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Normative and task-driven theories offer powerful top-down explanations for biological systems, yet the goals of quantitatively arbitrating between competing theories, and utilizing them as inductive biases to improve data-driven fits of…

Artificial Intelligence · Computer Science 2025-09-30 Bahti Zakirov , Gašper Tkačik

In this technical note, we address an unresolved challenge in neuroimaging statistics: how to determine which of several datasets is the best for inferring neuronal responses. Comparisons of this kind are important for experimenters when…

In the emotion regulation literature, the amount of neuroimaging studies on cognitive reappraisal led the impression that the same top-down, control-related neural mechanisms characterize all emotion regulation strategies. However, top-down…

Neurons and Cognition · Quantitative Biology 2023-05-26 Bianca Monachesi , Alessandro Grecucci , Parisa Ahmadi Ghomroudi , Irene Messina

In a meta-analysis, it is important to specify a model that adequately describes the effect-size distribution of the underlying population of studies. The conventional normal fixed-effect and normal random-effects models assume a normal…

Methodology · Statistics 2013-10-21 George Karabatsos , Elizabeth Talbott , Stephen G. Walker

Analyzing data from multiple neuroimaging studies has great potential in terms of increasing statistical power, enabling detection of effects of smaller magnitude than would be possible when analyzing each study separately and also allowing…

In supervised learning, the output variable to be predicted is often represented as a function, such as a spectrum or probability distribution. Despite its importance, functional output regression remains relatively unexplored. In this…

Machine Learning · Statistics 2025-03-19 Minoru Kusaba , Megumi Iwayama , Ryo Yoshida

Recent advances have shown promise in emotion recognition from electroencephalogram (EEG) signals by employing bi-hemispheric neural architectures that incorporate neuroscientific priors into deep learning models. However, interpretability…

Resting-state brain functional connectivity quantifies the synchrony between activity patterns of different brain regions. In functional magnetic resonance imaging (fMRI), each region comprises a set of spatially contiguous voxels at which…

Methodology · Statistics 2025-11-07 Ruobin Liu , Chao Zhang , Chau Tran , Sophie Achard , Wendy Meiring , Alexander Petersen

Understanding how emotional expression in language relates to brain function is a challenge in computational neuroscience and affective computing. Traditional neuroimaging is costly and lab-bound, but abundant digital text offers new…

Computation and Language · Computer Science 2025-12-23 Gideon Vos , Maryam Ebrahimpour , Liza van Eijk , Zoltan Sarnyai , Mostafa Rahimi Azghadi

Functional magnetic resonance imaging or functional MRI (fMRI) is a non-invasive way to assess brain activity by detecting changes associated with blood flow. In this work, we propose a full Bayesian procedure to analyze fMRI data for…

In neuroimaging studies, it becomes increasingly important to study associations between different imaging modalities using image-on-image regression (IIR), which faces challenges in interpretation, statistical inference, and prediction.…

Applications · Statistics 2026-03-24 Guoxuan Ma , Bangyao Zhao , Hasan Abu-Amara , Jian Kang

Longitudinal imaging studies are essential to understanding the neural development of neuropsychiatric disorders, substance use disorders, and the normal brain. The main objective of this paper is to develop a two-stage adjusted…

Applications · Statistics 2011-08-12 Xiaoyan Shi , Joseph G. Ibrahim , Jeffrey Lieberman , Martin Styner , Yimei Li , Hongtu Zhu

Replicated network data are increasingly available in many research fields. In connectomic applications, inter-connections among brain regions are collected for each patient under study, motivating statistical models which can flexibly…

Methodology · Statistics 2018-09-11 Daniele Durante , David B. Dunson , Joshua T. Vogelstein

Although Gaussian processes (GPs) with deep kernels have been successfully used for meta-learning in regression tasks, its uncertainty estimation performance can be poor. We propose a meta-learning method for calibrating deep kernel GPs for…

Machine Learning · Statistics 2023-12-14 Tomoharu Iwata , Atsutoshi Kumagai

Multimodal imaging has transformed neuroscience research. While it presents unprecedented opportunities, it also imposes serious challenges. Particularly, it is difficult to combine the merits of the interpretability attributed to a simple…

Methodology · Statistics 2021-11-25 Xiaowu Dai , Lexin Li

We propose a general nonparametric Bayesian framework for binary regression, which is built from modeling for the joint response-covariate distribution. The observed binary responses are assumed to arise from underlying continuous random…

Methodology · Statistics 2016-09-06 Maria DeYoreo , Athanasios Kottas

Task functional magnetic resonance imaging (fMRI) is a type of neuroimaging data used to identify areas of the brain that activate during specific tasks or stimuli. These data are conventionally modeled using a massive univariate approach…

Methodology · Statistics 2022-11-04 Daniel A. Spencer , David Bolin , Amanda F. Mejia

Multi-subject functional magnetic resonance imaging (fMRI) data has been increasingly used to study the population-wide relationship between human brain activity and individual biological or behavioral traits. A common method is to regress…

Applications · Statistics 2015-09-15 Fan Li , Tingting Zhang , Quanli Wang , Marlen Z. Gonzalez , Erin L. Maresh , James A. Coan

Doubly stochastic Poisson processes, also known as the Cox processes, frequently occur in various scientific fields. In this article, motivated primarily by analyzing Cox process data in biophysics, we propose a nonparametric kernel-based…

Applications · Statistics 2011-01-07 Tingting Zhang , S. C. Kou

Cluster-level inference procedures are widely used for brain mapping. These methods compare the size of clusters obtained by thresholding brain maps to an upper bound under the global null hypothesis, computed using Random Field Theory or…

Methodology · Statistics 2022-07-27 Alexandre Blain , Bertrand Thirion , Pierre Neuvial