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Within the intensive care unit (ICU), a wealth of patient data, including clinical measurements and clinical notes, is readily available. This data is a valuable resource for comprehending patient health and informing medical decisions, but…

Machine Learning · Computer Science 2023-12-13 Ryan King , Tianbao Yang , Bobak Mortazavi

Background: Medical decision-making impacts both individual and public health. Clinical scores are commonly used among a wide variety of decision-making models for determining the degree of disease deterioration at the bedside. AutoScore…

When constructing models to summarize clinical data to be used for simulations, it is good practice to evaluate the models for their capacity to reproduce the data. This can be done by means of Visual Predictive Checks (VPC), which consist…

Applications · Statistics 2021-05-06 Christian Bartels , Thomas Dumortier

Rigorous external validation is crucial for assessing the generalizability of prediction models, particularly by evaluating their discrimination (AUROC) on new data. This often involves comparing a new model's AUROC to that of an…

Methodology · Statistics 2025-01-07 François Grolleau , Robert Tibshirani , Jonathan H. Chen

Various assumptions on a right-censoring mechanism to ensure consistency of the Kaplan--Meier and Aalen--Johansen estimators in a competing risks setting are studied. Specifically, eight different assumptions are seen to fall in two…

Statistics Theory · Mathematics 2024-12-11 Morten Overgaard , Stefan Nygaard Hansen

In this paper the regression discontinuity design is adapted to the survival analysis setting with right-censored data, studied in an intensity based counting process framework. In particular, a local polynomial regression version of the…

Methodology · Statistics 2022-10-07 Emil Aas Stoltenberg

The selective classifier (SC) has been proposed for rank based uncertainty thresholding, which could have applications in safety critical areas such as medical diagnostics, autonomous driving, and the justice system. The Area Under the…

Machine Learning · Statistics 2025-09-04 Han Zhou , Jordy Van Landeghem , Teodora Popordanoska , Matthew B. Blaschko

Cohort studies of the onset of a disease often encounter left-truncation on the event time of interest in addition to right-censoring due to variable enrollment times of study participants. Analysis of such event time data can be biased if…

Methodology · Statistics 2025-04-11 Spencer Matthews , Bin Nan

Given that machine learning algorithms are increasingly being deployed to aid in high stakes decision-making, uncertainty quantification methods that wrap around these black box models such as conformal prediction have received much…

Machine Learning · Statistics 2026-02-09 Kayla E. Scharfstein , Arun Kumar Kuchibhotla

Estimating counterfactual outcomes over time has the potential to unlock personalized healthcare by assisting decision-makers to answer ''what-iF'' questions. Existing causal inference approaches typically consider regular, discrete-time…

Machine Learning · Computer Science 2022-06-17 Nabeel Seedat , Fergus Imrie , Alexis Bellot , Zhaozhi Qian , Mihaela van der Schaar

The use of machine learning models in consequential decision making often exacerbates societal inequity, in particular yielding disparate impact on members of marginalized groups defined by race and gender. The area under the ROC curve…

Machine Learning · Computer Science 2022-11-30 Zhenhuan Yang , Yan Lok Ko , Kush R. Varshney , Yiming Ying

Accurately predicting the time of occurrence of an event of interest is a critical problem in longitudinal data analysis. One of the main challenges in this context is the presence of instances whose event outcomes become unobservable after…

Machine Learning · Computer Science 2017-12-26 Ping Wang , Yan Li , Chandan K. Reddy

We propose a restricted win probability estimand for comparing treatments in a randomized trial with a time-to-event outcome. We also propose Bayesian estimators for this summary measure as well as the unrestricted win probability. Bayesian…

Methodology · Statistics 2024-11-06 Michelle Leeberg , Xianghua Luo , Thomas A. Murray

The performance of many machine learning techniques depends on the choice of an appropriate similarity or distance measure on the input space. Similarity learning (or metric learning) aims at building such a measure from training data so…

Machine Learning · Statistics 2019-01-25 Robin Vogel , Aurélien Bellet , Stéphan Clémençon

In recent years, there has been growing interest in causal machine learning estimators for quantifying subject-specific effects of a binary treatment on time-to-event outcomes. Estimation approaches have been proposed which attenuate the…

Methodology · Statistics 2026-03-30 Matthew Pryce , Karla Diaz-Ordaz , Ruth H. Keogh , Stijn Vansteelandt

It is often of interest to study the association between covariates and the cumulative incidence of a right-censored time-to-event outcome. When time-varying covariates are measured on a fixed discrete time scale, it is desirable to account…

Methodology · Statistics 2026-04-28 Hongxiang Qiu , Marco Carone , Alex Luedtke , Peter B. Gilbert

Recently, ACM FAccT published an article by Kwegyir-Aggrey and colleagues (2023), critiquing the use of AUC ROC in predictive analytics in several domains. In this article, we offer a critique of that article. Specifically, we highlight…

Machine Learning · Computer Science 2024-04-11 Ryan S. Baker , Nigel Bosch , Stephen Hutt , Andres F. Zambrano , Alex J. Bowers

Graph classification in medical imaging and drug discovery requires accuracy and robust uncertainty quantification. To address this need, we introduce Conditional Prediction ROC (CP-ROC) bands, offering uncertainty quantification for ROC…

Machine Learning · Computer Science 2024-10-22 Yujia Wu , Bo Yang , Elynn Chen , Yuzhou Chen , Zheshi Zheng

Survival analysis is a valuable tool for estimating the time until specific events, such as death or cancer recurrence, based on baseline observations. This is particularly useful in healthcare to prognostically predict clinically important…

Machine Learning · Computer Science 2024-01-11 Ahmed H. Shahin , An Zhao , Alexander C. Whitehead , Daniel C. Alexander , Joseph Jacob , David Barber

Receiver operating characteristic (ROC) analysis is a tool to evaluate the capacity of a numeric measure to distinguish between groups, often employed in the evaluation of diagnostic tests. Overall classification ability is sometimes…