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We introduce a multi-species lattice gas model for motor protein driven collective cargo transport on cellular filaments. We use this model to describe and analyze the collective motion of interacting vesicle cargoes being carried by…

Statistical Mechanics · Physics 2010-09-10 Sudipto Muhuri , Ignacio Pagonabarraga

We use stochastic computer simulations to study the transport of a spherical cargo particle along a microtubule-like track on a planar substrate by several kinesin-like processive motors. Our newly developed adhesive motor dynamics…

Subcellular Processes · Quantitative Biology 2010-02-24 Christian B. Korn , Stefan Klumpp , Reinhard Lipowsky , Ulrich S. Schwarz

We study dynamics of a classical particle in a one-dimensional potential, which is composed of two periodic components, that are time-independent, have equal amplitudes and periodicities. One of them is externally driven by a random force…

Statistical Mechanics · Physics 2007-05-23 G. Oshanin , J. Klafter , M. Urbakh

Intracellular transport of organelles is fundamental to cell function and health. The mounting evidence suggests that this transport is in fact anomalous. However, the reasons for the anomaly is still under debate. We examined experimental…

Subcellular Processes · Quantitative Biology 2018-12-10 Nickolay Korabel , Thomas A. Waigh , Sergei Fedotov , Viki J. Allan

We show that particle transport in a uniform, quantum multi-baker map, is generically ballistic in the long time limit, for any fixed value of Planck's constant. However, for fixed times, the semi-classical limit leads to diffusion. Random…

Quantum Physics · Physics 2009-11-07 Daniel K. Wojcik , J. R. Dorfman

Intracellular transport is mediated by molecular motors that pull cargos along cytoskeletal filaments. Many cargos move bidirectionally and are transported by two teams of motors which move into opposite directions along the filament. We…

Biological Physics · Physics 2008-12-16 Melanie J. I. Muller , Stefan Klumpp , Reinhard Lipowsky

Electrophoretic (EP) mobility reversal is commonly observed for strongly charged macromolecules in multivalent salt solutions. This curious effect takes place, e.g., when a charged polymer, such as DNA, adsorbs excess counterions so that…

Soft Condensed Matter · Physics 2023-03-28 Xiang Yang , Sahin Buyukdagli , Alberto Scacchi , Maria Sammalkorpi , Tapio Ala-Nissila

We discuss a theoretical model for bidirectional cargo transport in biological cells, which is driven by teams of molecular motors and subject to thermal fluctuations. The model describes explicitly the directed motion of the molecular…

Biological Physics · Physics 2017-09-20 Sarah Klein , Cécile Appert-Rolland , Ludger Santen

The cytoskeleton -- a composite network of biopolymers, molecular motors, and associated binding proteins -- is a paradigmatic example of active matter. Particle transport through the cytoskeleton can range from anomalous and heterogeneous…

We quantify superdiffusive transience for a two-dimensional random walk in which the vertical coordinate is a martingale and the horizontal coordinate has a positive drift that is a polynomial function of the individual coordinates and of…

Probability · Mathematics 2024-07-03 Conrado da Costa , Mikhail Menshikov , Vadim Shcherbakov , Andrew Wade

We study an active random walker model in which a particle's motion is determined by a self-generated field. The field encodes information about the particle's path history. This leads to either self-attractive or self-repelling behavior.…

Statistical Mechanics · Physics 2009-11-11 R. Grima

Cells and organisms follow aligned structures in their environment, a process that can generate persistent migration paths. Kinetic transport equations are a popular modelling tool for describing biological movements at the mesoscopic…

Cell Behavior · Quantitative Biology 2021-01-13 Nadia Loy , Thomas Hillen , Kevin John Painter

In this work, we consider a multi-wheeled payload transport system. Each of the wheels can be selectively actuated. When they are not actuated, wheels are free moving and do not consume battery power. The payload transport system is modeled…

Robotics · Computer Science 2019-09-11 Rahul Tallamraju , Pulkit Verma , Venkatesh Sripada , Shrey Agrawal , Kamalakar Karlapalem

In this paper, we study the properties of lackadaisical quantum walks on a line. This model is first proposed in~\cite{wong2015grover} as a quantum analogue of lazy random walks where each vertex is attached $\tau$ self-loops. We derive an…

Quantum Physics · Physics 2020-01-10 Kun Wang , Nan Wu , Ping Xu , Fangmin Song

L\'evy walks are continuous time random walks with spatio-temporal coupling of jump lengths and waiting times, often used to model superdiffusive spreading processes such as animals searching for food, tracer motion in weakly chaotic…

Statistical Mechanics · Physics 2019-03-27 Bartłomiej Dybiec , Karol Capała , Aleksei Chechkin , Ralf Metzler

The transport by molecular motors along cytoskeletal filaments is studied theoretically in the presence of static defects. The movements of single motors are described as biased random walks along the filament as well as binding to and…

Biological Physics · Physics 2009-05-08 Yan Chai , Reinhard Lipowsky , Stefan Klumpp

Molecular motors are specialized proteins which perform active, directed transport of cellular cargoes on cytoskeletal filaments. In many cases, cargo motion powered by motor proteins is found to be bidirectional, and may be viewed as a…

Subcellular Processes · Quantitative Biology 2015-06-16 Deepak Bhat , Manoj Gopalakrishnan

The collective behavior of molecular motor proteins have been investigated in the literature using models to describe the long-time dynamics of a unidimensional continuum motor distribution. Here, we consider the phenomena related to the…

Subcellular Processes · Quantitative Biology 2008-03-20 Daniel Gomes Lichtenthaler , Carla Goldman

The transport of cargo particles which are pulled by several molecular motors in a cooperative manner is studied theoretically. The transport properties depend primarily on the maximal number, $N$, of motor molecules that may pull…

Subcellular Processes · Quantitative Biology 2007-05-23 Stefan Klumpp , Reinhard Lipowsky

Continuous time random walks combining diffusive and ballistic regimes are introduced to describe a class of L\'evy walks on lattices. By including exponentially-distributed waiting times separating the successive jump events of a walker,…

Statistical Mechanics · Physics 2014-12-02 Giampaolo Cristadoro , Thomas Gilbert , Marco Lenci , David P. Sanders