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Compared to imaging in the visible and near-infrared regions below 900 nm, imaging in the second near-infrared window (NIR-II, 1000-1700 nm) is a promising method for deep-tissue high-resolution optical imaging in vivo mainly due to the…
Fluorescent imaging in the second near infrared window (NIR II, 1-1.4 {\mu}m) holds much promise due to minimal autofluorescence and tissue scattering. Here, using well functionalized biocompatible single-walled carbon nanotubes (SWNTs) as…
The second near-infrared window (NIR-II, 900-1,880 nm) has been pivotal in advancing in vivo fluorescence imaging due to its superior penetration depth and contrast. Yet, its clinical utility remains limited by insufficient imaging…
In vivo fluorescence imaging in the second near-infrared window (1.0-1.7 microns) can afford deep tissue penetration and high spatial resolution, owing to the reduced scattering of long-wavelength photons. Here, we synthesize a series of…
NIR-II fluorescence imaging provides superior tissue penetration and clarity, yet its clinical use in surgical navigation is hindered by a critical workflow issue. Surgeons must divert their attention between the operative field and…
Conventional biomedical imaging modalities, including endoscopy, X-rays, and magnetic resonance, are invasive and cannot provide sufficient spatial and temporal resolutions for regular imaging of gastrointestinal (GI) tract to guide…
Circulatory system abnormalities might be an indicator of diseases or tissue damage. Early detection of vascular abnormalities might have an important role during treatment and also raise the patient's awarenes. Current detection methods…
Hyperspectral imaging captures both spectral and spatial information from a sample. The near infrared (NIR, > 800 nm) is advantageous for biomedical imaging as it falls into the tissue transparency window but also contains vibrational…
The near infrared (NIR) region of the electromagnetic spectrum contains valuable information about vibrational overtone and combination modes. Additionally, fluorophores that emit in the NIR are desired because this spectral range falls…
Non-degenerate two-photon absorption (NTA) offers an attractive route for wide-field mid-infrared (MIR) imaging by mapping long wavelength information into the spectral detection windows of mature near-infrared detector technologies.…
Low quantum yields of near infrared (NIR) fluorophores have limited their capabilities as imaging probes in a transparent, low background imaging window. Here for the first time we reported near-infrared fluorescence enhance (NIR-FE) cell…
Near-infrared (NIR) hyperspectral imaging is widely used to reveal morphological and chemical information. However, conventional spectral imagers usually rely on costly focal plane arrays and suffer from data redundancy and inefficiencies…
To date, brain imaging has largely relied on X-ray computed tomography and magnetic resonance angiography with limited spatial resolution and long scanning times. Fluorescence-based brain imaging in the visible and traditional near-infrared…
Advancement in mid-infrared (MIR) technology has led to promising biomedical applications of MIR spectroscopy, such as liquid biopsy or breath diagnosis. On the contrary, MIR microscopy has been rarely used for live biological samples in an…
Infrared (IR) dyes, especially those within the near-infrared (NIR) spectrum, offer substantial advantages for in vivo imaging, owing to their deep tissue penetration and minimal background autofluorescence. Nanoparticles incorporating…
Tissue oxygenation and perfusion can be an indicator for organ viability during minimally invasive surgery, for example allowing real-time assessment of tissue perfusion and oxygen saturation. Multispectral imaging is an optical modality…
Conventional near-infrared spectroscopy (NIRS) instruments typically employ 2-3 wavelengths for monitoring tissue haemodynamics. However, the use of broadband illumination (hundreds of wavelengths) unlocks also the targeting of tissue…
Scattering-type scanning near-field optical microscopy (s-SNOM), and its derivate, Fourier transform infrared nanospectroscopy (nano-FTIR) are emerging techniques for infrared (IR) nanoimaging and spectroscopy with applications in diverse…
Label-free vibrational microscopy provides chemically specific access to cellular structure, yet quantitative volumetric chemical dynamics in living cells remain largely inaccessible, particularly on subsecond timescales relevant to…
Mid-infrared photo-induced force microscopy (IR-PiFM/PiF-IR) enables high-resolution chemical imaging of surfaces with lateral resolution less than 5 nm. Here are some answers to questions about the physical background, practical handling…