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Amino acid sequence portrays most intrinsic form of a protein and expresses primary structure of protein. The order of amino acids in a sequence enables a protein to acquire a particular stable conformation that is responsible for the…

Machine Learning · Computer Science 2022-08-29 Ashish Ranjan , Md Shah Fahad , David Fernandez-Baca , Akshay Deepak , Sudhakar Tripathi

Machine learning (ML) approaches have been used to develop highly accurate and efficient applications in many fields including bio-medical science. However, even with advanced ML techniques, cancer classification using gene expression data…

Genomics · Quantitative Biology 2023-05-10 Mahmood Khalsan , Mu Mu , Eman Salih Al-Shamery , Lee Machado , Suraj Ajit , Michael Opoku Agyeman

Signaling proteins are an important topic in drug development due to the increased importance of finding fast, accurate and cheap methods to evaluate new molecular targets involved in specific diseases. The complexity of the protein…

Quantitative Methods · Quantitative Biology 2019-04-11 Carlos Fernandez-Lozano , Ruben F. Cuinas , Jose A. Seoane , Enrique Fernandez-Blanco , Julian Dorado , Cristian R. Munteanu

Proteins perform much of the work in living organisms, and consequently the development of efficient computational methods for protein representation is essential for advancing large-scale biological research. Most current approaches…

Quantitative Methods · Quantitative Biology 2023-06-09 Francesco Ceccarelli , Lorenzo Giusti , Sean B. Holden , Pietro Liò

Advanced automated AI techniques allow us to classify protein sequences and discern their biological families and functions. Conventional approaches for classifying these protein families often focus on extracting N-Gram features from the…

Quantitative Methods · Quantitative Biology 2024-10-24 Bahar Ali , Anwar Shah , Malik Niaz , Musadaq Mansoord , Sami Ullah , Muhammad Adnan

The goal of protein representation learning is to extract knowledge from protein databases that can be applied to various protein-related downstream tasks. Although protein sequence, structure, and function are the three key modalities for…

Biomolecules · Quantitative Biology 2024-05-14 Eunji Ko , Seul Lee , Minseon Kim , Dongki Kim

Sequence set is a widely-used type of data source in a large variety of fields. A typical example is protein structure prediction, which takes an multiple sequence alignment (MSA) as input and aims to infer structural information from it.…

Biomolecules · Quantitative Biology 2019-06-27 Fusong Ju , Jianwei Zhu , Guozheng Wei , Qi Zhang , Shiwei Sun , Dongbo Bu

Data discretization, also known as binning, is a frequently used technique in computer science, statistics, and their applications to biological data analysis. We present a new method for the discretization of real-valued data into a finite…

Other Quantitative Biology · Quantitative Biology 2007-05-23 Elena S. Dimitrova , John J. McGee , Reinhard C. Laubenbacher

Data Mining is the process of extracting useful patterns from the huge amount of database and many data mining techniques are used for mining these patterns. Recently, one of the remarkable facts in higher educational institute is the rapid…

Artificial Intelligence · Computer Science 2014-05-16 Priyanka Saini

The Fuzzy Gene Filter (FGF) is an optimised Fuzzy Inference System designed to rank genes in order of differential expression, based on expression data generated in a microarray experiment. This paper examines the effectiveness of the FGF…

Machine Learning · Computer Science 2011-08-24 Meir Perez , Tshilidzi Marwala

MOTIVATION: Proteins fold into complex structures that are crucial for their biological functions. Experimental determination of protein structures is costly and therefore limited to a small fraction of all known proteins. Hence, different…

Biomolecules · Quantitative Biology 2018-04-18 David Menéndez Hurtado , Karolis Uziela , Arne Elofsson

The generation of protein crystals is necessary for the study of protein molecular function and structure. This is done empirically by processing large numbers of crystallization trials and inspecting them regularly in search of those with…

Computer Vision and Pattern Recognition · Computer Science 2018-05-15 Soheil Ghafurian , Peter Orth , Corey Strickland , Hua Su , Sangita Patel , Steven Soisson , Belma Dogdas

Sequence classification is an important data mining task in many real world applications. Over the past few decades, many sequence classification methods have been proposed from different aspects. In particular, the pattern-based method is…

Machine Learning · Computer Science 2020-12-15 Zengyou He , Guangyao Xu , Chaohua Sheng , Bo Xu , Quan Zou

This research aims to examine the usefulness of integrating various feature selection methods with regression algorithms for sleep quality prediction. A publicly accessible sleep quality dataset is used to analyze the effect of different…

Machine Learning · Computer Science 2023-03-07 Sai Rohith Tanuku , Venkat Tummala

Neural compression is the application of neural networks and other machine learning methods to data compression. Recent advances in statistical machine learning have opened up new possibilities for data compression, allowing compression…

Machine Learning · Computer Science 2023-08-22 Yibo Yang , Stephan Mandt , Lucas Theis

The analysis of sequences (e.g., protein, DNA, and SMILES string) is essential for disease diagnosis, biomaterial engineering, genetic engineering, and drug discovery domains. Conventional analytical methods focus on transforming sequences…

Quantitative Methods · Quantitative Biology 2025-03-20 Taslim Murad , Sarwan Ali , Murray Patterson

Agricultural research has been profited by technical advances such as automation, data mining. Today, data mining is used in a vast areas and many off-the-shelf data mining system products and domain specific data mining application soft…

Artificial Intelligence · Computer Science 2012-06-08 Jay Gholap , Anurag Ingole , Jayesh Gohil , Shailesh Gargade , Vahida Attar

With the advent of high-throughput wet lab technologies the amount of protein interaction data available publicly has increased substantially, in turn spurring a plethora of computational methods for in silico knowledge discovery from this…

Molecular Networks · Quantitative Biology 2015-05-06 Sriganesh Srihari , Hon Wai Leong

An ensemble based approach for dealing with missing data, without predicting or imputing the missing values is proposed. This technique is suitable for online operations of neural networks and as a result, is used for online condition…

Artificial Intelligence · Computer Science 2007-05-23 F. V. Nelwamondo , T. Marwala

Classification, which involves finding rules that partition a given data set into disjoint groups, is one class of data mining problems. Approaches proposed so far for mining classification rules for large databases are mainly decision tree…

Machine Learning · Computer Science 2017-01-09 Hongjun Lu , Rudy Setiono , Huan Liu