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Ecological Momentary Assessments (EMA) capture real-time thoughts and behaviors in natural settings, producing rich longitudinal data for statistical and physiological analyses. However, the robustness of these analyses can be compromised…

Methodology · Statistics 2023-11-21 Yiheng Wei , Donald Hedeker

Missing data are ubiquitous in empirical databases, yet statistical analyses typically require complete data matrices. Multiple imputation offers a principled solution for filling these gaps. This study evaluates the performance of several…

Computation · Statistics 2026-02-05 Enzo Porto Brasil

Missing values in tabular data restrict the use and performance of machine learning, requiring the imputation of missing values. The most popular imputation algorithm is arguably multiple imputations using chains of equations (MICE), which…

Machine Learning · Computer Science 2022-03-01 Manar D Samad , Sakib Abrar , Norou Diawara

This work is motivated by the needs of predictive analytics on healthcare data as represented by Electronic Medical Records. Such data is invariably problematic: noisy, with missing entries, with imbalance in classes of interests, leading…

Machine Learning · Statistics 2016-09-28 Talayeh Razzaghi , Oleg Roderick , Ilya Safro , Nicholas Marko

Missing data remains a very common problem in large datasets, including survey and census data containing many ordinal responses, such as political polls and opinion surveys. Multiple imputation (MI) is usually the go-to approach for…

Methodology · Statistics 2024-12-25 Chayut Wongkamthong , Olanrewaju Akande

In longitudinal data a response variable is measured over time, or under different conditions, for a cohort of individuals. In many situations all intended measurements are not available which results in missing values. If the missing value…

Methodology · Statistics 2022-08-10 Ahmed M. Gad , Nesma M. Darwish

Imputation of missing attribute values in medical datasets for extracting hidden knowledge from medical datasets is an interesting research topic of interest which is very challenging. One cannot eliminate missing values in medical records.…

Databases · Computer Science 2016-03-11 Yelipe UshaRani , P. Sammulal

In medical domain, data features often contain missing values. This can create serious bias in the predictive modeling. Typical standard data mining methods often produce poor performance measures. In this paper, we propose a new method to…

Machine Learning · Statistics 2015-03-24 Talayeh Razzaghi , Oleg Roderick , Ilya Safro , Nick Marko

Multiple imputation (MI) is a popular method for dealing with missing values. One main advantage of MI is to separate the imputation phase and the analysis one. However, both are related since they are based on distribution assumptions that…

Methodology · Statistics 2021-06-09 Vincent Audigier , Ndèye Niang , Matthieu Resche-Rigon

The time series cluster kernel (TCK) provides a powerful tool for analysing multivariate time series subject to missing data. TCK is designed using an ensemble learning approach in which Bayesian mixture models form the base models. Because…

Machine Learning · Computer Science 2019-07-12 Karl Øyvind Mikalsen , Cristina Soguero-Ruiz , Filippo Maria Bianchi , Arthur Revhaug , Robert Jenssen

Three-level data structures arising from repeated measures on individuals clustered within larger units are common in health research studies. Missing data are prominent in such studies and are often handled via multiple imputation (MI).…

Clinical decision support using data mining techniques offers more intelligent way to reduce the decision error in the last few years. However, clinical datasets often suffer from high missingness, which adversely impacts the quality of…

Machine Learning · Computer Science 2020-11-20 Xuetong Wu , Hadi Akbarzadeh Khorshidi , Uwe Aickelin , Zobaida Edib , Michelle Peate

Joint modeling technique is a recent advancement in effectively analyzing the longitudinal history of patients with the occurrence of an event of interest attached to it. This procedure is successfully implemented in biomarker studies to…

Methodology · Statistics 2021-01-08 Gajendra K. Vishwakarma , Atanu Bhattacharjee , Souvik Banerjee

There has been an increasing interest in using cell and gene therapy (CGT) to treat/cure difficult diseases. The hallmark of CGT trials are the small sample size and extremely high efficacy. Due to the innovation and novelty of such…

Applications · Statistics 2025-10-23 Yaoyuan Vincent Tan , Gang Xu , Chenkun Wang

Routinely collected nation-wide registers contain socio-economic and health-related information from a large number of individuals. However, important information on lifestyle, biological and other risk factors is available at most for…

Methodology · Statistics 2024-09-23 Tommi Härkänen , Sangita Kulathinal , Arya Panthalanickal Vijayakumar

Cluster-randomized trials (CRTs) on fragile populations frequently encounter complex attrition problems where the reasons for missing outcomes can be heterogeneous, with participants who are known alive, known to have died, or with unknown…

Methodology · Statistics 2025-05-06 Guangyu Tong , Chenxi Li , Eric Velazquez , Michael O. Harhay , Fan Li

Case-cohort studies are conducted within cohort studies, wherein collection of exposure data is limited to a subset of the cohort, leading to a large proportion of missing data by design. Standard analysis uses inverse probability weighting…

Cluster randomized trials (CRTs) often enroll large numbers of participants, but due to logistical and fiscal challenges, only a subset of participants may be selected for measurement of certain outcomes, and those sampled may, purposely or…

Integrative analysis of datasets generated by multiple cohorts is a widely-used approach for increasing sample size, precision of population estimators, and generalizability of analysis results in epidemiological studies. However, often…

The use of flexible machine-learning (ML) models to generate imputations of missing data within the framework of Multiple Imputation (MI) has recently gained traction, particularly in observational settings. For randomised controlled trials…

Methodology · Statistics 2025-10-07 Mia S. Tackney , Jonathan W. Bartlett , Elizabeth Williamson , Kim May Lee