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Multiple imputation (MI) is a popular method for handling missing data. Auxiliary variables can be added to the imputation model(s) to improve MI estimates. However, the choice of which auxiliary variables to include in the imputation model…

For multi-source data, blocks of variable information from certain sources are likely missing. Existing methods for handling missing data do not take structures of block-wise missing data into consideration. In this paper, we propose a…

Methodology · Statistics 2020-04-07 Fei Xue , Annie Qu

We introduce conditional flow matching for imputation (CFMI), a new general-purpose method to impute missing data. The method combines continuous normalising flows, flow-matching, and shared conditional modelling to deal with…

Machine Learning · Computer Science 2025-06-12 Vaidotas Simkus , Michael U. Gutmann

When analyzing incomplete data, is it better to use multiple imputation (MI) or full information maximum likelihood (ML)? In large samples ML is clearly better, but in small samples ML's usefulness has been limited because ML commonly uses…

Methodology · Statistics 2017-03-24 Paul T. von Hippel

Missing values widely exist in many real-world datasets, which hinders the performing of advanced data analytics. Properly filling these missing values is crucial but challenging, especially when the missing rate is high. Many approaches…

Machine Learning · Computer Science 2018-08-07 Hongbao Zhang , Pengtao Xie , Eric Xing

Predictive mean matching (PMM) is a popular imputation strategy that imputes missing values by borrowing observed values from other cases with similar expectations. We show that, unlike other imputation strategies, PMM is not guaranteed to…

Methodology · Statistics 2025-07-01 Paul T. von Hippel

Multiple imputation is widely used for handling missing data in real-world applications. For variable selection on multiply-imputed datasets, however, if selection is performed on each imputed dataset separately, it can result in different…

Methodology · Statistics 2025-08-07 Jungang Zou , Sijian Wang , Qixuan Chen

When studying the association between treatment and a clinical outcome, a parametric multivariable model of the conditional outcome expectation is often used to adjust for covariates. The treatment coefficient of the outcome model targets a…

Methodology · Statistics 2026-05-07 Antonio Remiro-Azócar , Anna Heath , Gianluca Baio

Multiple imputation (MI) has become popular for analyses with missing data in medical research. The standard implementation of MI is based on the assumption of data being missing at random (MAR). However, for missing data generated by…

Methodology · Statistics 2019-01-03 Tra My Pham , James R Carpenter , Tim P Morris , Angela M Wood , Irene Petersen

Incomplete observability of data generates an identification problem. There is no panacea for missing data. What one can learn about a population parameter depends on the assumptions one finds credible to maintain. The credibility of…

Econometrics · Economics 2022-05-17 Charles F. Manski

We present DeepMVI, a deep learning method for missing value imputation in multidimensional time-series datasets. Missing values are commonplace in decision support platforms that aggregate data over long time stretches from disparate…

Machine Learning · Computer Science 2023-06-22 Parikshit Bansal , Prathamesh Deshpande , Sunita Sarawagi

Case-cohort studies are conducted within cohort studies, wherein collection of exposure data is limited to a subset of the cohort, leading to a large proportion of missing data by design. Standard analysis uses inverse probability weighting…

Multiple imputation (MI) is a popular method for dealing with missing values. However, the suitable way for applying clustering after MI remains unclear: how to pool partitions? How to assess the clustering instability when data are…

Methodology · Statistics 2022-05-16 Vincent Audigier , Ndèye Niang

Missing data frequently occurs in datasets across various domains, such as medicine, sports, and finance. In many cases, to enable proper and reliable analyses of such data, the missing values are often imputed, and it is necessary that the…

Variable selection is crucial for sparse modeling in this age of big data. Missing values are common in data, and make variable selection more complicated. The approach of multiple imputation (MI) results in multiply imputed datasets for…

Methodology · Statistics 2025-09-04 Yong-Shiuan Lee

Imputing missing values is common practice in label-free quantitative proteomics. Imputation aims at replacing a missing value with a user-defined one. However, the imputation itself may not be optimally considered downstream of the…

Methodology · Statistics 2022-09-08 Marie Chion , Christine Carapito , Frédéric Bertrand

Missing covariate data commonly occur in epidemiological and clinical research, and are often dealt with using multiple imputation (MI). Imputation of partially observed covariates is complicated if the substantive model is non-linear (e.g.…

Methodology · Statistics 2014-02-17 Jonathan W. Bartlett , Shaun R. Seaman , Ian R. White , James R. Carpenter

Return-to-baseline is an important method to impute missing values or unobserved potential outcomes when certain hypothetical strategies are used to handle intercurrent events in clinical trials. Current return-to-baseline approaches seen…

Methodology · Statistics 2021-11-19 Yongming Qu , Biyue Dai

Multiple imputation has become one of the standard methods in drawing inferences in many incomplete data applications. Applications of multiple imputation in relatively more complex settings, such as high-dimensional clustered data, require…

Methodology · Statistics 2025-04-08 Qiushuang Li , Recai Yucel

Missing data remains a very common problem in large datasets, including survey and census data containing many ordinal responses, such as political polls and opinion surveys. Multiple imputation (MI) is usually the go-to approach for…

Methodology · Statistics 2024-12-25 Chayut Wongkamthong , Olanrewaju Akande