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Using diffusion models to solve inverse problems is a growing field of research. Current methods assume the degradation to be known and provide impressive results in terms of restoration quality and diversity. In this work, we leverage the…

Computer Vision and Pattern Recognition · Computer Science 2025-06-02 Charles Laroche , Andrés Almansa , Eva Coupete

Electron cryomicroscopy (cryo-EM) is an imaging technique widely used in structural biology to determine the three-dimensional structure of biological molecules from noisy two-dimensional projections with unknown orientations. As the…

Numerical Analysis · Mathematics 2025-06-26 Bogdan Toader , Marcus A. Brubaker , Roy R. Lederman

Dramatic increases in the size and dimensionality of many recent data sets make crucial the need for sophisticated methods that can exploit inherent structure and handle missing values. In this article we derive an expectation-maximization…

Methodology · Statistics 2013-09-26 Hunter Glanz , Luis Carvalho

The use of ray projections to reconstruct images is a common technique in medical imaging. Dealing with incomplete data is particularly important when a patient is vulnerable to potentially damaging radiation or is unable to cope with the…

Neural and Evolutionary Computing · Computer Science 2024-06-04 Mohammad Majid al-Rifaie , Tim Blackwell

The most established method of reconstructing neural circuits from animals involves slicing tissue very thin, then taking mosaics of electron microscope (EM) images. To trace neurons across different images and through different sections,…

Quantitative Methods · Quantitative Biology 2013-04-23 Louis K. Scheffer , Bill Karsh , Shiv Vitaladevun

Convolutional neural networks (CNNs) show outstanding performance in many image processing problems, such as image recognition, object detection and image segmentation. Semantic segmentation is a very challenging task that requires…

Computer Vision and Pattern Recognition · Computer Science 2019-07-12 Fan Jia , Jun Liu , Xue-cheng Tai

Regularized inversion methods for image reconstruction are used widely due to their tractability and ability to combine complex physical sensor models with useful regularity criteria. Such methods motivated the recently developed…

Computer Vision and Pattern Recognition · Computer Science 2018-06-14 Gregery T. Buzzard , Stanley H. Chan , Suhas Sreehari , Charles A. Bouman

We introduce a new algorithm for complex image reconstruction with separate regularization of the image magnitude and phase. This optimization problem is interesting in many different image reconstruction contexts, although is nonconvex and…

Signal Processing · Electrical Eng. & Systems 2020-12-17 Yunsong Liu , Justin P. Haldar

We present two methods that combine image reconstruction and edge detection in computed tomography (CT) scans. Our first method is as an extension of the prominent filtered backprojection algorithm. In our second method we employ…

Numerical Analysis · Mathematics 2021-10-14 Jürgen Frikel , Simon Göppel , Markus Haltmeier

We propose a model-based image reconstruction method for photoacoustic tomography(PAT) involving a novel form of regularization and demonstrate its ability to recover good quality images from significantly reduced size datasets. The…

Image and Video Processing · Electrical Eng. & Systems 2020-12-29 Nadaparambil Aravindakshan Rejesh , Sandeep Kumar Kalva , Manojit Pramanik , Muthuvel Arigovindan

The iterative refinement method (IRM) has been very successfully applied in many different fields for examples the modern quantum chemical calculation and CT image reconstruction. It is proved that the refinement method can create an exact…

Medical Physics · Physics 2015-12-23 Kang Yang , Kevin Yang , Xintie Yang , Shuang-Ren Zhao

Processing high-volume, streaming data is increasingly common in modern statistics and machine learning, where batch-mode algorithms are often impractical because they require repeated passes over the full dataset. This has motivated…

We presented a new 3D refinement method for Cryo-EM single particle analysis which can improve the resolution of final electron density map in this paper. We proposed to enforce both sparsity and smoothness to improve the regularity of…

Image and Video Processing · Electrical Eng. & Systems 2020-03-12 Zhenwei Luo

Advances in instrumentation and computation have enabled increasingly sophisticated tomographic reconstruction methods. However, existing evaluation practices -- often based on simple phantoms and global image metrics -- are limited in…

Medical Physics · Physics 2026-04-06 Anna Frixou , Theodoros Leontiou , Efstathios Stiliaris , Costas N. Papanicolas

Training end-to-end unrolled iterative neural networks for SPECT image reconstruction requires a memory-efficient forward-backward projector for efficient backpropagation. This paper describes an open-source, high performance Julia…

Signal Processing · Electrical Eng. & Systems 2023-04-04 Zongyu Li , Yuni K. Dewaraja , Jeffrey A. Fessler

The Expectation Maximization (EM) algorithm is of key importance for inference in latent variable models including mixture of regressors and experts, missing observations. This paper introduces a novel EM algorithm, called…

Machine Learning · Computer Science 2020-12-04 Gersende Fort , Eric Moulines , Hoi-To Wai

The total variation (TV) regularization has phenomenally boosted various variational models for image processing tasks. We propose to combine the backward diffusion process in the earlier literature of image enhancement with the TV…

Image and Video Processing · Electrical Eng. & Systems 2023-06-14 Congpei An , Hao-Ning Wu , Xiaoming Yuan

While there are many studies on weight regularization, the study on structure regularization is rare. Many existing systems on structured prediction focus on increasing the level of structural dependencies within the model. However, this…

Machine Learning · Computer Science 2015-02-02 Xu Sun

With the advent of infrared long-baseline interferometers with more than two telescopes, both the size and the completeness of interferometric data sets have significantly increased, allowing images based on models with no a priori…

Instrumentation and Methods for Astrophysics · Physics 2015-05-28 Stéphanie Renard , Eric Thiébaut , Fabien Malbet

We introduce the spiked mixture model (SMM) to address the problem of estimating a set of signals from many randomly scaled and noisy observations. Subsequently, we design a novel expectation-maximization (EM) algorithm to recover all…

Machine Learning · Statistics 2026-01-26 Paul-Louis Delacour , Sander Wahls , Jeffrey M. Spraggins , Lukasz Migas , Raf Van de Plas
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