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One of the central problems in epigenetics is how epigenetic modification patterns and chromatin structure are regulated in the cell nucleus. The polymer Potts model, a recently studied model of chromatins, is introduced with an offset in…

Soft Condensed Matter · Physics 2025-05-13 Ryo Nakanishi , Koji Hukushima

The previously published data are examined on the base of the hypothesis about existence of differential polyteny of chromosomes and excess chromatin diminution during the first stages of embryogenesis. It has been concluded that available…

Other Quantitative Biology · Quantitative Biology 2014-01-03 Evgenii Vladimirovich Levites

Epigenetics is a driving force of important and ubiquitous phenomena in nature such as cell differentiation or even metamorphosis. Oppositely to its widespread role, understanding the biophysical principles that allow epigenetics to control…

Soft Condensed Matter · Physics 2020-01-08 Davide Colì , Davide Michieletto , Davide Marenduzzo , Enzo Orlandini

We consider a system of clusters made of elementary building blocks, monomers, and evolving via collisions between diffusing monomers and immobile composite clusters. In our model, the cluster-monomer collision can lead to the attachment of…

Statistical Mechanics · Physics 2017-10-25 P. L. Krapivsky , W. Otieno , N. V. Brilliantov

The genetic instructions stored in the genome require an additional layer of information to robustly determine cell fate. This additional regulation is provided by the interplay between chromosome-patterning biochemical ("epigenetic") marks…

Soft Condensed Matter · Physics 2019-12-04 Davide Coli , Davide Michieletto , Davide Marenduzzo , Enzo Orlandini

The spreading and regulation of epigenetic marks on chromosomes is crucial to establish and maintain cellular identity. Nonetheless, the dynamical mechanism leading to the establishment and maintenance of a given, cell-line specific,…

Soft Condensed Matter · Physics 2017-11-08 Davide Michieletto , Enzo Orlandini , Davide Marenduzzo

In $d > 2$ dimensional, homogeneous threshold models discontinuous transition occur, but the mean-field solution provides $1/t$ power-law activity decay and other power-laws, thus it is called mixed-order or hybrid type. It has recently…

Disordered Systems and Neural Networks · Physics 2021-02-10 Géza Ódor , Beatriz de Simoni

Hybridization between species is an important mechanism for the origin of novel lineages and adaptation to new environments. Increased allelic variation and modification of the transcriptional network are the two recognized forces currently…

Genomics · Quantitative Biology 2013-10-24 Elzbieta M. Piatkowska , David Knight , Daniela Delneri

We consider here a blend made of two types of polymers, $A$ and $B$, of different chemical nature. At high temperature the homogeneous mixture is cross-linked. As the temperature is lowered, the two species try to segregate but are kept…

Condensed Matter · Physics 2015-06-25 Edilson Vargas , Marcia C. Barbosa

We develop a model for speciation due to postzygotic incompatibility generated by autoimmune reactions. The model is based on predator-prey interactions between a host plants and their pathogens. Such interactions are often…

Populations and Evolution · Quantitative Biology 2010-11-02 I. Ispolatov , Michael Doebeli

The Flory-Huggins theory is a well-established lattice model that is commonly used to study the mixing of distinct chemical species. It can successfully predict phase separation phenomena in blends of incompatible materials. However, it is…

Materials Science · Physics 2025-12-19 Maxime Siber , Olivier J. J. Ronsin , Jens Harting

While the thermodynamics of DNA hybridization is well understood, much less is known about the kinetics of this classic system. Filling this gap in our understanding has new urgency because DNA nanotechnology often depends critically on…

Soft Condensed Matter · Physics 2013-10-28 Thomas E. Ouldridge , Petr Šulc , Flavio Romano , Jonathan P. K. Doye , Ard A. Louis

The phase behavior of a cross-linked polymer blend made of two incompatible species, $A$ and $B$, of different chemical nature is analyzed. Besides a homogeneous phase, this system also exhibits two microphases and a phase of total…

Condensed Matter · Physics 2007-05-23 Edilson Vargas , Marcia C. Barbosa

Genes linked to X or Z chromosomes, which are hemizygous in the heterogametic sex, are predicted to evolve at different rates than those on autosomes. This faster-X effect can arise either as a consequence of hemizygosity, which leads to…

Populations and Evolution · Quantitative Biology 2014-06-10 Timothy B. Sackton , Russell B. Corbett-Detig , Javaregowda Nagaraju , R. Lakshmi Vaishna , Kallare P. Arunkumar , Daniel L. Hartl

Controllable topological phase transitions are appealing as they allow for tunable single particle electronic properties. Here, by using state-of-the-art manybody perturbation theory techniques, we show that the topological $Z_2$ phase…

Mesoscale and Nanoscale Physics · Physics 2022-10-13 Davide Romanin , Matteo Calandra , Alex W. Chin

Variation in the evolutionary process across the sites of nucleotide sequence alignments is well established, and is an increasingly pervasive feature of datasets composed of gene regions sampled from multiple loci and/or different genomes.…

Populations and Evolution · Quantitative Biology 2014-09-04 Brian R. Moore , Jim McGuire , Fredrik Ronquist , John P. Huelsenbeck

Horizontal gene transfer (HGT) is an important process in bacterial evolution. Current phylogeny-based approaches to capture it cannot however appropriately account for the fact that HGT can occur between bacteria living in different…

Populations and Evolution · Quantitative Biology 2025-03-31 Katharina T. Huber , Darren Overman

It has been demonstrated that the observed ratio of phenotypes of marker enzymes in some sugarbeet plants produced by mitotic agamospermy can be explained by different degrees of endoreduplication of chromosomes carrying different alleles…

Genomics · Quantitative Biology 2007-05-23 Evgenii V. Levites

Phagocytosis is the fundamental cellular process by which eukaryotic cells bind and engulf particles by their cell membrane. Particle engulfment involves particle recognition by cell-surface receptors, signaling and remodeling of the actin…

Cell Behavior · Quantitative Biology 2010-11-02 Sylvain Tollis , Anna E. Dart , George Tzircotis , Robert G. Endres

Biological mixtures such as the cytosol may consist of thousands of distinct components. There is now a substantial body of evidence showing that, under physiological conditions, intracellular mixtures can phase separate into spatially…

Soft Condensed Matter · Physics 2017-03-06 William M. Jacobs , Daan Frenkel
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