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This proof-of-concept study introduces a novel multimodal framework combining synchronized EEG-fNIRS modalities with neuronal avalanche analysis to identify early network dysfunction in Alzheimer's disease. The approach leverages…

Neurons and Cognition · Quantitative Biology 2026-03-25 Eva Guttmann-Flury , Yun-Hsuan Chen , Qiaoyuan Xiang , Hao Zhang , Mohamad Sawan

This paper studies the problem of jointly estimating multiple network processes driven by a common unknown input, thus effectively generalizing the classical blind multi-channel identification problem to graphs. More precisely, we model…

Signal Processing · Electrical Eng. & Systems 2019-10-01 Yu Zhu , Fernando J. Iglesias , Antonio G. Marques , Santiago Segarra

Introspection of deep supervised predictive models trained on functional and structural brain imaging may uncover novel markers of Alzheimer's disease (AD). However, supervised training is prone to learning from spurious features (shortcut…

Machine Learning · Computer Science 2022-05-24 Alex Fedorov , Lei Wu , Tristan Sylvain , Margaux Luck , Thomas P. DeRamus , Dmitry Bleklov , Sergey M. Plis , Vince D. Calhoun

In this paper, we first propose a Bayesian neighborhood selection method to estimate Gaussian Graphical Models (GGMs). We show the graph selection consistency of this method in the sense that the posterior probability of the true model…

Applications · Statistics 2015-07-08 Zhixiang Lin , Tao Wang , Can Yang , Hongyu Zhao

Alzheimer's disease is a progressive neurodegenerative disorder that primarily affects cognitive functions such as memory, thinking, and behavior. In this disease, there is a critical phase, mild cognitive impairment, that is really…

Signal Processing · Electrical Eng. & Systems 2024-04-02 Arezoo Borji , Taha-Hossein Hejazi , Abbas Seifi

Objective: This paper presents an Alzheimer's disease (AD) detection method based on learning structural similarity between Magnetic Resonance Images (MRIs) and representing this similarity as a graph. Methods: We construct the similarity…

Computer Vision and Pattern Recognition · Computer Science 2021-03-01 Kuo Yang , Emad A. Mohammed , Behrouz H. Far

We study the problem of variance estimation in general graph-structured problems. First, we develop a linear time estimator for the homoscedastic case that can consistently estimate the variance in general graphs. We show that our estimator…

Statistics Theory · Mathematics 2024-02-20 Oscar Hernan Madrid Padilla

We propose a new algorithm for solving the graph-fused lasso (GFL), a method for parameter estimation that operates under the assumption that the signal tends to be locally constant over a predefined graph structure. Our key insight is to…

Machine Learning · Statistics 2015-06-02 Wesley Tansey , James G. Scott

Large-scale collaborative analysis of brain imaging data, in psychiatry and neu-rology, offers a new source of statistical power to discover features that boost ac-curacy in disease classification, differential diagnosis, and outcome…

Functional magnetic resonance imaging (fMRI) is a commonly used technique to measure neural activation. Its application has been particularly important in identifying underlying neurodegenerative conditions such as Parkinson's, Alzheimer's,…

Neurons and Cognition · Quantitative Biology 2024-09-09 Jiaxing Xu , Qingtian Bian , Xinhang Li , Aihu Zhang , Yiping Ke , Miao Qiao , Wei Zhang , Wei Khang Jeremy Sim , Balázs Gulyás

In this paper, we propose MGNet, a simple and effective multiplex graph convolutional network (GCN) model for multimodal brain network analysis. The proposed method integrates tensor representation into the multiplex GCN model to extract…

Computer Vision and Pattern Recognition · Computer Science 2021-08-03 Zhaoming Kong , Lichao Sun , Hao Peng , Liang Zhan , Yong Chen , Lifang He

Multimodal neuroimage can provide complementary information about the dementia, but small size of complete multimodal data limits the ability in representation learning. Moreover, the data distribution inconsistency from different…

Computer Vision and Pattern Recognition · Computer Science 2021-07-22 Qiankun Zuo , Baiying Lei , Yanyan Shen , Yong Liu , Zhiguang Feng , Shuqiang Wang

This paper explores deterioration in Alzheimers Disease using Machine Learning. Subjects were split into two datasets based on baseline diagnosis (Cognitively Normal, Mild Cognitive Impairment), with outcome of deterioration at final visit…

Machine Learning · Computer Science 2023-06-21 Henry Musto , Daniel Stamate , Ida Pu , Daniel Stahl

This paper considers the problem of networks reconstruction from heterogeneous data using a Gaussian Graphical Mixture Model (GGMM). It is well known that parameter estimation in this context is challenging due to large numbers of variables…

Machine Learning · Statistics 2013-10-08 Anani Lotsi , Ernst Wit

In this paper, we consider the joint task of simultaneously optimizing (i) the weights of a deep neural network, (ii) the number of neurons for each hidden layer, and (iii) the subset of active input features (i.e., feature selection).…

Machine Learning · Statistics 2017-02-14 Simone Scardapane , Danilo Comminiello , Amir Hussain , Aurelio Uncini

This paper proposes a penalized composite likelihood method for model selection in colored graphical Gaussian models. The method provides a sparse and symmetry-constrained estimator of the precision matrix, and thus conducts model selection…

Methodology · Statistics 2020-04-06 Qiong Li , Xiaoying Sun , Nanwei Wang

Multimodal data analysis can lead to more accurate diagnoses of brain disorders due to the complementary information that each modality adds. However, a major challenge of using multimodal datasets in the neuroimaging field is incomplete…

Image and Video Processing · Electrical Eng. & Systems 2025-08-14 Reihaneh Hassanzadeh , Anees Abrol , Hamid Reza Hassanzadeh , Vince D. Calhoun

We introduce LearnAD, a neuro-symbolic method for predicting Alzheimer's disease from brain magnetic resonance imaging data, learning fully interpretable rules. LearnAD applies statistical models, Decision Trees, Random Forests, or GNNs to…

Machine Learning · Computer Science 2026-01-06 Thomas Andrews , Mark Law , Sara Ahmadi-Abhari , Alessandra Russo

Motivation: In recent years, the availability of multi-omics data has increased substantially. Multi-omics data integration methods mainly aim to leverage different molecular layers to gain a complete molecular description of biological…

Methodology · Statistics 2026-01-28 Alessio Albanese , Wouter Kohlen , Pariya Behrouzi

We propose a unified optimization framework that combines neural networks with dictionary learning to model complex interactions between resting state functional MRI and behavioral data. The dictionary learning objective decomposes patient…

Machine Learning · Computer Science 2024-11-21 Niharika Shimona D'Souza , Mary Beth Nebel , Nicholas Wymbs , Stewart Mostofsky , Archana Venkataraman