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This article is addressing a recurrent problem in biology: mining newly built large scale networks. Our approach consists in comparing these new networks to well known ones. The visual backbone of this comparative analysis is provided by a…

Quantitative Methods · Quantitative Biology 2008-12-05 Romain Bourqui , Fabien Jourdan

Given a labeled graph, the frequent-subgraph mining (FSM) problem asks to find all the $k$-vertex subgraphs that appear with frequency greater than a given threshold. FSM has numerous applications ranging from biology to network science, as…

Data Structures and Algorithms · Computer Science 2018-09-11 Cigdem Aslay , Muhammad Anis Uddin Nasir , Gianmarco De Francisci Morales , Aristides Gionis

We review a recent trend in computational systems biology which aims at using pattern recognition algorithms to infer the structure of large-scale biological networks from heterogeneous genomic data. We present several strategies that have…

Quantitative Methods · Quantitative Biology 2008-09-22 Jean-Philippe Vert

The concept of multilayer networks has become recently integrated into complex systems modeling since it encapsulates a very general concept of complex relationships. Biological pathways are an example of complex real-world networks, where…

Human-Computer Interaction · Computer Science 2021-10-12 Hsiang-Yun Wu , Martin Nöllenburg , Ivan Viola

Big graph mining is an important research area and it has attracted considerable attention. It allows to process, analyze, and extract meaningful information from large amounts of graph data. Big graph mining has been highly motivated not…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-05-07 Sabeur Aridhi , Engelbert Mephu Nguifo

Computing subgraph frequencies is a fundamental task that lies at the core of several network analysis methodologies, such as network motifs and graphlet-based metrics, which have been widely used to categorize and compare networks from…

Data Structures and Algorithms · Computer Science 2021-12-30 Pedro Ribeiro , Pedro Paredes , Miguel E. P. Silva , David Aparicio , Fernando Silva

In recent years many algorithms have been developed for finding patterns in graphs and networks. A disadvantage of these algorithms is that they use subgraph isomorphism to determine the support of a graph pattern; subgraph isomorphism is a…

Data Structures and Algorithms · Computer Science 2015-03-19 Anton Dries , Siegfried Nijssen

Network representations of systems from various scientific and societal domains are neither completely random nor fully regular, but instead appear to contain recurring structural building blocks. These features tend to be shared by…

Social and Information Networks · Computer Science 2016-10-20 Ian Barnett , Nishant Malik , Marieke L. Kuijjer , Peter J. Mucha , Jukka-Pekka Onnela

Empirical studies of graphs have contributed enormously to our understanding of complex systems. Known today as network science, what was originally a theoretical study of graphs has grown into a more scientific exploration of communities…

Quantitative Methods · Quantitative Biology 2020-01-01 Ryan E. Langendorf , Debra S. Goldberg

Over the years, frequent subgraphs have been an important sort of targeted patterns in the pattern mining literatures, where most works deal with databases holding a number of graph transactions, e.g., chemical structures of compounds.…

Databases · Computer Science 2013-07-26 Jialong Han , Ji-Rong Wen

One of the most important concepts in biological network analysis is that of network motifs, which are patterns of interconnections that occur in a given network at a frequency higher than expected in a random network. In this work we are…

Discrete Mathematics · Computer Science 2020-05-29 Diego P Rubert , Eloi Araujo , Marco A Stefanes , Jens Stoye , Fábio V Martinez

We discuss the problem of extending data mining approaches to cases in which data points arise in the form of individual graphs. Being able to find the intrinsic low-dimensionality in ensembles of graphs can be useful in a variety of…

Social and Information Networks · Computer Science 2016-12-12 Karthikeyan Rajendran , Assimakis A. Kattis , Alexander Holiday , Risi Kondor , Ioannis G. Kevrekidis

Complex networks or graphs are ubiquitous in sciences and engineering: biological networks, brain networks, transportation networks, social networks, and the World Wide Web, to name a few. Spectral graph theory provides a set of useful…

Statistics Theory · Mathematics 2019-01-23 Subhadeep Mukhopadhyay , Kaijun Wang

A subgraph is constructed by using a subset of vertices and edges of a given graph. There exist many graph properties that are hereditary for subgraphs. Hence, researchers from different communities have paid a great deal of attention in…

Combinatorics · Mathematics 2023-06-06 Kai Siong Yow , Ningyi Liao , Siqiang Luo , Reynold Cheng , Chenhao Ma , Xiaolin Han

Motifs are the fundamental components of complex systems. The topological structure of networks representing complex systems and the frequency and distribution of motifs in these networks are intertwined. The complexities associated with…

Social and Information Networks · Computer Science 2020-05-21 Ali Jazayeri , Christopher C. Yang

Networks are used as highly expressive tools in different disciplines. In recent years, the analysis and mining of temporal networks have attracted substantial attention. Frequent pattern mining is considered an essential task in the…

Social and Information Networks · Computer Science 2021-05-14 Ali Jazayeri , Christopher C. Yang

Many complex systems can be represented as networks, and the problem of network comparison is becoming increasingly relevant. There are many techniques for network comparison, from simply comparing network summary statistics to…

Machine Learning · Statistics 2017-04-04 Anatol E. Wegner , Luis Ospina-Forero , Robert E. Gaunt , Charlotte M. Deane , Gesine Reinert

Hypergraphs, increasingly utilised for modelling complex and diverse relationships in modern networks, gain much attention representing intricate higher-order interactions. Among various challenges, cohesive subgraph discovery is one of the…

Social and Information Networks · Computer Science 2025-12-30 Song Kim , Dahee Kim , Taejoon Han , Junghoon Kim , Hyun Ji Jeong , Jungeun Kim

Retrieving cohesive subgraphs in networks is a fundamental problem in social network analysis and graph data management. These subgraphs can be used for marketing strategies or recommendation systems. Despite the introduction of numerous…

Social and Information Networks · Computer Science 2025-07-16 Dahee Kim , Song Kim , Jeongseon Kim , Junghoon Kim , Kaiyu Feng , Sungsu Lim , Jungeun Kim

Recent technological advancements in data acquisition tools allowed life scientists to acquire multimodal data from different biological application domains. Broadly categorized in three types (i.e., sequences, images, and signals), these…

Quantitative Methods · Quantitative Biology 2020-03-03 Mufti Mahmud , M Shamim Kaiser , Amir Hussain
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