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We review a recent trend in computational systems biology which aims at using pattern recognition algorithms to infer the structure of large-scale biological networks from heterogeneous genomic data. We present several strategies that have…

Quantitative Methods · Quantitative Biology 2008-09-22 Jean-Philippe Vert

Dependency trees help relation extraction models capture long-range relations between words. However, existing dependency-based models either neglect crucial information (e.g., negation) by pruning the dependency trees too aggressively, or…

Computation and Language · Computer Science 2018-09-28 Yuhao Zhang , Peng Qi , Christopher D. Manning

We obtain structure theorems for graphs excluding a fan (a path with a universal vertex) or a dipole ($K_{2,k}$) as a topological minor. The corresponding decompositions can be computed in FPT linear time. This is motivated by the study of…

Discrete Mathematics · Computer Science 2025-02-18 Hugo Jacob , William Lochet , Christophe Paul

Parameterized algorithms are a way to solve hard problems more efficiently, given that a specific parameter of the input is small. In this paper, we apply this idea to the field of answer set programming (ASP). To this end, we propose two…

Logic in Computer Science · Computer Science 2017-02-10 Johannes Fichte , Markus Hecher , Michael Morak , Stefan Woltran

Low rank approximation of matrices has been well studied in literature. Singular value decomposition, QR decomposition with column pivoting, rank revealing QR factorization (RRQR), Interpolative decomposition etc are classical deterministic…

Numerical Analysis · Mathematics 2016-06-22 N. Kishore Kumar , Jan Shneider

We introduce structured decompositions, category-theoretic structures which simultaneously generalize notions from graph theory (including treewidth, layered treewidth, co-treewidth, graph decomposition width, tree independence number,…

Category Theory · Mathematics 2025-05-21 Benjamin Merlin Bumpus , Zoltan A. Kocsis , Jade Edenstar Master , Emilio Minichiello

The supertree construction problem is about combining several phylogenetic trees with possibly conflicting information into a single tree that has all the leaves of the source trees as its leaves and the relationships between the leaves are…

Computational Engineering, Finance, and Science · Computer Science 2020-02-19 Laura Koponen , Emilia Oikarinen , Tomi Janhunen , Laura Säilä

We study the interplay between surrogate methods for structured prediction and techniques from multitask learning designed to leverage relationships between surrogate outputs. We propose an efficient algorithm based on trace norm…

Machine Learning · Computer Science 2019-03-05 Giulia Luise , Dimitris Stamos , Massimiliano Pontil , Carlo Ciliberto

The alignment between RNA sequences and structures in foundation models (FMs) has yet to be thoroughly investigated. Existing FMs have struggled to establish sequence-structure alignment, hindering the free flow of genomic information…

Genomics · Quantitative Biology 2024-12-16 Heng Yang , Renzhi Chen , Ke Li

Tree kernels are fundamental tools that have been leveraged in many applications, particularly those based on machine learning for Natural Language Processing tasks. In this paper, we devise a parallel implementation of the sequential…

Computation and Language · Computer Science 2023-05-16 Souad Taouti , Hadda Cherroun , Djelloul Ziadi

Protein structure prediction can be shown to be an NP-hard problem; the number of conformations grows exponentially with the number of residues. The native conformations of proteins occupy a very small subset of these, hence an exploratory,…

Chemical Physics · Physics 2008-02-03 Mehul M. Khimasia , Peter V. Coveney

Compound graphs are networks in which vertices can be grouped into larger subsets, with these subsets capable of further grouping, resulting in a nesting that can be many levels deep. In several applications, including biological workflows,…

Human-Computer Interaction · Computer Science 2024-08-09 Chang Han , Justin Lieffers , Clayton Morrison , Katherine E. Isaacs

Deep neural networks have recently achieved state of the art performance thanks to new training algorithms for rapid parameter estimation and new regularization methods to reduce overfitting. However, in practice the network architecture…

Machine Learning · Computer Science 2016-03-04 Minyoung Kim , Luca Rigazio

Networks play a prominent role in the study of complex systems of interacting entities in biology, sociology, and economics. Despite this diversity, we demonstrate here that a statistical model decomposing networks into matching and…

Physics and Society · Physics 2016-02-05 Rudolf P. Rohr , Russel E. Naisbit , Christian Mazza , Louix-Félix Bersier

New applications of data mining, such as in biology, bioinformatics, or sociology, are faced with large datasetsstructured as graphs. We introduce a novel class of tree-shapedpatterns called tree queries, and present algorithms for…

Databases · Computer Science 2010-08-17 Eveline Hoekx , Jan Van den Bussche

Our work is concerned with the generation and targeted design of RNA, a type of genetic macromolecule that can adopt complex structures which influence their cellular activities and functions. The design of large scale and complex…

Biomolecules · Quantitative Biology 2021-02-02 Zichao Yan , William L. Hamilton , Mathieu Blanchette

In this work, we consider the Combinatorial RNA Design problem, a minimal instance of the RNA design problem which aims at finding a sequence that admits a given target as its unique base pair maximizing structure. We provide complete…

Quantitative Methods · Quantitative Biology 2015-06-22 Jozef Haleš , Ján Maňuch , Yann Ponty , Ladislav Stacho

In this paper, we propose an end-to-end deep learning model, called E2Efold, for RNA secondary structure prediction which can effectively take into account the inherent constraints in the problem. The key idea of E2Efold is to directly…

Machine Learning · Computer Science 2020-06-11 Xinshi Chen , Yu Li , Ramzan Umarov , Xin Gao , Le Song

Background. The supertree problem, i.e., the task of finding a common refinement of a set of rooted trees is an important topic in mathematical phylogenetics. The special case of a common leaf set $L$ is known to be solvable in linear time.…

Data Structures and Algorithms · Computer Science 2021-09-27 David Schaller , Marc Hellmuth , Peter F. Stadler

The problem of selecting a small, yet high quality subset of patterns from a larger collection of itemsets has recently attracted lot of research. Here we discuss an approach to this problem using the notion of decomposable families of…

Machine Learning · Computer Science 2020-06-18 Nikolaj Tatti , Hannes Heikinheimo