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Stochastic First-Order (SFO) methods have been a cornerstone in addressing a broad spectrum of modern machine learning (ML) challenges. However, their efficacy is increasingly questioned, especially in large-scale applications where…

Machine Learning · Computer Science 2024-08-01 Di Zhang , Suvrajeet Sen

Precision oncology aims to prescribe the optimal cancer treatment to the right patients, maximizing therapeutic benefits. However, identifying patient subgroups that may benefit more from experimental cancer treatments based on randomized…

Methodology · Statistics 2026-01-06 Xingyu Li , Qing Liu , Tony Jiang , Hong Amy Xia , Peng Wei , Brian P. Hobbs

Motivation: Array-based comparative genomic hybridization (arrayCGH) has recently become a popular tool to identify DNA copy number variations along the genome. These profiles are starting to be used as markers to improve prognosis or…

Genomics · Quantitative Biology 2008-01-22 Franck Rapaport , Emmanuel Barillot , Jean-Philippe Vert

The amount of completely sequenced chloroplast genomes increases rapidly every day, leading to the possibility to build large-scale phylogenetic trees of plant species. Considering a subset of close plant species defined according to their…

Artificial Intelligence · Computer Science 2016-09-01 Bassam AlKindy , Bashar Al-Nuaimi , Christophe Guyeux , Jean-François Couchot , Michel Salomon , Reem Alsrraj , Laurent Philippe

Cognitive radio (CR) is to detect the presence of primary users (PUs) reliably in order to reduce the interference to licensed communications. Genetic algorithms (GAs) are well suited for CR optimization problems to increase efficiency of…

Networking and Internet Architecture · Computer Science 2013-04-12 Md. Kamal Hossain , Ayman Abd El-Saleh

Bayesian Optimization (BO) is a key methodology for accelerating molecular discovery by estimating the mapping from molecules to their properties while seeking the optimal candidate. Typically, BO iteratively updates a probabilistic…

Machine Learning · Computer Science 2025-12-17 Qi Chen , Fabio Ramos , Alán Aspuru-Guzik , Florian Shkurti

Random Forests have been one of the most popular bagging methods in the past few decades, especially due to their success at handling tabular datasets. They have been extensively studied and compared to boosting models, like XGBoost, which…

Machine Learning · Computer Science 2024-10-28 Dimitris Bertsimas , Vasiliki Stoumpou

One of the notable fields in studying the genetics of cancer is disease gene identification which affects disease treatment and drug discovery. Many researches have been done in this field. Genome-wide association studies (GWAS) are one of…

Computational Engineering, Finance, and Science · Computer Science 2016-04-27 Zahra Razaghi-Moghadama , Razieh Abdollahia , Sama Goliaeib , Morteza Ebrahimia

The accurate classification of brain tumors from MRI scans is essential for effective diagnosis and treatment planning. This paper presents a weighted ensemble learning approach that combines deep learning and traditional machine learning…

Computer Vision and Pattern Recognition · Computer Science 2026-03-31 Ha Anh Vu

This paper presents a new type of hybrid model for Bayesian optimization (BO) adept at managing mixed variables, encompassing both quantitative (continuous and integer) and qualitative (categorical) types. Our proposed new hybrid models…

Machine Learning · Computer Science 2024-01-22 Hengrui Luo , Younghyun Cho , James W. Demmel , Xiaoye S. Li , Yang Liu

Extracting genetic information from a full range of sequencing data is important for understanding diseases. We propose a novel method to effectively explore the landscape of genetic mutations and aggregate them to predict cancer type. We…

Genomics · Quantitative Biology 2018-10-10 Zexian Zeng , Andy Vo , Chengsheng Mao , Susan E Clare , Seema A Khan , Yuan Luo

This work proposes a unified framework to leverage biological information in network propagation-based gene prioritization algorithms. Preliminary results on breast cancer data show significant improvements over state-of-the-art baselines,…

Molecular Networks · Quantitative Biology 2020-02-18 Michele Gentili , Leonardo Martini , Manuela Petti , Lorenzo Farina , Luca Becchetti

We propose a novel method designed for large-scale regression problems, namely the two-stage best-scored random forest (TBRF). "Best-scored" means to select one regression tree with the best empirical performance out of a certain number of…

Machine Learning · Statistics 2019-05-10 Hanyuan Hang , Yingyi Chen , Johan A. K. Suykens

In this paper, we analyze the Wisconsin Diagnostic Breast Cancer Data using Machine Learning classification techniques, such as the SVM, Bayesian Logistic Regression (Variational Approximation), and K-Nearest-Neighbors. We describe each…

Machine Learning · Statistics 2018-07-05 Reihaneh Entezari

Bilinear matrix inequality (BMI) problems in system and control designs are investigated in this paper. A solution method of reduction of variables (MRVs) is proposed. This method consists of a principle of variable classification, a…

Systems and Control · Electrical Eng. & Systems 2026-01-16 Wei-Yu Chiu

Feature selection is a critical step in high-dimensional classification tasks, particularly under challenging conditions of double imbalance, namely settings characterized by both class imbalance in the response variable and dimensional…

Methodology · Statistics 2025-06-13 Fabio Demaria

Swarm optimization algorithms are widely used for feature selection before data mining and machine learning applications. The metaheuristic nature-inspired feature selection approaches are used for single-objective optimization tasks,…

Artificial Intelligence · Computer Science 2021-07-30 Hritam Basak , Mayukhmali Das , Susmita Modak

Research increasingly relies on computational methods to analyze experimental data and predict molecular properties. Current approaches often require researchers to use a variety of tools for statistical analysis and machine learning,…

Quantitative Methods · Quantitative Biology 2025-12-01 Luke Rimmo Lego , Samantha Gauthier , Denver Jn. Baptiste

In recent years the importance of finding a meaningful pattern from huge datasets has become more challenging. Data miners try to adopt innovative methods to face this problem by applying feature selection methods. In this paper we propose…

Machine Learning · Computer Science 2014-03-11 Mehdi Naseriparsa , Amir-masoud Bidgoli , Touraj Varaee

One of the central goals in precision health is the understanding and interpretation of high-dimensional biological data to identify genes and markers associated with disease initiation, development, and outcomes. Though significant effort…

Quantitative Methods · Quantitative Biology 2020-09-18 Zhi Huang , Paul Salama , Wei Shao , Jie Zhang , Kun Huang