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We study the dynamics of membrane vesicle motor transport into dendritic spines, which are bulbous intracellular compartments in neurons that play a key role in transmitting signals between neurons. We consider the stochastic analog of the…

Subcellular Processes · Quantitative Biology 2022-05-17 Youngmin Park , Prashant Singh , Thomas G. Fai

We present a linear, second order fully discrete numerical scheme on a staggered grid for a thermodynamically consistent hydrodynamic phase field model of binary compressible fluid flow mixtures derived from the generalized Onsager…

Numerical Analysis · Mathematics 2019-07-24 Xueping Zhao , Qi Wang

High-dimensional recordings of dynamical processes are often characterized by a much smaller set of effective variables, evolving on low-dimensional manifolds. Identifying these latent dynamics requires solving two intertwined problems:…

Machine Learning · Computer Science 2026-01-21 Manuel Hinz , Maximilian Mauel , Patrick Seifner , David Berghaus , Kostadin Cvejoski , Ramses J. Sanchez

Stochastic gradient descent (SGD) has been widely used in machine learning due to its computational efficiency and favorable generalization properties. Recently, it has been empirically demonstrated that the gradient noise in several deep…

Machine Learning · Statistics 2019-06-24 Thanh Huy Nguyen , Umut Şimşekli , Mert Gürbüzbalaban , Gaël Richard

We study the noisy nonequilibrium dynamics of a conserved density that is driven by a fluctuating surface governed by the conserved Kardar-Parisi-Zhang equation. We uncover the universal scaling properties of the conserved density. We…

Statistical Mechanics · Physics 2018-02-14 Tirthankar Banerjee , Abhik Basu

We present a statistical learning framework for robust identification of partial differential equations from noisy spatiotemporal data. Extending previous sparse regression approaches for inferring PDE models from simulated data, we address…

Numerical Analysis · Mathematics 2019-07-19 Suryanarayana Maddu , Bevan L. Cheeseman , Ivo F. Sbalzarini , Christian L. Müller

A new class of stochastic field models is constructed using nested stochastic partial differential equations (SPDEs). The model class is computationally efficient, applicable to data on general smooth manifolds, and includes both the…

Applications · Statistics 2011-04-19 David Bolin , Finn Lindgren

Stochastic differential equations (SDEs) are popular tools to analyse time series data in many areas, such as mathematical finance, physics, and biology. They provide a mechanistic description of the phenomeon of interest, and their…

Methodology · Statistics 2021-02-01 Théo Michelot , Richard Glennie , Catriona Harris , Len Thomas

When solving partial differential equations (PDEs), classical numerical methods often require fine mesh grids and small time stepping to meet stability, consistency, and convergence conditions, leading to high computational cost. Recently,…

This paper presents a geometric-variational approach to continuous and discrete mechanics and field theories. Using multisymplectic geometry, we show that the existence of the fundamental geometric structures as well as their preservation…

Differential Geometry · Mathematics 2025-10-20 Jerrold E. Marsden , George W. Patrick , Steve Shkoller

A variety of real-world applications are modeled via hyperbolic conservation laws. To account for uncertainties or insufficient measurements, random coefficients may be incorporated. These random fields may depend discontinuously on the…

Numerical Analysis · Mathematics 2021-07-02 Lukas Brencher , Andrea Barth

This paper introduces a new approach to Large-Eddy Simulation (LES) where subgrid-scale (SGS) dissipation is applied proportionally to the degree of local spectral broadening, hence mitigated or deactivated in regions dominated by…

Computational Engineering, Finance, and Science · Computer Science 2018-02-14 Jean-Baptiste Chapelier , Bono Wasistho , Carlo Scalo

In this paper, we discuss information-theoretic tools for obtaining optimized coarse-grained molecular models for both equilibrium and non-equilibrium molecular dynamics. The latter are ubiquitous in physicochemical and biological…

Numerical Analysis · Mathematics 2016-04-20 Vagelis Harmandaris , Evangelia Kalligiannaki , Markos A. Katsoulakis , Petr Plecháč

We propose a sampling algorithm relying on a collective variable (CV) of mid-size dimension modelled by a normalizing flow and using non-equilibrium dynamics to propose full configurational moves from the proposition of a refreshed value of…

Statistical Mechanics · Physics 2024-07-29 Samuel Tamagnone , Alessandro Laio , Marylou Gabrié

We present a new approach to coarse-graining of variables describing dust flow in GR. It is based on assigning quasi-local shear, twist and expansion to 2-dimensional surfaces with the help of isometric embeddings into the 3-dimensional…

General Relativity and Quantum Cosmology · Physics 2015-05-14 Mikolaj Korzynski

The weakly compressible Smoothed Particle Hydrodynamics (SPH) is known to suffer from the pressure oscillation, which would undermine the simulation stability and accuracy. To address this issue, we propose a generalized density dissipation…

Fluid Dynamics · Physics 2023-08-30 Bo Xue Zheng , Zhi Wen Cai , Pei Dong Zhao , Xiao Yang Xu , Tak Shing Chan , Peng Yu

Numerous processes across both the physical and biological sciences are driven by diffusion. Partial differential equations (PDEs) are a popular tool for modelling such phenomena deterministically, but it is often necessary to use…

Quantitative Methods · Quantitative Biology 2016-05-25 Paul R. Taylor , Ruth E. Baker , Matthew J. Simpson , Christian A. Yates

Strongly nonlinear flows, which commonly arise in geophysical and engineering turbulence, are characterized by persistent and intermittent energy transfer between various spatial and temporal scales. These systems are difficult to model and…

Dynamical Systems · Mathematics 2022-01-25 Hassan Arbabi , Themistoklis Sapsis

This study addresses the inverse problem of parameter estimation for Stochastic Differential Equations (SDEs) by minimizing a regularized discrepancy functional via Stochastic Gradient Descent (SGD). To achieve computational efficiency, we…

Machine Learning · Statistics 2026-03-31 Francisco Delgado-Vences , José Julián Pavón-Español , Arelly Ornelas

Diffeomorphic matching (only one of several names for this technique) is a technique for non-rigid registration of curves and surfaces in which the curve or surface is embedded in the flow of a time-series of vector fields. One seeks the…

Numerical Analysis · Mathematics 2009-11-13 C. J. Cotter