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Clustering analysis is one of the most widely used statistical tools in many emerging areas such as microarray data analysis. For microarray and other high-dimensional data, the presence of many noise variables may mask underlying…

Machine Learning · Statistics 2008-03-26 Benhuai Xie , Wei Pan , Xiaotong Shen

Regression by composition provides a flexible framework for constructing conditional distributions through sequential group actions. However, when multiple flows act on the same distribution, the model becomes non-identifiable, leading to…

Methodology · Statistics 2026-03-30 Safaa K. Kadhem

In recent years, bilevel approaches have become very popular to efficiently estimate high-dimensional hyperparameters of machine learning models. However, to date, binary parameters are handled by continuous relaxation and rounding…

Machine Learning · Computer Science 2025-03-20 Sara Venturini , Marianna de Santis , Jordan Patracone , Francesco Rinaldi , Saverio Salzo , Martin Schmidt

We propose a two-stage penalized least squares method to build large systems of structural equations based on the instrumental variables view of the classical two-stage least squares method. We show that, with large numbers of endogenous…

Methodology · Statistics 2018-07-31 Chen Chen , Min Ren , Min Zhang , Dabao Zhang

We consider nonlinear mixed effects models including high-dimensional covariates to model individual parameters variability. The objective is to identify relevant covariates among a large set under sparsity assumption and to estimate model…

Statistics Theory · Mathematics 2025-08-06 Antoine Caillebotte , Estelle Kuhn , Sarah Lemler

We present a unified framework for estimation and analysis of generalized additive models in high dimensions. The framework defines a large class of penalized regression estimators, encompassing many existing methods. An efficient…

Methodology · Statistics 2019-03-13 Asad Haris , Noah Simon , Ali Shojaie

Design and analysis of cluster randomized trials must take into account correlation among outcomes from the same clusters. When applying standard generalized estimating equations (GEE), the first-order (e.g. treatment) effects can be…

Methodology · Statistics 2018-04-18 Tom Chen , Eric Tchetgen Tchetgen , Rui Wang

High-dimensional data can often display heterogeneity due to heteroscedastic variance or inhomogeneous covariate effects. Penalized quantile and expectile regression methods offer useful tools to detect heteroscedasticity in…

Methodology · Statistics 2023-03-23 Rebeka Man , Kean Ming Tan , Zian Wang , Wen-Xin Zhou

A penalized maximum likelihood estimation approach is proposed for discrete-time hidden Markov models where covariates affect the observed responses and serial dependence is considered. The proposed penalized maximum likelihood method…

Methodology · Statistics 2025-07-04 Luca Brusa , Fulvia Pennoni , Francesco Bartolucci , Romina Peruilh Bagolini

We investigate the choice of tuning parameters for a Bayesian multi-level group lasso model developed for the joint analysis of neuroimaging and genetic data. The regression model we consider relates multivariate phenotypes consisting of…

Machine Learning · Statistics 2016-03-29 Farouk S. Nathoo , Keelin Greenlaw , Mary Lesperance

We introduce a novel class of variable selection penalties called TWIN, which provides sensible data-adaptive penalization. Under a linear sparsity regime and random Gaussian designs we show that penalties in the TWIN class have a high…

Methodology · Statistics 2018-06-07 Xiaowu Dai , Jared D. Huling

Model-assisted estimation with complex survey data is an important practical problem in survey sampling. When there are many auxiliary variables, selecting significant variables associated with the study variable would be necessary to…

Methodology · Statistics 2020-04-01 Shonosuke Sugasawa , Jae Kwang Kim

In this article, we propose a penalized clustering method for large scale data with multiple covariates through a functional data approach. In the proposed method, responses and covariates are linked together through nonparametric…

Methodology · Statistics 2008-01-17 Ping Ma , Wenxuan Zhong

Here we propose a novel searching scheme for a tuning parameter in high-dimensional penalized regression methods to address variable selection and modeling when sample sizes are limited compared to the data dimensions. Our method is…

Quantitative Methods · Quantitative Biology 2020-02-11 Tao Jiang , Stephanie J. London , Mi Kyeong Lee , Josyf C. Mychaleckyj , Alison A. Motsinger-Reif

We propose a penalized likelihood method to fit the linear discriminant analysis model when the predictor is matrix valued. We simultaneously estimate the means and the precision matrix, which we assume has a Kronecker product…

Machine Learning · Statistics 2016-10-31 Aaron J. Molstad , Adam J. Rothman

We present an estimation procedure for nonlinear mixed-effects models in which the population trajectory is represented by penalized splines and adapted to individuals via subject-specific transformation parameters. By exploiting the mixed…

Methodology · Statistics 2026-03-13 Matteo D'Alessandro , Magne Thoresen , Øystein Sørensen

We revisit the generalized hyperbolic (GH) distribution and its nested models. These include widely used parametric choices like the multivariate normal, skew-t, Laplace, and several others. We also introduce the multiple-choice LASSO, a…

Methodology · Statistics 2023-07-13 Luca Bagnato , Alessio Farcomeni , Antonio Punzo

Applications of structural equation models (SEMs) are often restricted to linear associations between variables. Maximum likelihood (ML) estimation in non-linear models may be complex and require numerical integration. Furthermore, ML…

Methodology · Statistics 2019-03-15 Klaus Kähler Holst , Esben Budtz-Jørgensen

We investigate methods for penalized regression in the presence of missing observations. This paper introduces a method for estimating the parameters which compensates for the missing observations. We first, derive an unbiased estimator of…

Applications · Statistics 2013-10-09 Yunjin Choi , Robert Tibshirani

The Ising model is a useful tool for studying complex interactions within a system. The estimation of such a model, however, is rather challenging, especially in the presence of high-dimensional parameters. In this work, we propose…

Statistics Theory · Mathematics 2012-08-20 Lingzhou Xue , Hui Zou , Tianxi Cai
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