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A large number of inorganic and organic compounds are able to bind DNA and form complexes, among which drug-related molecules are important. Chromatin accessibility changes not only directly affects drug-DNA interactions, but also promote…

Genomics · Quantitative Biology 2022-04-07 Yikang Zhang , Xiaomin Chu , Yelu Jiang , Hongjie Wu , Lijun Quan

The use of balanced crossover operators in Genetic Algorithms (GA) ensures that the binary strings generated as offsprings have the same Hamming weight of the parents, a constraint which is sought in certain discrete optimization problems.…

Neural and Evolutionary Computing · Computer Science 2020-04-24 Luca Manzoni , Luca Mariot , Eva Tuba

Genetic Algorithms are a popular set of optimization algorithms often used to aid software testing. However, no work has been done to apply systematic software testing techniques to genetic algorithms because of the stochasticity and the…

Software Engineering · Computer Science 2018-08-06 Janette Rounds , Upulee Kanewala

Semantic parsing is the problem of deriving machine interpretable meaning representations from natural language utterances. Neural models with encoder-decoder architectures have recently achieved substantial improvements over traditional…

Computation and Language · Computer Science 2019-09-30 Huseyin A. Inan , Gaurav Singh Tomar , Huapu Pan

Evolutionary algorithms are wildly used in unmanned aerial vehicle path planning for their flexibility and effectiveness. Nevertheless, they are so sensitive to the change of environment that can't adapt to all scenarios. Due to this…

Neural and Evolutionary Computing · Computer Science 2022-04-08 Jiabin Lou , Rong Ding , Wenjun Wu

In this paper, we study the influence of the selective pressure on the performance of cellular genetic algorithms. Cellular genetic algorithms are genetic algorithms where the population is embedded on a toroidal grid. This structure makes…

Artificial Intelligence · Computer Science 2008-12-18 David Simoncini , Philippe Collard , Sébastien Verel , Manuel Clergue

Automatic code generation for low-dimensional geometric algorithms is capable of producing efficient low-level software code through a high-level geometric domain specific language. Geometric Algebra (GA) is one of the most suitable…

Mathematical Software · Computer Science 2016-07-19 Ahmad Hosney Awad Eid

Coverage of image features play an important role in many vision algorithms since their distribution affect the estimated homography. This paper presents a Genetic Algorithm (GA) in order to select the optimal set of features yielding…

Computer Vision and Pattern Recognition · Computer Science 2017-04-21 Erkan Bostanci

Despite many successful applications, Cartesian Genetic Programming (CGP) suffers from limited scalability, especially when used for evolutionary circuit design. Considering the multiplier design problem, for example, the 5x5-bit multiplier…

Neural and Evolutionary Computing · Computer Science 2020-04-24 David Hodan , Vojtech Mrazek , Zdenek Vasicek

3D computer-assisted corrective osteotomy has become the state-of-the-art for surgical treatment of complex bone deformities. Despite available technologies, the automatic generation of clinically acceptable, ready-to-use preoperative…

This paper presents a new type of genetic algorithm for the set covering problem. It differs from previous evolutionary approaches first because it is an indirect algorithm, i.e. the actual solutions are found by an external decoder…

Neural and Evolutionary Computing · Computer Science 2010-07-05 Uwe Aickelin

Mathematical formulas serve as a language through which humans communicate with nature. Discovering mathematical laws from scientific data to describe natural phenomena has been a long-standing pursuit of humanity for centuries. In the…

Artificial Intelligence · Computer Science 2026-05-14 Yanjie Li , Liping Zhang , Min Wu , Weijun Li , Lina Yu , Jingyi Liu , Yusong Deng , Mingzhu Wan , Xin Ning

Premature convergence is one of the important issues while using Genetic Programming for data modeling. It can be avoided by improving population diversity. Intelligent genetic operators can help to improve the population diversity.…

Neural and Evolutionary Computing · Computer Science 2013-04-15 Hardik M. Parekh , Vipul K. Dabhi

Robots are moving towards applications in less structured environments, but their model-based controllers are challenged by the tasks' complexity and intrinsic environmental unpredictability. Studying biological motor control can provide…

Robotics · Computer Science 2022-03-04 Carlo Tiseo , Sydney Rebecca Charitos , Michael Mistry

Constructing transferable descriptors for conformation representation of molecular and biological systems finds numerous applications in drug discovery, learning-based molecular dynamics, and protein mechanism analysis. Geometric graph…

Machine Learning · Computer Science 2024-10-30 Zihan Pengmei , Zhengyuan Shen , Zichen Wang , Marcus Collins , Huzefa Rangwala

Geometric programming problem is a powerful tool for solving some special type non-linear programming problems. It has a wide range of applications in optimization and engineering for solving some complex optimization problems. Many…

Data Structures and Algorithms · Computer Science 2010-03-25 A. K. Ojha , K. K. Biswal

Operator learning offers a powerful paradigm for solving parametric partial differential equations (PDEs), but scaling probabilistic neural operators such as the recently proposed Gaussian Processes Operators (GPOs) to high-dimensional,…

Machine Learning · Statistics 2025-06-23 Sawan Kumar , Tapas Tripura , Rajdip Nayek , Souvik Chakraborty

Advances in large language models (LLMs) have recently opened new and promising avenues for small-molecule drug discovery. Yet existing LLM-based approaches for molecular generation often suffer from high rates of invalid and low-quality…

Machine Learning · Computer Science 2026-05-15 Andrew Y. Zhou , Sharvaree Vadgama , Sumanth Varambally , Peter Eckmann , Michael K. Gilson , Rose Yu

Decision trees are a crucial class of models offering robust predictive performance and inherent interpretability across various domains, including healthcare, finance, and logistics. However, current tree induction methods often face…

Machine Learning · Computer Science 2025-03-19 Tennison Liu , Nicolas Huynh , Mihaela van der Schaar

Accurate and robust tracking and reconstruction of the surgical scene is a critical enabling technology toward autonomous robotic surgery. Existing algorithms for 3D perception in surgery mainly rely on geometric information, while we…

Image and Video Processing · Electrical Eng. & Systems 2023-02-21 Shan Lin , Albert J. Miao , Jingpei Lu , Shunkai Yu , Zih-Yun Chiu , Florian Richter , Michael C. Yip