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Markov state models (MSMs) have been demonstrated to be a powerful method for computationally studying intramolecular processes such as protein folding and macromolecular conformational changes. In this article, we present a new approach to…

Biological Physics · Physics 2015-06-18 Matthew R. Perkett , Michael F. Hagan

Verifying quantum systems has attracted a lot of interest in the last decades.In this paper, we study the quantitative model-checking of quantum continuous-time Markov chains (quantum CTMCs). The branching-time properties of quantum CTMCs…

Logic in Computer Science · Computer Science 2025-11-19 Ming Xu , Jingyi Mei , Ji Guan , Yuxin Deng , Nengkun Yu

This study presents a neural network-enhanced approach to modeling disease spread dynamics over time and space. Neural networks are used to estimate time-varying parameters, with two calibration methods explored: Approximate Bayesian…

Quantitative Methods · Quantitative Biology 2024-10-29 Randy L. Caga-anan

Complex high dimensional stochastic dynamic systems arise in many applications in the natural sciences and especially biology. However, while these systems are difficult to describe analytically, "snapshot" measurements that sample the…

Machine Learning · Computer Science 2019-12-03 Scott Gigante , David van Dijk , Kevin Moon , Alexander Strzalkowski , Guy Wolf , Smita Krishnaswamy

Many scientific and engineering systems exhibit intrinsically multimodal behavior arising from latent regime switching and non-unique physical mechanisms. In such settings, learning the full conditional distribution of admissible outcomes…

Machine Learning · Computer Science 2026-02-12 Jinkyo Han , Bahador Bahmani

The time-changing nature of our world demands processing of huge amounts of information in fast and reliable way to generate successful behaviors. Therefore, significant brain resources are devoted to process spatiotemporal information.…

Dynamic graph representation learning plays a crucial role in understanding evolving behaviors. However, existing methods often struggle with flexibility, adaptability, and the preservation of temporal and structural dynamics. To address…

Machine Learning · Computer Science 2025-01-22 He Yu , Jing Liu

When analysing gene expression time series data an often overlooked but crucial aspect of the model is that the regulatory network structure may change over time. Whilst some approaches have addressed this problem previously in the…

Molecular Networks · Quantitative Biology 2012-03-05 Thomas Thorne , Michael P. H Stumpf

Networks observed in real world like social networks, collaboration networks etc., exhibit temporal dynamics, i.e. nodes and edges appear and/or disappear over time. In this paper, we propose a generative, latent space based, statistical…

Social and Information Networks · Computer Science 2018-11-08 Shubham Gupta , Gaurav Sharma , Ambedkar Dukkipati

Complex networks, comprised of individual elements that interact with each other through reaction channels, are ubiquitous across many scientific and engineering disciplines. Examples include biochemical, pharmacokinetic, epidemiological,…

Mathematical Physics · Physics 2013-06-14 John Goutsias , Garrett Jenkinson

Queueing networks are notoriously difficult to analyze sans both Markovian and stationarity assumptions. Much of the theoretical contribution towards performance analysis of time-inhomogeneous single class queueing networks has focused on…

Probability · Mathematics 2017-08-22 Harsha Honnappa , Rahul Jain

Markov chains have been widely employed as a fundamental model in the studies of probabilistic and stochastic communicating and concurrent systems. It is well-understood that decomposition techniques play a key role in reachability analysis…

Quantum Physics · Physics 2018-02-15 Ji Guan , Yuan Feng , Mingsheng Ying

Stochastic processes find applications in modelling systems in a variety of disciplines. A large number of stochastic models considered are Markovian in nature. It is often observed that higher order Markov processes can model the data…

Probability · Mathematics 2021-04-13 Suryadeepto Nag

Temporal networks of face-to-face interactions between individuals are useful proxies of the dynamics of social systems on fast time scales. Several empirical statistical properties of these networks have been shown to be robust across a…

Physics and Society · Physics 2023-02-03 Didier Le Bail , Mathieu Génois , Alain Barrat

This work aims at providing a new model for time series classification based on learning from just one example. We assume that time series can be well characterized as a parametric random process, a sort of Hidden semi-Markov Model…

Machine Learning · Statistics 2022-11-18 Adrián Pérez Herrero , Paulo Félix Lamas , Jesús María Rodríguez Presedo

Dynamic networks are used in a variety of fields to represent the structure and evolution of the relationships between entities. We present a model which embeds longitudinal network data as trajectories in a latent Euclidean space. A Markov…

Methodology · Statistics 2020-05-19 Daniel K. Sewell , Yuguo Chen

The stochastic trajectories of molecules in living cells, as well as the dynamics in many other complex systems, often exhibit memory in their path over long periods of time. In addition, these systems can show dynamic heterogeneities due…

Statistical Mechanics · Physics 2024-07-10 Michał Balcerek , Agnieszka Wyłomańska , Krzysztof Burnecki , Ralf Metzler , Diego Krapf

Multi-state models are frequently applied for representing processes evolving through a discrete set of state. Important classes of multi-state models arise when transitions between states may depend on the time since entry into the current…

Methodology · Statistics 2022-02-28 Rosario Barone , Andrea Tancredi

As a relatively new field, network neuroscience has tended to focus on aggregate behaviours of the brain averaged over many successive experiments or over long recordings in order to construct robust brain models. These models are limited…

Neurons and Cognition · Quantitative Biology 2022-05-19 James Wilsenach , Katie Warnaby , Charlotte M. Deane , Gesine Reinert

Markov models of character substitution on phylogenies form the foundation of phylogenetic inference frameworks. Early models made the simplifying assumption that the substitution process is homogeneous over time and across sites in the…

Populations and Evolution · Quantitative Biology 2019-06-13 Guy Baele , Mandev S. Gill , Philippe Lemey , Marc A. Suchard