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While measurement advances now allow extensive surveys of gene activity (large numbers of genes across many samples), interpretation of these data is often confounded by noise -- expression counts can differ strongly across samples due to…

The environment plays a critical role in galaxy evolution, with galaxy clusters and their infall regions offering diverse conditions that shape galaxies before they enter the dense cluster core, a process known as ``pre-processing''.…

Astrophysics of Galaxies · Physics 2026-05-15 Rhys Jordan , Meghan E. Gray , Alfonso Aragón-Salamanca , Steven P. Bamford , Frazer R. Pearce , Roan Haggar

Modern high throughput sequencing technologies like metagenomic sequencing generate millions of sequences which have to be classified based on their taxonomic rank. Modern approaches either apply local alignment and comparison to existing…

Genomics · Quantitative Biology 2023-03-14 Wolfgang Fuhl , Susanne Zabel , Kay Nieselt

A major bottleneck in search-based program synthesis is the exponentially growing search space which makes learning large programs intractable. Humans mitigate this problem by leveraging the compositional nature of the real world: In…

Artificial Intelligence · Computer Science 2024-12-25 Jonas Witt , Sebastijan Dumančić , Tias Guns , Claus-Christian Carbon

Large monolithic generative models trained on massive amounts of data have become an increasingly dominant approach in AI research. In this paper, we argue that we should instead construct large generative systems by composing smaller…

Machine Learning · Computer Science 2024-06-05 Yilun Du , Leslie Kaelbling

Autonomous bin picking poses significant challenges to vision-driven robotic systems given the complexity of the problem, ranging from various sensor modalities, to highly entangled object layouts, to diverse item properties and gripper…

Computer Vision and Pattern Recognition · Computer Science 2022-08-09 Maximilian Gilles , Yuhao Chen , Tim Robin Winter , E. Zhixuan Zeng , Alexander Wong

In the small phylogeny problem we, are given a phylogenetic tree and gene orders of the extant species and our goal is to reconstruct all of the ancestral genomes so that the number of evolutionary operations is minimized. Algorithms for…

Populations and Evolution · Quantitative Biology 2015-03-17 Jakub Kováč , Broňa Brejová , Tomáš Vinař

Predicting the effect of mutations in proteins is one of the most critical challenges in protein engineering; by knowing the effect a substitution of one (or several) residues in the protein's sequence has on its overall properties, could…

Computational Engineering, Finance, and Science · Computer Science 2020-10-08 David Medina-Ortiz , Sebastian Contreras , Juan Amado-Hinojosa , Jorge Torres-Almonacid , Juan A. Asenjo , Marcelo Navarrete , Álvaro Olivera-Nappa

Matrix decomposition is one of the fundamental tools to discover knowledge from big data generated by modern applications. However, it is still inefficient or infeasible to process very big data using such a method in a single machine.…

Machine Learning · Computer Science 2020-02-11 Chihao Zhang , Yang Yang , Wei Zhang , Shihua Zhang

Until recently, deep steganalyzers in spatial domain have been all designed for gray-scale images. In this paper, we propose WISERNet (the wider separate-then-reunion network) for steganalysis of color images. We provide theoretical…

Multimedia · Computer Science 2019-03-15 Jishen Zeng , Shunquan Tan , Guangqing Liu , Bin Li , Jiwu Huang

Deep learning has revolutionized many industries by enabling models to automatically learn complex patterns from raw data, reducing dependence on manual feature engineering. However, deep learning algorithms are sensitive to input data, and…

Machine Learning · Computer Science 2025-07-21 Mert Sehri , Zehui Hua , Francisco de Assis Boldt , Patrick Dumond

The problem of assembling DNA fragments starting from imperfect strings given by a sequencer, classified as NP hard when trying to get perfect answers, has a huge importance in several fields, because of its relation with the possibility of…

Data Structures and Algorithms · Computer Science 2017-05-26 Juan Manuel Ciro Restrepo , Andrés Felipe Zapata Palacio , Mauricio Toro

Modern semantic parsers suffer from two principal limitations. First, training requires expensive collection of utterance-program pairs. Second, semantic parsers fail to generalize at test time to new compositions/structures that have not…

Computation and Language · Computer Science 2021-09-07 Inbar Oren , Jonathan Herzig , Jonathan Berant

Computerized Tomography assembly and system configuration are optimized for enhanced invertibility in sparse data reconstruction. Assembly generating maximum principal components/condition number of weight matrix is designated as best…

Instrumentation and Detectors · Physics 2023-10-02 Mayank Goswami

We propose a novel numerical approach for the optimal design of wide-area heterogeneous electromagnetic metasurfaces beyond the conventionally used unit-cell approximation. The proposed method exploits the combination of Rigorous Coupled…

Applied Physics · Physics 2017-09-19 Krupali D. Donda , Ravi S. Hegde

DNA-coated particles are promising as building blocks for functional and finite-sized assemblies because they can be programmed with orthogonal interactions owing to the sequence-specific hybridization of DNA strands. To fully exploit this…

Soft Condensed Matter · Physics 2026-04-17 T. C. M. Stevens , A. van der Sluis , I. K. Voets , P. G. Moerman

By combining metal nodes with organic linkers we can potentially synthesize millions of possible metal organic frameworks (MOFs). At present, we have libraries of over ten thousand synthesized materials and millions of in-silico predicted…

Materials Science · Physics 2020-06-12 Kevin Maik Jablonka , Daniele Ongari , Seyed Mohamad Moosavi , Berend Smit

Next-generation sequencing technologies have enhanced the scope of Internet-of-Things (IoT) to include genomics for personalized medicine through the increased availability of an abundance of genome data collected from heterogeneous sources…

Clustering techniques are very attractive for extracting and identifying patterns in datasets. However, their application to very large spatial datasets presents numerous challenges such as high-dimensionality data, heterogeneity, and high…

Databases · Computer Science 2018-02-27 Malika Bendechache , Nhien-An Le-Khac , M-Tahar Kechadi

Motivation: The availability of thousands of invidual genomes of one species should boost rapid progress in personalized medicine or understanding of the interaction between genotype and phenotype, to name a few applications. A key…

Computational Engineering, Finance, and Science · Computer Science 2017-03-03 Agnieszka Danek , Sebastian Deorowicz , Szymon Grabowski
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