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We present a cascade deep neural network to segment retinal vessels in volumetric optical coherence tomography (OCT). Two types of knowledge are infused into the network for confining the searching regions. (1) Histology. The retinal…

Image and Video Processing · Electrical Eng. & Systems 2019-10-22 Liyang Fang , Jianlong Yang , Lei Mou , Huihong Zhang , Zhenjie Chai , Zhi Chen , Jiang Liu

We address the challenge of automated classification of diffuse large B-cell lymphoma (DLBCL) into its two primary subtypes: activated B-cell-like (ABC) and germinal center B-cell-like (GCB). Accurate classification between these subtypes…

Computer Vision and Pattern Recognition · Computer Science 2024-11-14 Ravi Kant Gupta , Mohit Jindal , Garima Jain , Epari Sridhar , Subhash Yadav , Hasmukh Jain , Tanuja Shet , Uma Sakhdeo , Manju Sengar , Lingaraj Nayak , Bhausaheb Bagal , Umesh Apkare , Amit Sethi

Objective: To validate and compare the performance of eight available deep learning architectures in grading the severity of glaucoma based on color fundus images. Materials and Methods: We retrospectively collected a dataset of 5978 fundus…

Computer Vision and Pattern Recognition · Computer Science 2018-11-01 Yi Zhen , Lei Wang , Han Liu , Jian Zhang , Jiantao Pu

We have analyzed the deep Chandra observation (~155 ks) of the Compton Thick Active Galactic Nucleus (CT AGN) ESO 428-G014, to study in detail the morphology of the diffuse X-ray emission in the inner ~500 pc radius region. Comparing…

High Energy Astrophysical Phenomena · Physics 2018-10-10 G. Fabbiano , A. Paggi , M. Karovska , M. Elvis , W. P. Maksym , Junfeng Wang

Accurate segmentation of retinal vessels is crucial for the clinical diagnosis of numerous ophthalmic and systemic diseases. However, traditional Convolutional Neural Network (CNN) methods exhibit inherent limitations, struggling to capture…

Computer Vision and Pattern Recognition · Computer Science 2025-12-02 Hongyu Xu , Panpan Meng , Meng Wang , Dayu Hu , Liming Liang , Xiaoqi Sheng

Deep Anterior Lamellar Keratoplasty (DALK) is a partial-thickness corneal transplant procedure used to treat corneal stromal diseases. A crucial step in this procedure is the precise separation of the deep stroma from Descemet's membrane…

Image and Video Processing · Electrical Eng. & Systems 2025-01-10 J. Yu , H. Yi , Y. Wang , J. D. Opfermann , W. G. Gensheimer , A. Krieger , J. U. Kang

Purpose: The purpose of the present article is to propose a modified version of the D-shaped collimator used at the Univ. Hosp. of Essen for retinoblastoma treatment that reduces even further the irradiation field with the scope to reduce…

Medical Physics · Physics 2018-09-26 P. A. Mayorga , L. Brualla , W. Sauerwein , A. M. Lallena

Optic disc (OD) and optic cup (OC) are regions of prominent clinical interest in a retinal fundus image. They are the primary indicators of a glaucomatous condition. With the advent and success of deep learning for healthcare research,…

Image and Video Processing · Electrical Eng. & Systems 2020-12-15 Aniketh Manjunath , Subramanya Jois , Chandra Sekhar Seelamantula

Tuberculosis (TB) is a top-10 cause of death worldwide. Though the WHO recommends chest radiographs (CXRs) for TB screening, the limited availability of CXR interpretation is a barrier. We trained a deep learning system (DLS) to detect…

High fidelity segmentation of both macro and microvascular structure of the retina plays a pivotal role in determining degenerative retinal diseases, yet it is a difficult problem. Due to successive resolution loss in the encoding phase…

Image and Video Processing · Electrical Eng. & Systems 2021-10-20 Sharif Amit Kamran , Khondker Fariha Hossain , Alireza Tavakkoli , Stewart Lee Zuckerbrod , Kenton M. Sanders , Salah A. Baker

Patients with long-standing diabetes often fall prey to Diabetic Retinopathy (DR) resulting in changes in the retina of the human eye, which may lead to loss of vision in extreme cases. The aim of this study is two-fold: (a) create deep…

Image and Video Processing · Electrical Eng. & Systems 2021-08-17 Shaswat Patel , Maithili Lohakare , Samyak Prajapati , Shaanya Singh , Nancy Patel

The repointing time of the XRT instrument on the Neil Gehrels Swift Observatory satellite has posed challenges in observing and studying the early X-ray emissions within $\approx40$ s after a gamma-ray burst (GRB) trigger. To address this…

High Energy Astrophysical Phenomena · Physics 2024-05-10 C. L. Bianco , M. T. Mirtorabi , R. Moradi , F. Rastegarnia , J. A. Rueda , R. Ruffini , Y. Wang , M. Della Valle , Liang Li , S. R. Zhang

The study of dark matter substructure through strong gravitational lensing has shown enormous promise in probing the properties of dark matter on sub-galactic scales. This approach has already been used to place strong constraints on a wide…

Astrophysics of Galaxies · Physics 2025-03-14 Charles Gannon , Anna Nierenberg , Andrew Benson , Ryan Keeley , Xiaolong Du , Daniel Gilman

We analyze the effect of screening provided by the additional graphene layer in double layer graphene heterostructures (DLGs) on transport characteristics of DLG devices in the metallic regime. The effect of gate-tunable charge density in…

Mesoscale and Nanoscale Physics · Physics 2012-11-16 K. Kechedzhi , E. H. Hwang , S. Das Sarma

In this paper we present a label-free, stable and highly sensitive fiber-optic sensor for detection of environmental toxin microcystin-LR (MC-LR). Thiolated MC-LR-targeting aptamer covalently immobilized on dual-resonance long-period fiber…

Retinopathy of Prematurity (ROP) is an eye disorder primarily affecting premature infants with lower weights. It causes proliferation of vessels in the retina and could result in vision loss and, eventually, retinal detachment, leading to…

Image and Video Processing · Electrical Eng. & Systems 2020-04-06 Alexander Ding , Qilei Chen , Yu Cao , Benyuan Liu

Precis: A hybrid deep-learning model combines NFL reflectance and other OCT parameters to improve glaucoma diagnosis. Objective: To investigate if a deep learning model could be used to combine nerve fiber layer (NFL) reflectance and other…

Image and Video Processing · Electrical Eng. & Systems 2024-06-07 Ou Tan , David S. Greenfield , Brian A. Francis , Rohit Varma , Joel S. Schuman , David Huang , Dongseok Choi

Objective: Glaucoma is the second leading cause of blindness worldwide. Glaucomatous progression can be easily monitored by analyzing the degeneration of retinal ganglion cells (RGCs). Many researchers have screened glaucoma by measuring…

Image and Video Processing · Electrical Eng. & Systems 2020-11-22 Hina Raja , Taimur Hassan , Muhammad Usman Akram , Naoufel Werghi

A standard dose of radioactive tracer must be delivered into the patients body to obtain high-quality Positron Emission Tomography (PET) images for diagnostic purposes, which raises the risk of radiation harm. A reduced tracer dose, on the…

We employ a number of statistical measures to characterize neural discharge activity in cat retinal ganglion cells (RGCs) and in their target lateral geniculate nucleus (LGN) neurons under various stimulus conditions, and we develop a new…

Biological Physics · Physics 2007-05-23 Steven B. Lowen , Tsuyoshi Ozaki , Ehud Kaplan , Bahaa E. A. Saleh , Malvin C. Teich