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Biologists and physicists have a rich tradition of modeling living systems with simple models composed of a few interacting components. Despite the remarkable success of this approach, it remains unclear how to use such finely tuned models…

Biological Physics · Physics 2025-09-05 Ilya Nemenman , Pankaj Mehta

Self-organization offers a promising approach for designing adaptive systems. Given the inherent complexity of most cyber-physical systems, adaptivity is desired, as predictability is limited. Here I summarize different concepts and…

Multiagent Systems · Computer Science 2026-02-04 Carlos Gershenson

Complex dynamical systems driven by the unravelling of information can be modelled effectively by treating the underlying flow of information as the model input. Complicated dynamical behaviour of the system is then derived as an output.…

Physics and Society · Physics 2019-11-05 Dorje C Brody

Human activity has an enormous impact on Earth, changing organisms, environments and landscapes, leading to the decline of original ecosystems and irreversible changes that create new combinations of living beings and materials. As a…

Populations and Evolution · Quantitative Biology 2026-02-10 Clara de Goes Monteiro de Carvalho Guimaraes , Pablo Jose Francisco Pena Rodrigues

Why are living systems complex? Why does the biosphere contain living beings with complexity features beyond those of the simplest replicators? What kind of evolutionary pressures result in more complex life forms? These are key questions…

Populations and Evolution · Quantitative Biology 2023-11-13 Seoane LF , Solé R

Computational intelligence is broadly defined as biologically-inspired computing. Usually, inspiration is drawn from neural systems. This article shows how to analyze neural systems using information theory to obtain constraints that help…

Neurons and Cognition · Quantitative Biology 2018-05-11 Michael Wibral , Joseph T. Lizier , Viola Priesemann

Social tipping points are promising levers to achieve net-zero greenhouse gas emission targets. They describe how social, political, economic or technological systems can move rapidly into a new state if cascading positive feedback…

Composition is a powerful principle for systems biology, focused on the interfaces, interconnections, and orchestration of distributed processes to enable integrative multiscale simulations. Whereas traditional models focus on the structure…

Other Quantitative Biology · Quantitative Biology 2024-11-25 Eran Agmon

A key challenge in modern computing is to develop systems that address complex, dynamic problems in a scalable and efficient way, because the increasing complexity of software makes designing and maintaining efficient and flexible systems…

Other Computer Science · Computer Science 2015-05-19 Gerard Briscoe , Paolo Dini

Democratic governments comprise a subset of a population whose goal is to produce coherent decisions, solving societal challenges while respecting the will of the people. New governance frameworks represent this as a social network rather…

The human nervous system utilizes synaptic plasticity to solve optimization problems. Previous studies have tried to add the plasticity factor to the training process of artificial neural networks, but most of those models require complex…

Neural and Evolutionary Computing · Computer Science 2022-04-13 Amir Valizadeh

Like all natural systems, great societies and their cultures emerge by a growth process from their environments, developing, organized, and behaving as wholes with their internal designs linked with their external worlds. So the general…

Physics and Society · Physics 2022-08-16 Jessie Henshaw

Microbiome-based stratification of healthy individuals into compositional categories, referred to as "community types", holds promise for drastically improving personalized medicine. Despite this potential, the existence of community types…

Quantitative Methods · Quantitative Biology 2016-04-27 Travis E. Gibson , Amir Bashan , Hong-Tai Cao , Scott T. Weiss , Yang-Yu Liu

Empirical evidence suggesting that living systems might operate in the vicinity of critical points, at the borderline between order and disorder, has proliferated in recent years, with examples ranging from spontaneous brain activity to…

Statistical Mechanics · Physics 2014-07-25 Jorge Hidalgo , Jacopo Grilli , Samir Suweis , Miguel A. Munoz , Jayanth R. Banavar , Amos Maritan

Reaction systems are discrete dynamical systems inspired by bio-chemical processes, whose dynamical behaviour is expressed by set-theoretic operations on finite sets. Reaction systems thus provide a description of bio-chemical phenomena…

Formal Languages and Automata Theory · Computer Science 2020-08-05 Alberto Dennunzio , Enrico Formenti , Luca Manzoni , Antonio E. Porreca

Instances of critical-like characteristics in living systems at each organizational level as well as the spontaneous emergence of computation (Langton), indicate the relevance of self-organized criticality (SOC). But extrapolating complex…

Other Quantitative Biology · Quantitative Biology 2012-08-23 Gargi Mitra-Delmotte , A. N. Mitra

What makes living systems flexible so that they can react quickly and adapt easily to changing environments? This question has not only engaged biologists for decades but is also of great interest to computer scientists and engineers who…

Systems and Control · Electrical Eng. & Systems 2022-07-12 Sebastian Mayer , Leo Francoso Dal Piccol Sotto , Jochen Garcke

Unlike many physical nonequilibrium systems, in biological systems, the coupling to external energy sources is not a fixed parameter but adaptively controlled by the system itself. We do not have theoretical frameworks that allow for such…

Populations and Evolution · Quantitative Biology 2025-06-30 Ankit Dhanuka , Avi I. Flamholz , Arvind Murugan , Akshit Goyal

Living systems exhibit a range of fundamental characteristics: they are active, self-referential, self-modifying systems. This paper explores how these characteristics create challenges for conventional scientific approaches and why they…

Emerging Technologies · Computer Science 2025-08-18 Samson Abramsky , Wolfgang Banzhaf , Leo S. D. Caves , Michael Levin , Penousal Machado , Charles Ofria , Susan Stepney , Roger White

The emergence of complex structures in the systems governed by a simple set of rules is among the most fascinating aspects of Nature. The particularly powerful and versatile model suitable for investigating this phenomenon is provided by…

Adaptation and Self-Organizing Systems · Physics 2023-10-11 Jarosław Adam Miszczak