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Unbalanced translocations are among the most frequent chromosomal alterations, accounted for 30\% of all losses of heterozygosity, a major genetic event causing inactivation of tumor suppressor genes. Despite of their central role in…

Data Structures and Algorithms · Computer Science 2018-12-04 Domenico Cantone , Simone Faro , Arianna Pavone

Chance-constrained problems involve stochastic components in the constraints which can be violated with a small probability. We investigate the impact of different types of chance constraints on the performance of iterative search…

Neural and Evolutionary Computing · Computer Science 2024-05-30 Saba Sadeghi Ahouei , Jacob de Nobel , Aneta Neumann , Thomas Bäck , Frank Neumann

In the Monte Carlo (MC) method statistical noise is usually present. Statistical noise may become dominant in the calculation of a distribution, usually by iteration, but is less Important in calculating integrals. The subject of the…

Computational Physics · Physics 2013-11-08 Mihály Makai , Zoltán Szatmáry

We consider the problem of estimating the probability of an observed string drawn i.i.d. from an unknown distribution. The key feature of our study is that the length of the observed string is assumed to be of the same order as the size of…

Information Theory · Computer Science 2007-07-13 Aaron B. Wagner , Pramod Viswanath , Sanjeev R. Kulkarni

-The fluctuation effect of gradient expectation and variance caused by parameter update between consecutive iterations is neglected or confusing by current mainstream gradient optimization algorithms. The work in this paper remedy this…

Machine Learning · Statistics 2021-10-08 Aixiang Chen

Strings form a fundamental data type in computer systems. String searching has been extensively studied since the inception of computer science. Increasingly many applications have to deal with imprecise strings or strings with fuzzy…

Databases · Computer Science 2015-09-30 Sharma V. Thankachan , Manish Patil , Rahul Shah , Sudip Biswas

Inference-time computation offers a powerful axis for scaling the performance of language models. However, naively increasing computation in techniques like Best-of-N sampling can lead to performance degradation due to reward hacking.…

Artificial Intelligence · Computer Science 2025-04-09 Audrey Huang , Adam Block , Qinghua Liu , Nan Jiang , Akshay Krishnamurthy , Dylan J. Foster

The problem of biclustering consists of the simultaneous clustering of rows and columns of a matrix such that each of the submatrices induced by a pair of row and column clusters is as uniform as possible. In this paper we approximate the…

Data Structures and Algorithms · Computer Science 2008-08-22 Kai Puolamäki , Sami Hanhijärvi , Gemma C. Garriga

In many statistical linear inverse problems, one needs to recover classes of similar curves from their noisy images under an operator that does not have a bounded inverse. Problems of this kind appear in many areas of application.…

Statistics Theory · Mathematics 2020-03-24 Rasika Rajapakshage , Marianna Pensky

The gamma-index test has been commonly adopted to quantify the degree of agreement between a reference dose distribution and an evaluation dose distribution. Monte Carlo (MC) simulation has been widely used for the radiotherapy dose…

Medical Physics · Physics 2015-06-11 Yan Jiang Graves , Xun Jia , Steve B. Jiang

Algorithms to find optimal alignments among strings, or to find a parsimonious summary of a collection of strings, are well studied in a variety of contexts, addressing a wide range of interesting applications. In this paper, we consider…

Social and Information Networks · Computer Science 2020-11-09 Patty Commins , David Liben-Nowell , Tina Liu , Kiran Tomlinson

We investigate the problem of designing optimal classifiers in the strategic classification setting, where the classification is part of a game in which players can modify their features to attain a favorable classification outcome (while…

Machine Learning · Computer Science 2020-05-19 Mark Braverman , Sumegha Garg

Best-of-N (BoN) sampling is a widely used inference-time alignment method for language models, whereby N candidate responses are sampled from a reference model and the one with the highest predicted reward according to a learned reward…

Machine Learning · Computer Science 2026-03-09 Ved Sriraman , Adam Block

In classification problems, sampling bias between training data and testing data is critical to the ranking performance of classification scores. Such bias can be both unintentionally introduced by data collection and intentionally…

Methodology · Statistics 2017-11-02 Chandler Zuo

The aim of this paper is to justify in dimensions two and three the ansatz of Caracciolo et al. stating that the displacement in the optimal matching problem is essentially given by the solution to the linearized equation i.e. the Poisson…

Probability · Mathematics 2021-05-10 Michael Goldman , Martin Huesmann

In a \emph{weighted sequence}, for every position of the sequence and every letter of the alphabet a probability of occurrence of this letter at this position is specified. Weighted sequences are commonly used to represent imprecise or…

Data Structures and Algorithms · Computer Science 2017-08-28 Carl Barton , Tomasz Kociumaka , Chang Liu , Solon P. Pissis , Jakub Radoszewski

We consider the problem of estimating expectations with respect to a target distribution with an unknown normalizing constant, and where even the unnormalized target needs to be approximated at finite resolution. Under such an assumption,…

Numerical Analysis · Mathematics 2023-06-29 Xinzhu Liang , Shangda Yang , Simon L. Cotter , Kody J. H. Law

Handwritten text recognition aims to convert visual input into machine-readable text, and it remains challenging due to the evolving and context-dependent nature of handwriting. Character sets change over time, and character frequency…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Panagiotis Kaliosis , John Pavlopoulos

(Partial) ranking loss is a commonly used evaluation measure for multi-label classification, which is usually optimized with convex surrogates for computational efficiency. Prior theoretical work on multi-label ranking mainly focuses on…

Machine Learning · Computer Science 2021-05-12 Guoqiang Wu , Chongxuan Li , Kun Xu , Jun Zhu

Numbers and numerical vectors account for a large portion of data. However, recently the amount of string data generated has increased dramatically. Consequently, classifying string data is a common problem in many fields. The most widely…

Machine Learning · Statistics 2016-02-24 Hitoshi Koyano , Morihiro Hayashida , Tatsuya Akutsu