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Second harmonic optical coherence tomography, which uses coherence gating of second-order nonlinear optical response of biological tissues for imaging, is described and demonstrated. Femtosecond laser pulses were used to excite second…

Optics · Physics 2009-11-10 Yi Jiang , Ivan Tomov , Yimin Wang , Zhongping Chen

Automatic motion compensation and adjustment of an intraoperative imaging modality's field of view is a common problem during interventions. Optical coherence tomography (OCT) is an imaging modality which is used in interventions due to its…

Computer Vision and Pattern Recognition · Computer Science 2019-03-12 Nils Gessert , Martin Gromniak , Matthias Schlüter , Alexander Schlaefer

We exercise rapid and fine control over the phase of light by transferring digitally gen- erated phase jumps from radio frequency (rf) electrical signals onto light by means of acousto-optic interaction. By tailoring the statistics of phase…

We present an imaging technique particularly suited to the detection of a target embedded in a strongly scattering medium. Classical imaging techniques based on the Born approximation fail in this kind of configuration because of multiply…

Classical Physics · Physics 2009-08-21 Alexandre Aubry , Arnaud Derode

One of the greatest needs in modern ophthalmology is access to the eye choroid in vivo. Without it, it is difficult to introduce new therapies and to understand most of the pathological changes in the eye, because of the total blood flow in…

In this paper, we propose a framework that incorporates experts diagnostics and insights into the analysis of Optical Coherence Tomography (OCT) using multi-modal learning. To demonstrate the effectiveness of this approach, we create a…

Image and Video Processing · Electrical Eng. & Systems 2022-03-22 Y. Logan , K. Kokilepersaud , G. Kwon , G. AlRegib , C. Wykoff , H. Yu

Polarization-sensitive quantum optical coherence tomography (PS-QOCT) makes use of a Type-II twin-photon light source for carrying out optical sectioning with polarization sensitivity. A BBO nonlinear optical crystal pumped by a Ti:sapphire…

Quantum Physics · Physics 2019-10-18 Mark C. Booth , Bahaa E. A. Saleh , Malvin Carl Teich

Quantum Optical Coherence Tomography (Q-OCT) is a non-classical equivalent of Optical Coherence Tomography and is able to provide a twofold axial resolution increase and immunity to resolution-degrading dispersion. The main drawback of…

Signal Processing · Electrical Eng. & Systems 2021-04-22 Sylwia M. Kolenderska , Maciej Szkulmowski

With the introduction of spectral-domain optical coherence tomography (OCT), much larger image datasets are routinely acquired compared to what was possible using the previous generation of time-domain OCT. Thus, the need for 3-D…

Computer Vision and Pattern Recognition · Computer Science 2012-05-03 Yankui Sun , Tian Zhang

We propose a tomographic method to reconstruct the optical properties of a highly-scattering medium from incoherent acousto-optic measurements. The method is based on the solution to an inverse problem for the diffusion equation and makes…

Optics · Physics 2015-05-14 Guillaume Bal , John C Schotland

Quantum optical coherence tomography (QOCT) offers a simple way to cancel dispersion broadening in a sample while also providing twice the resolution compared to classical OCT. However, to achieve these advantages, a bright and broadband…

Quantum Physics · Physics 2025-12-15 Anna Romanova , Vadim Rodimin , Konstantin Katamadze

Optical coherence Doppler tomography (ODT) is an emerging blood flow imaging technique. The fundamental unit of ODT is the 1D depth-resolved trace named raw A-scans (or A-line). A 2D ODT image (B-scan) is formed by reconstructing a…

Computer Vision and Pattern Recognition · Computer Science 2025-08-01 Zhenghong Li , Jiaxiang Ren , Wensheng Cheng , Yanzuo Liu , Congwu Du , Yingtian Pan , Haibin Ling

High-resolution Optical Coherence Tomography (OCT) images are crucial for ophthalmology studies but are limited by their relatively narrow field of view (FoV). Image mosaicking is a technique for aligning multiple overlapping images to…

Image and Video Processing · Electrical Eng. & Systems 2024-07-29 Jiacheng Wang , Hao Li , Dewei Hu , Yuankai K. Tao , Ipek Oguz

Fluorescent imaging plays a critical role in a myriad of scientific endeavors, particularly in the biological sciences. Three-dimensional imaging of fluorescent intensity often requires serial data acquisition, that is voxel-by-voxel…

Optics · Physics 2015-10-27 Jeffrey J. Field , David G. Winters , Randy A. Bartels

Currently, diagnosis of skin diseases is based primarily on visual pattern recognition skills and expertise of the physician observing the lesion. Even though dermatologists are trained to recognize patterns of morphology, it is still a…

A resolution enhancement technique for optical coherence tomography (OCT), based on Generative Adversarial Networks (GANs), was developed and investigated. GANs have been previously used for resolution enhancement of photography and optical…

Image and Video Processing · Electrical Eng. & Systems 2021-01-19 Kaicheng Liang , Xinyu Liu , Si Chen , Jun Xie , Wei Qing Lee , Linbo Liu , Hwee Kuan Lee

Holographic coherent X-ray imaging enables nanoscale imaging of biological cells and tissues, rendering both phase and absorption contrast, i.e. real and imaginary parts of the refractive index. Unlike the standard model, which assumes a…

Analysis of PDEs · Mathematics 2026-05-29 Thorsten Hohage , Milad Karimi , Björn Müller

We report an optimized implementation of spectral-domain quantum optical coherence tomography (SD-QOCT) capable of acquiring axial scans (A-scans) of multilayer samples without in the absence of mechanical scanning, at an unprecedented…

Accelerating imaging speed in optical microscopy is often realized at the expense of image contrast, image resolution, and detection sensitivity- a common predicament for advancing high-speed and high-throughput cellular imaging. We here…

Optical coherence tomography (OCT) is a prevalent imaging technique for retina. However, it is affected by multiplicative speckle noise that can degrade the visibility of essential anatomical structures, including blood vessels and tissue…

Image and Video Processing · Electrical Eng. & Systems 2021-07-12 Dewei Hu , Joseph D. Malone , Yigit Atay , Yuankai K. Tao , Ipek Oguz