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The human proteome contains a vast network of interacting kinases and substrates. Even though some kinases have proven to be immensely useful as therapeutic targets, a majority are still understudied. In this work, we present a novel…

Quantitative Methods · Quantitative Biology 2022-06-13 Sachin Gavali , Karen Ross , Chuming Chen , Julie Cowart , Cathy H. Wu

We propose a method for gene expression based analysis of cancer phenotypes incorporating network biology knowledge through unsupervised construction of computational graphs. The structural construction of the computational graphs is driven…

Molecular Networks · Quantitative Biology 2020-10-02 Paul Scherer , Maja Trȩbacz , Nikola Simidjievski , Zohreh Shams , Helena Andres Terre , Pietro Liò , Mateja Jamnik

Session-based recommendation (SBR) focuses on next-item prediction at a certain time point. As user profiles are generally not available in this scenario, capturing the user intent lying in the item transitions plays a pivotal role. Recent…

Information Retrieval · Computer Science 2022-03-01 Xin Xia , Hongzhi Yin , Junliang Yu , Qinyong Wang , Lizhen Cui , Xiangliang Zhang

Link prediction is a fundamental task in graph learning, inherently shaped by the topology of the graph. While traditional heuristics are grounded in graph topology, they encounter challenges in generalizing across diverse graphs. Recent…

Machine Learning · Computer Science 2024-06-18 Juzheng Zhang , Lanning Wei , Zhen Xu , Quanming Yao

Hypergraph neural networks (HGNNs) effectively model complex high-order relationships in domains like protein interactions and social networks by connecting multiple vertices through hyperedges, enhancing modeling capabilities, and reducing…

Machine Learning · Computer Science 2025-12-08 Yue Gao , Yifan Feng , Shiquan Liu , Xiangmin Han , Shaoyi Du , Zongze Wu , Han Hu

Existing unsupervised hash learning is a kind of attribute-centered calculation. It may not accurately preserve the similarity between data. This leads to low down the performance of hash function learning. In this paper, a hash algorithm…

Machine Learning · Computer Science 2022-06-07 Shichao Zhang , Jiaye Li

In this paper, we present a graph-based semi-supervised framework for hyperspectral image classification. We first introduce a novel superpixel algorithm based on the spectral covariance matrix representation of pixels to provide a better…

Computer Vision and Pattern Recognition · Computer Science 2019-05-16 Philip Sellars , Angelica Aviles-Rivero , Nicolas Papadakis , David Coomes , Anita Faul , Carola-Bibane Schönlieb

The goal in semi-supervised learning is to effectively combine labeled and unlabeled data. One way to do this is by encouraging smoothness across edges in a graph whose nodes correspond to input examples. In many graph-based methods, labels…

Machine Learning · Computer Science 2018-02-28 Nir Rosenfeld , Amir Globerson

We present a scalable approach for semi-supervised learning on graph-structured data that is based on an efficient variant of convolutional neural networks which operate directly on graphs. We motivate the choice of our convolutional…

Machine Learning · Computer Science 2017-02-23 Thomas N. Kipf , Max Welling

Graph model is emerging as a very effective tool for learning the complex structures and relationships hidden in data. Generally, the critical purpose of graph-oriented learning algorithms is to construct an informative graph for image…

Computer Vision and Pattern Recognition · Computer Science 2016-12-21 Qingshan Liu , Yubao Sun , Cantian Wang , Tongliang Liu , Dacheng Tao

Graphs as a type of data structure have recently attracted significant attention. Representation learning of geometric graphs has achieved great success in many fields including molecular, social, and financial networks. It is natural to…

Machine Learning · Computer Science 2021-07-08 Tian Xia , Wei-Shinn Ku

Gene interaction graphs aim to capture various relationships between genes and can represent decades of biology research. When trying to make predictions from genomic data, those graphs could be used to overcome the curse of dimensionality…

In many practical real-world applications, data missing is a very common phenomenon, making the development of data-driven artificial intelligence theory and technology increasingly difficult. Data completion is an important method for…

Machine Learning · Computer Science 2024-06-13 Xiaohua Pan , Weifeng Wu , Peiran Liu , Zhen Li , Peng Lu , Peijian Cao , Jianfeng Zhang , Xianfei Qiu , YangYang Wu

We present a method for finding hierarchy-aware embeddings of knowledge graphs (KGs) using graph neural networks (GNNs) enriched with a semantic loss derived from underlying ontologies. This method yields embeddings that better reflect…

Machine Learning · Computer Science 2026-05-21 Filip Kronström , Alexander H. Gower , Daniel Brunnsåker , Ievgeniia A. Tiukova , Ross D. King

In this paper, we propose an iterative framework, which consists of two phases: a generation phase and a training phase, to generate realistic training data and yield a supervised homography network. In the generation phase, given an…

Computer Vision and Pattern Recognition · Computer Science 2023-08-16 Hai Jiang , Haipeng Li , Songchen Han , Haoqiang Fan , Bing Zeng , Shuaicheng Liu

Graph-based semi-supervised learning is the problem of propagating labels from a small number of labelled data points to a larger set of unlabelled data. This paper is concerned with the consistency of optimization-based techniques for such…

Machine Learning · Statistics 2020-03-11 Franca Hoffmann , Bamdad Hosseini , Zhi Ren , Andrew M. Stuart

Motivation: Inferring the structure of gene regulatory networks from high--throughput datasets remains an important and unsolved problem. Current methods are hampered by problems such as noise, low sample size, and incomplete…

Quantitative Methods · Quantitative Biology 2017-12-04 Phan Nguyen , Rosemary Braun

Graph learning (GL) can dynamically capture the distribution structure (graph structure) of data based on graph convolutional networks (GCN), and the learning quality of the graph structure directly influences GCN for semi-supervised…

Computer Vision and Pattern Recognition · Computer Science 2020-06-01 Guangfeng Lin , Xiaobing Kang , Kaiyang Liao , Fan Zhao , Yajun Chen

This paper addresses theory and applications of $\ell_p$-based Laplacian regularization in semi-supervised learning. The graph $p$-Laplacian for $p>2$ has been proposed recently as a replacement for the standard ($p=2$) graph Laplacian in…

Numerical Analysis · Mathematics 2022-01-28 Mauricio Flores , Jeff Calder , Gilad Lerman

Predicting gene function from its DNA sequence is a fundamental challenge in biology. Many deep learning models have been proposed to embed DNA sequences and predict their enzymatic function, leveraging information in public databases…

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