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We consider a multiscale approach based on immersed methods for the efficient computational modeling of tissues composed of an elastic matrix (in two or three-dimensions) and a thin vascular structure (treated as a co-dimension two…
In recent years, dynamic indentation tests have been shown to be useful both in identification of mechanical properties of biological tissues (such as articular cartilage) and assessing their viability. We consider frictionless flat-ended…
The rebound indentation test consisting of the displacement-controlled and load-controlled stages is considered for a frictionless cylindrical flat-ended indenter. The mechanical behavior of an articular cartilage layer sample is modeled in…
The aim of this paper is to evaluate the train/track induced loads on the substructure by modelling the wheel, at each instant, as a moving sinusoidal pulse applied in a very short period of time. This assumption has the advantage of being…
A novel modelling technique using finite element analysis to mimic the mechanoresponse of cell-laden biomaterial is proposed for the use in bioinks and other tissue engineering applications. Here a hydrogel-based composite biomaterial…
Pressurized elastic shells are ubiquitous in nature and technology, from the outer walls of yeast and bacterial cells to artificial pressure vessels. Indentation measurements simultaneously probe the internal pressure and elastic properties…
An indentation testing method, which utilizes lateral contact of a long cylindrical indenter, is developed for a thin transversely isotropic incompressible elastic film deposited onto a smooth rigid substrate. It is assumed that the…
The packing of elastic bodies has emerged as a paradigm for the study of macroscopic disordered systems. However, progress is hampered by the lack of controlled experiments. Here we consider a model experiment for the isotropic…
Ciliated organs transport viscous fluids through confined ducts, yet how duct morphology and ciliary activity jointly set the limits of flow rate and sustainable pressure remains unclear. Here, we model dense arrays of beating cilia lining…
Measuring the mechanical properties of cells and tissues often involves indentation with a sphere, or compression between two plates. Previously, different theoretical approaches have been developed to retrieve material parameters (e.g.…
The classical continuum models used for the woven fabrics do not fully describe the whole set of phenomena that occur during the testing of those materials. This incompleteness is partially due to the absence of energy terms related to some…
Cardiac muscle tissue exhibits highly non-linear hyperelastic and orthotropic material behavior during passive deformation. Traditional constitutive identification protocols therefore combine multiple loading modes and typically require…
Most measurements of compressive strength of ductile materials have involved Hopkinson-Kolsky bars or Taylor anvils placing samples in uniaxial compression. In these geometries strain is limited by the tendency of the sample to petal, in…
A flexible membrane deforming its shape in time can self-propel in a viscous fluid. Alternatively, if the membrane is anchored, its deformation will lead to fluid transport. Past work in this area focused on situations where the deformation…
We propose a general hybrid physics-informed machine learning framework for modeling nonlinear, history-dependent viscoelastic behavior under multiaxial cyclic loading. The approach is built on a generalized internal state variable-based…
Inside cells, various cargos are transported by teams of molecular motors. Intriguingly, the motors involved generally have opposite pulling directions, and the resulting cargo dynamics is a biased stochastic motion. It is an open question…
This study examines the transverse and longitudinal properties of hard disks confined in narrow channels. Employing an exact mapping of the system onto a one-dimensional polydisperse, nonadditive mixture of hard rods with equal chemical…
Cells within biological tissue are constantly subjected to dynamic mechanical forces. Measuring the internal stress of tissues has proven crucial for our understanding of the role of mechanical forces in fundamental biological processes…
Wrinkling of an inextensible elastic lining of an inner-lined tube under imposed pressure is considered. A simple equation modeling the elastic properties of the lining, the pressure, and the soft-substrate forces is derived. This equation…
This work aims to describe a mathematical model and a numerical method to simulate a thin anisotropic composite membrane moving and deforming in 3D space under a dynamic load of an arbitrary time and space profile. The model and the method…