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Conventional 2D fluorescence imaging in glioma surgery cannot separate intrinsic fluorophore strength from attenuation with depth, creating depth-intensity ambiguity that can compromise assessment of residual tumour and fluorescence based…

Medical Physics · Physics 2026-04-07 Yucheng Bian , Sebastien Ourselin , Yijing Xie

We introduce a new image cytometer design for detection of very small particulate and demonstrate its capability in water analysis. The device is a compact microscope composed of off the shelf components, such as a light emitting diode…

Optics · Physics 2016-02-17 Juan Miguel Pérez , Marc Jofre , Pedro Martínez , Valerio Pruneri

The electrical response of ferroelectric domain walls is often influenced by their geometry underneath the sample surface. Tomographic imaging in these material systems has therefore become increasingly important for its ability to…

In this study, a radiomics approach was extended to optical fluorescence molecular imaging data for tissue classification, termed 'optomics'. Fluorescence molecular imaging is emerging for precise surgical guidance during head and neck…

Accurate segmentation of organs and lesions in medical images is essential for clinical applications including diagnosis, prognosis, and treatment planning. While Vision Transformers (ViTs) have shown impressive segmentation performance,…

Image and Video Processing · Electrical Eng. & Systems 2026-05-13 Jin Yang , Xiaobing Yu , Peijie Qiu

The detection of atmospheric fluorescence light from extensive air showers has become a powerful tool for accurate measurements of the energy and mass of ultra-high energy cosmic ray particles. Employing large area imaging telescopes with…

Instrumentation and Methods for Astrophysics · Physics 2009-07-22 Daniel Kruppke-Hansen , Karl-Heinz Kampert

A fast and robust algorithm for fluorescence diffuse optical tomography is proposed. We identify the location of a fluorescence target by assuming a cuboid. The proposed numerical method is verified by a numerical experiment and an in vivo…

Image and Video Processing · Electrical Eng. & Systems 2020-02-19 Chunlong Sun , Yu Jiang , Jijun Liu , Manabu Machida , Gen Nakamura , Goro Nishimura

Dielectric metasurfaces, extremely thin nanostructured dielectric surfaces, hold promise to replace conventional refractive optics, such as lenses, due to their high performance and compactness. However, designing large field-of-view (FOV)…

High precision astrometry aims at source position determination to a very small fraction of the diffraction image size, in high SNR regime. One of the key limitations to such goal is the optical response variation of the telescope over a…

Instrumentation and Methods for Astrophysics · Physics 2021-04-08 Alberto Riva , Mario Gai , Alberto Vecchiato , Deborah Busonero , Mario G. Lattanzi , Federico Landini , Zhaoxiang Qi , Zhenghong Tang

Interaction-free measurement (IFM) has been proposed as a means of high-resolution, low-damage imaging of radiation-sensitive samples, such as biomolecules and proteins. The basic setup for IFM is a Mach-Zehnder interferometer, and recent…

Instrumentation and Detectors · Physics 2019-06-12 Akshay Agarwal , Karl K. Berggren , Vivek Goyal

Nanosecond temporal resolution enables new methods for wide-field imaging like time-of-flight, gated detection, and fluorescence lifetime. The optical efficiency of existing approaches, however, presents challenges for low-light…

Fourier Ptychographic Microscopy (FPM) is a computational technique that achieves a large space-bandwidth product imaging. It addresses the challenge of balancing a large field of view and high resolution by fusing information from multiple…

Optics · Physics 2023-04-21 Ruiqing Sun , Delong Yang , Yao Hu , Qun Hao , Xin Li , Shaohui Zhang

Imaging the bio-impedance distribution of the brain can provide initial diagnosis of acute stroke. This paper presents a compact and non-radiative tomographic modality, i.e. multi-frequency Electromagnetic Tomography (mfEMT), for the…

Applied Physics · Physics 2020-07-29 Jinxi Xiang , Yonggui Dong , Yunjie Yang

Fourier light-field microscopy (FLFM) uses a micro-lens array (MLA) to segment the Fourier Plane of the microscopic objective lens to generate multiple two-dimensional perspective views, thereby reconstructing the three-dimensional(3D)…

Optics · Physics 2022-08-29 Haixin Huang , Haoyuan Qiu , Hanzhe Wu , Yihong Ji , Heng Li , Bin Yu , Danni Chen , Junle Qu

We demonstrate a simple scheme for high-resolution imaging of nanoplasmonic structures that basically removes most of the resolution limiting allowed light usually transmitted to the far field. This is achieved by implementing a Fourier…

Optics · Physics 2015-06-18 O. Mollet , S. Huant , A. Drezet

This work demonstrates an application of near field indirect microwave holography for the detection of malignant tissues in the human breast in an effective way. The holograms are recorded by two directive antennas aligned along each…

Atomic systems have long provided a useful material platform with unique quantum properties. The efficient light-matter interaction in atomic vapors has led to numerous seminal scientific achievements including accurate and precise…

Optics · Physics 2018-12-05 Liron Stern , Douglas Bopp , Susan Schima , Vincent Maurice , John Kitching

Background: Tumour budding is an independent predictor of metastasis and prognosis in colorectal cancer and is a vital part of the pathology specification report. In a conventional pathological section observation process, pathologists have…

Medical Physics · Physics 2025-03-21 Yiyan Su , Ruiqing Sun , Yajing Wang , Yanfeng xi , Shaohui Zhang

Breaking the diffraction limit in microscopy by utilizing quantum properties of light has been the goal of intense research in the recent years. We propose a quantum superresolution technique based on non-classical emission statistics of…

Optics · Physics 2013-05-30 Osip Schwartz , Dan Oron

This paper reports on advances in optical coherence tomography (OCT) for application in dermatology. Full-field OCT is a particular approach of OCT based on white-light interference microscopy. FF-OCT produces en face tomographic images by…

Medical Physics · Physics 2018-04-06 Olivier Levecq , Arthur Davis , Hicham Azimani , David Siret , Jean-Luc Perrot , Arnaud Dubois