledge…

Quantitative Methods · Quantitative Biology 2024-06-11 Junfeng Fang , Shuai Zhang , Chang Wu , Zhengyi Yang , Zhiyuan Liu , Sihang Li , Kun Wang , Wenjie Du , Xiang Wang

Multi-task learning (MTL) has achieved great success in various research domains, such as CV, NLP and IR etc. Due to the complex and competing task correlation, naive training all tasks may lead to inequitable learning, i.e. some tasks are…

Machine Learning · Computer Science 2023-06-21 Jun Yuan , Rui Zhang

Multi-task learning (MTL) is useful for domains in which data originates from multiple sources that are individually under-sampled. MTL methods are able to learn classification models that have higher performance as compared to learning a…

Computer Vision and Pattern Recognition · Computer Science 2016-08-02 Bilal Ahmed , Thomas Thesen , Karen E. Blackmon , Ruben Kuzniecky , Orrin Devinsky , Jennifer G. Dy , Carla E. Brodley

Multi-task learning (MTL) trains deep neural networks to optimize several objectives simultaneously using a shared backbone, which leads to reduced computational costs, improved data efficiency, and enhanced performance through cross-task…

Machine Learning · Computer Science 2025-09-30 Hoang Phan , Lam Tran , Quyen Tran , Ngoc N. Tran , Tuan Truong , Qi Lei , Nhat Ho , Dinh Phung , Trung Le

In an empirical Bayesian setting, we provide a new multiple testing method, useful when an additional covariate is available, that influences the probability of each null hypothesis being true. We measure the posterior significance of each…

Applications · Statistics 2008-07-30 Egil Ferkingstad , Arnoldo Frigessi , Håvard Rue , Gudmar Thorleifsson , Augustine Kong

In order to deal with the systematic verification with uncertain infromation in possibility theory, Li and Li \cite{li12} introduced model checking of linear-time properties in which the uncertainty is modeled by possibility measures. Xue,…

Logic in Computer Science · Computer Science 2014-01-21 Yongming Li , Yali Li , Zhanyou Ma

Our work is motivated by and illustrated with application of association networks in computational biology, specifically in the context of gene/protein regulatory networks. Association networks represent systems of interacting elements,…

Applications · Statistics 2012-05-01 Natallia Katenka , Eric D. Kolaczyk

Biological networks are one of the most studied object in computational biology. Several methods have been developed for studying qualitative properties of biological networks. Last decade had seen the improvement of molecular techniques…

Quantitative Methods · Quantitative Biology 2016-08-14 Jérémie Bourdon , Damien Eveillard

Impulsive noise poses a significant challenge to the reliability of wireless communication systems, necessitating accurate estimation of its statistical parameters for effective mitigation. This paper introduces a multitask learning (MTL)…

Signal Processing · Electrical Eng. & Systems 2025-10-15 Abdullahi Mohammad , Bdah Eya , Bassant Selim

Exploring the genetic basis of heritable traits remains one of the central challenges in biomedical research. In simple cases, single polymorphic loci explain a significant fraction of the phenotype variability. However, many traits of…

Populations and Evolution · Quantitative Biology 2015-03-20 Barbara Rakitsch , Christoph Lippert , Oliver Stegle , Karsten Borgwardt

We propose \textbf{Cognitive Load Traces} (CLTs) as a mid-level interpretability framework for deep models, inspired by Cognitive Load Theory in human cognition. CLTs are defined as symbolic, temporally varying functions that quantify…

Artificial Intelligence · Computer Science 2025-10-21 Dong Liu , Yanxuan Yu

Gene expression levels in a population vary extensively across tissues. Such heterogeneity is caused by genetic variability and environmental factors, and is expected to be linked to disease development. The abundance of experimental data…

Machine Learning · Statistics 2015-06-26 Zi Wang , Wei Yuan , Giovanni Montana

Cross-subject variability in EEG degrades performance of current deep learning models, limiting the development of brain-computer interface (BCI). This paper proposes ISAM-MTL, which is a multi-task learning (MTL) EEG classification model…

Neural and Evolutionary Computing · Computer Science 2025-01-31 Junyan Li , Bin Hu , Zhi-Hong Guan

Multi-Task Learning (MTL) is a learning paradigm in machine learning and its aim is to leverage useful information contained in multiple related tasks to help improve the generalization performance of all the tasks. In this paper, we give a…

Machine Learning · Computer Science 2021-03-30 Yu Zhang , Qiang Yang

In the classic view introduced by R. A. Fisher, a quantitative trait is encoded by many loci with small, additive effects. Recent advances in QTL mapping have begun to elucidate the genetic architectures underlying vast numbers of…

Populations and Evolution · Quantitative Biology 2013-10-04 Etienne Rajon , Joshua B. Plotkin

To efficiently select optimal dataset combinations for enhancing multi-task learning (MTL) performance in large language models, we proposed a novel framework that leverages a neural network to predict the best dataset combinations. The…

Computation and Language · Computer Science 2025-05-06 Zaifu Zhan , Rui Zhang