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We analyze a class of chemical reaction networks under mass-action kinetics and involving multiple time-scales, whose deterministic and stochastic models display qualitative differences. The networks are inspired by gene-regulatory…

Molecular Networks · Quantitative Biology 2018-01-30 Tomislav Plesa , Radek Erban , Hans G. Othmer

Understanding the basic operational logics of the nervous system is essential to advancing neuroscientific research. However, theoretical efforts to tackle this fundamental problem are lacking, despite the abundant empirical data about the…

Neurons and Cognition · Quantitative Biology 2021-09-07 Cheng Qian

The early identification and intervention of latent depression are of significant societal importance for mental health governance. While current automated detection methods based on social media have shown progress, their decision-making…

Quantitative Methods · Quantitative Biology 2025-12-17 Junwei Kuang , Jiaheng Xie , Zhijun Yan

We study the impact of noise on a neural population rate model of up and down states. Up and down states are typically observed in neuronal networks as a slow oscillation, where the population switches between high and low firing rates…

Neurons and Cognition · Quantitative Biology 2015-04-24 Zachary McCleney , Zachary P. Kilpatrick

Automatic depression detection from doctor-patient conversations has gained momentum thanks to the availability of public corpora and advances in language modeling. However, interpretability remains limited: strong performance is often…

This work shows that depression changes the correlation between features extracted from speech. Furthermore, it shows that using such an insight can improve the training speed and performance of depression detectors based on SVMs and LSTMs.…

Computation and Language · Computer Science 2023-07-10 Fuxiang Tao , Wei Ma , Xuri Ge , Anna Esposito , Alessandro Vinciarelli

While most models of randomly connected networks assume nodes with simple dynamics, nodes in realistic highly connected networks, such as neurons in the brain, exhibit intrinsic dynamics over multiple timescales. We analyze how the…

Disordered Systems and Neural Networks · Physics 2019-09-11 Samuel P. Muscinelli , Wulfram Gerstner , Tilo Schwalger

The extraordinary computational power of the brain may be related in part to the fact that each of the smaller neural networks that compose it can behave transiently in many different ways, depending on its inputs. Mathematically, input…

Neurons and Cognition · Quantitative Biology 2008-03-29 Léonard Gérard , Jean-Jacques Slotine

Anatomic connections between brain areas affect information flow between neuronal circuits and the synchronization of neuronal activity. However, such structural connectivity does not coincide with effective connectivity, related to the…

Neurons and Cognition · Quantitative Biology 2015-06-03 Demian Battaglia , Annette Witt , Fred Wolf , Theo Geisel

In the paper we discuss the dynamics of the order parameter in complex networks with long-range space interactions and temporal memory and analyze phase transitions induced by noise in such systems.

Statistical Mechanics · Physics 2015-12-03 Bahruz Gadjiev , Tatiana Progulova , Sergey Timoshin

Intermittent transitions, associated with critical dynamics and characterized by power-law distributions, are commonly observed during sleep. These critical behaviors are evident at the microscopic level through neuronal avalanches and at…

Physics and Society · Physics 2025-03-28 Xiyun Zhang , Bojun Wang , Hongjie Bi

Noisy dynamical models are employed to describe a wide range of phenomena. Since exact modeling of these phenomena requires access to their microscopic dynamics, whose time scales are typically much shorter than the observable time scales,…

Statistical Mechanics · Physics 2015-11-18 Giovanni Volpe , Jan Wehr

Major Depressive Disorder (MDD) is a highly prevalent mental health condition, and a deeper understanding of its neurocognitive foundations is essential for identifying how core functions such as emotional and self-referential processing…

The behavior of recurrent neural network for the data-driven simulation of noisy dynamical systems is studied by training a set of Long Short-Term Memory Networks (LSTM) on the Mackey-Glass time series with a wide range of noise level. It…

Neural and Evolutionary Computing · Computer Science 2019-04-11 Kyongmin Yeo

The functional significance of correlations between action potentials of neurons is still a matter of vivid debates. In particular it is presently unclear how much synchrony is caused by afferent synchronized events and how much is…

Neurons and Cognition · Quantitative Biology 2013-04-09 Matthias Schultze-Kraft , Markus Diesmann , Sonja Grün , Moritz Helias

Spikes are the currency in central nervous systems for information transmission and processing. They are also believed to play an essential role in low-power consumption of the biological systems, whose efficiency attracts increasing…

Neural and Evolutionary Computing · Computer Science 2020-05-05 Qiang Yu , Shenglan Li , Huajin Tang , Longbiao Wang , Jianwu Dang , Kay Chen Tan

In continuous attractor neural networks (CANNs), spatially continuous information such as orientation, head direction, and spatial location is represented by Gaussian-like tuning curves that can be displaced continuously in the space of the…

Neurons and Cognition · Quantitative Biology 2015-09-23 He Wang , Kin Lam , C. C. Alan Fung , K. Y. Michael Wong , Si Wu

The counterintuitive emergence of order from noise is a central phenomenon in science, ranging from pattern formation and synchronization to order-by-disorder in frustrated systems. While large-scale spatial self-organization induced by…

Soft Condensed Matter · Physics 2026-02-02 Satyam Anand , Guanming Zhang , Stefano Martiniani

Synapses change on multiple timescales, ranging from milliseconds to minutes, due to a combination of both short- and long-term plasticity. Here we develop an extension of the common Generalized Linear Model to infer both short- and…

Neurons and Cognition · Quantitative Biology 2022-08-15 Ganchao Wei , Ian H. Stevenson

We report a detailed study of neuromorphic switching behaviour in inherently complex percolating networks of self-assembled metal nanoparticles. We show that variation of the strength and duration of the electric field applied to this…

Disordered Systems and Neural Networks · Physics 2019-03-06 S. K. Bose , S. Shirai , J. B. Mallinson , S. A. Brown