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New powerful tools for tackling life science problems have been created by recent advances in machine learning. The purpose of the paper is to discuss the potential advantages of gene recommendation performed by artificial intelligence…

Quantitative Methods · Quantitative Biology 2023-03-23 Daniele Brambilla , Davide Maria Giacomini , Luca Muscarnera , Andrea Mazzoleni

We present the extention and application of a new unsupervised statistical learning technique--the Partition Decoupling Method--to gene expression data. Because it has the ability to reveal non-linear and non-convex geometries present in…

Quantitative Methods · Quantitative Biology 2015-09-24 Rosemary Braun , Gregory Leibon , Scott Pauls , Daniel Rockmore

Entity Matching (EM) involves identifying different data representations referring to the same entity from multiple data sources and is typically formulated as a binary classification problem. It is a challenging problem in data integration…

Computation and Language · Computer Science 2023-05-31 John Bosco Mugeni , Steven Lynden , Toshiyuki Amagasa , Akiyoshi Matono

Predicting phenotypes from gene expression data is a crucial task in biomedical research, enabling insights into disease mechanisms, drug responses, and personalized medicine. Traditional machine learning and deep learning rely on…

Machine Learning · Computer Science 2025-09-18 Kevin Dradjat , Massinissa Hamidi , Pierre Bartet , Blaise Hanczar

The deep Convolutional Neural Network (CNN) is the state-of-the-art solution for large-scale visual recognition. Following basic principles such as increasing the depth and constructing highway connections, researchers have manually…

Computer Vision and Pattern Recognition · Computer Science 2017-03-07 Lingxi Xie , Alan Yuille

In the field of functional genomics, the analysis of gene expression profiles through Machine and Deep Learning is increasingly providing meaningful insight into a number of diseases. The paper proposes a novel algorithm to perform Feature…

Genomics · Quantitative Biology 2023-03-31 Carlo Adornetto , Gianluigi Greco

We formulate the search for phenomenological models of synaptic plasticity as an optimization problem. We employ Cartesian genetic programming to evolve biologically plausible human-interpretable plasticity rules that allow a given network…

Neural and Evolutionary Computing · Computer Science 2021-02-09 Henrik D. Mettler , Maximilian Schmidt , Walter Senn , Mihai A. Petrovici , Jakob Jordan

Knowledge graphs represent real-world entities and their relations in a semantically-rich structure supported by ontologies. Exploring this data with machine learning methods often relies on knowledge graph embeddings, which produce latent…

Machine Learning · Computer Science 2023-06-23 Rita T. Sousa , Sara Silva , Catia Pesquita

We consider the graph link prediction task, which is a classic graph analytical problem with many real-world applications. With the advances of deep learning, current link prediction methods commonly compute features from subgraphs centered…

Machine Learning · Computer Science 2020-10-21 Lei Cai , Jundong Li , Jie Wang , Shuiwang Ji

The linking genotype to phenotype is the fundamental aim of modern genetics. We focus on study of links between gene expression data and phenotype data through integrative analysis. We propose three approaches. 1) The inherent complexity of…

Quantitative Methods · Quantitative Biology 2015-06-30 Min Xu

Relation linking is essential to enable question answering over knowledge bases. Although there are various efforts to improve relation linking performance, the current state-of-the-art methods do not achieve optimal results, therefore,…

Recently, link prediction has attracted more attentions from various disciplines such as computer science, bioinformatics and economics. In this problem, unknown links between nodes are discovered based on numerous information such as…

Social and Information Networks · Computer Science 2018-07-30 Mohammad Mehdi Keikha , Maseud Rahgozar , Masoud Asadpour

Extreme learning machine (ELM) as a neural network algorithm has shown its good performance, such as fast speed, simple structure etc, but also, weak robustness is an unavoidable defect in original ELM for blended data. We present a new…

Machine Learning · Computer Science 2014-09-24 Bo Han , Bo He , Rui Nian , Mengmeng Ma , Shujing Zhang , Minghui Li , Amaury Lendasse

Community detection in complex networks is a topic of considerable recent interest within the scientific community. For dealing with the problem that genetic algorithm are hardly applied to community detection, we propose a genetic…

Social and Information Networks · Computer Science 2013-03-25 Dongxiao He , Zhe Wang , Bin Yang , Chunguang Zhou

Driven by a large number of potential applications in areas like bioinformatics, information retrieval and social network analysis, the problem setting of inferring relations between pairs of data objects has recently been investigated…

Machine Learning · Statistics 2024-10-30 Willem Waegeman , Tapio Pahikkala , Antti Airola , Tapio Salakoski , Michiel Stock , Bernard De Baets

A very important topic in systems biology is developing statistical methods that automatically find causal relations in gene regulatory networks with no prior knowledge of causal connectivity. Many methods have been developed for time…

Machine Learning · Statistics 2012-08-22 Shohei Shimizu

Inferring missing links or detecting spurious ones based on observed graphs, known as link prediction, is a long-standing challenge in graph data analysis. With the recent advances in deep learning, graph neural networks have been used for…

Social and Information Networks · Computer Science 2023-01-03 Xingping Xian , Tao Wu , Xiaoke Ma , Shaojie Qiao , Yabin Shao , Chao Wang , Lin Yuan , Yu Wu

Entity linking (EL) is the process of linking entity mentions appearing in web text with their corresponding entities in a knowledge base. EL plays an important role in the fields of knowledge engineering and data mining, underlying a…

Computation and Language · Computer Science 2021-09-28 Wei Shen , Yuhan Li , Yinan Liu , Jiawei Han , Jianyong Wang , Xiaojie Yuan

Modeling semantic relevance has always been a challenging and critical task in natural language processing. In recent years, with the emergence of massive amounts of annotated data, it has become feasible to train complex models, such as…

Computation and Language · Computer Science 2025-05-13 Min Li , Chun Yuan

The genetic etiologies of common diseases are highly complex and heterogeneous. Classic statistical methods, such as linear regression, have successfully identified numerous genetic variants associated with complex diseases. Nonetheless,…

Applications · Statistics 2020-10-28 Jinghang Lin , Xiaoran Tong , Chenxi Li , Qing Lu