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Chemical reactions occur in energy, environmental, biological, and many other natural systems, and the inference of the reaction networks is essential to understand and design the chemical processes in engineering and life sciences. Yet,…

Molecular Networks · Quantitative Biology 2021-01-22 Weiqi Ji , Sili Deng

This study develops an algorithm to reproduce reaction route maps (RRMs) in shape space from the outputs of potential search algorithms. To demonstrate this, GRRM is utilized as a potential search algorithm but the proposed algorithm should…

Prediction of complete step-by-step chemical reaction mechanisms (CRMs) remains a major challenge. Whereas the traditional approaches in CRM tasks rely on expert-driven experiments or costly quantum chemical computations, contemporary deep…

Chemical Physics · Physics 2025-12-11 Manajit Das , Ajnabiul Hoque , Mayank Baranwal , Raghavan B. Sunoj

Inference is a fundamental reasoning technique in probability theory. When applied to a large joint distribution, it involves updating with evidence (conditioning) in one or more components (variables) and computing the outcome in other…

Logic in Computer Science · Computer Science 2026-03-03 Bart Jacobs , Márk Széles , Dario Stein

We pose 3D scene-understanding as a problem of parsing in a grammar. A grammar helps us capture the compositional structure of real-word objects, e.g., a chair is composed of a seat, a back-rest and some legs. Having multiple rules for an…

Computer Vision and Pattern Recognition · Computer Science 2012-11-09 Abhishek Anand , Sherwin Li

Reaction diagram parsing is the task of extracting reaction schemes from a diagram in the chemistry literature. The reaction diagrams can be arbitrarily complex, thus robustly parsing them into structured data is an open challenge. In this…

Computation and Language · Computer Science 2023-05-22 Yujie Qian , Jiang Guo , Zhengkai Tu , Connor W. Coley , Regina Barzilay

We propose a unified, human-readable, machine-processable novel syntax/notation designed to comprehensively describe reactions, molecules and excitation states. Our notation resolves inconsistencies in existing data representations and…

Computational Physics · Physics 2025-04-15 Dan Andrei Ciubotaru , Michele Renda , Călin Alexa

Molecular representation is a critical element in our understanding of the physical world and the foundation for modern molecular machine learning. Previous molecular machine learning models have employed strings, fingerprints, global…

Machine Learning · Computer Science 2025-05-28 Daniil A. Boiko , Thiago Reschützegger , Benjamin Sanchez-Lengeling , Samuel M. Blau , Gabe Gomes

Local interactions among biomolecules, and the role played by their environment, have gained increasing attention in modelling biochemical reactions. By defining the automaton of molecular perceptions, we explore an agent-based…

Computational Engineering, Finance, and Science · Computer Science 2021-11-24 Stefano Maestri , Emanuela Merelli

In this work, the rate law for inhomogeneous concentration distributions has been formulated, by applying spatial integration over the products of species concentrations. Reaction rates for typical reactions have been investigated by…

Chemical Physics · Physics 2025-12-24 Xiang-Yuan Li , Xin-Yu Zhang , ChuanFeng Yue

We seek to automate the design of molecules based on specific chemical properties. In computational terms, this task involves continuous embedding and generation of molecular graphs. Our primary contribution is the direct realization of…

Machine Learning · Computer Science 2019-04-01 Wengong Jin , Regina Barzilay , Tommi Jaakkola

Predicting and enhancing inherent properties based on molecular structures is paramount to design tasks in medicine, materials science, and environmental management. Most of the current machine learning and deep learning approaches have…

Machine Learning · Computer Science 2024-04-08 Zachary R. Fox , Ayana Ghosh

Accurate prediction of molecular properties in complex chemical systems is crucial for accelerating material discovery and chemical innovation. However, current computational methods often struggle to capture the intricate compositional…

Chemical Physics · Physics 2025-09-24 Jinming Fan , Chao Qian , Shaodong Zhou

We are living in a world which is getting more and more interconnected and, as physiological effect, the interaction between the entities produces more and more information. This high throughput generation calls for techniques able to…

Data Structures and Algorithms · Computer Science 2018-12-17 Francesco Pelosin

Sampled structure sequences obtained, for instance, from real-time reactivity explorations or first-principles molecular dynamics simulations contain valuable information about chemical reactivity. Eventually, such sequences allow for the…

Chemical Physics · Physics 2018-04-25 Michael A. Heuer , Alain C. Vaucher , Moritz P. Haag , Markus Reiher

Thermodynamic aspects of chemical reactions have a long history in the Physical Chemistry literature. In particular, biochemical cycles - the building-blocks of biochemical systems - require a source of energy to function. However, although…

Quantitative Methods · Quantitative Biology 2018-08-14 Peter J. Gawthrop , Edmund J. Crampin

Directed acyclic graphs (DAGs) are a class of graphs commonly used in practice, with examples that include electronic circuits, Bayesian networks, and neural architectures. While many effective encoders exist for DAGs, it remains…

Machine Learning · Computer Science 2025-05-30 Michael Sun , Orion Foo , Gang Liu , Wojciech Matusik , Jie Chen

Reaction rate equations are ordinary differential equations that are frequently used to describe deterministic chemical kinetics at the macroscopic scale. At the microscopic scale, the chemical kinetics is stochastic and can be captured by…

Soft Condensed Matter · Physics 2021-05-12 Ariana Torres-Knoop , Ivan Kryven

Compositional generalization -- the ability to understand and generate novel combinations of learned concepts -- enables models to extend their capabilities beyond limited experiences. While effective, the data structures and principles…

Machine Learning · Computer Science 2025-12-12 Lingjing Kong , Shaoan Xie , Yang Jiao , Yetian Chen , Yanhui Guo , Simone Shao , Yan Gao , Guangyi Chen , Kun Zhang

Knowledge graphs (KGs) often contain sufficient information to support the inference of new facts. Identifying logical rules not only improves the completeness of a knowledge graph but also enables the detection of potential errors, reveals…

Computation and Language · Computer Science 2025-08-01 Nasim Shirvani-Mahdavi , Devin Wingfield , Amin Ghasemi , Chengkai Li
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