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We enumerate possible topologies of pseudoknots in single-stranded RNA molecules. We use a steepest-descent approximation in the large N matrix field theory, and a Feynman diagram formalism to describe the resulting pseudoknot structure.

Biological Physics · Physics 2013-05-29 M. Pillsbury , H. Orland , A. Zee

We consider the inverse-folding problem for RNA secondary structures: for a given (pseudo-knot-free) secondary structure find a sequence that has that structure as its ground state. If such a sequence exists, the structure is called…

Biological Physics · Physics 2015-06-26 Bernd Burghardt , Alexander K. Hartmann

Attempting to recognize a tree inside a phylogenetic network is a fundamental undertaking in evolutionary analysis. In the last few years, therefore, tree-based phylogenetic networks, which are defined by a spanning tree called a…

Combinatorics · Mathematics 2020-09-29 Momoko Hayamizu

Parameterized complexity allows us to analyze the time complexity of problems with respect to a natural parameter depending on the problem. Reoptimization looks for solutions or approximations for problem instances when given solutions to…

Computational Complexity · Computer Science 2019-07-31 Hans-Joachim Böckenhauer , Elisabet Burjons , Martin Raszyk , Peter Rossmanith

Visualization of the adjacency matrix enables us to capture macroscopic features of a network when the matrix elements are aligned properly. Community structure, a network consisting of several densely connected components, is a…

Physics and Society · Physics 2023-07-11 Masaki Ochi , Tatsuro Kawamoto

This paper presents an efficient method to perform Structured Matrix Approximation by Separation and Hierarchy (SMASH), when the original dense matrix is associated with a kernel function. Given points in a domain, a tree structure is first…

Numerical Analysis · Mathematics 2017-05-17 Difeng Cai , Edmond Chow , Yousef Saad , Yuanzhe Xi

We present a conceptually clear and algorithmically useful framework for parameterizing the costs of tensor network contraction. Our framework is completely general, applying to tensor networks with arbitrary bond dimensions, open legs, and…

Data Structures and Algorithms · Computer Science 2019-06-04 Bryan O'Gorman

Background Nucleotide sequences contain multiple codes responsible for organism's functioning and structure. They can be investigated by various signal processing methods. These techniques are well suited for indication of frequently…

Quantitative Methods · Quantitative Biology 2007-05-23 Simon Kogan

Each human genome is a 3 billion base pair set of encoding instructions. Decoding the genome using deep learning fundamentally differs from most tasks, as we do not know the full structure of the data and therefore cannot design…

Machine Learning · Computer Science 2016-05-24 Laura Deming , Sasha Targ , Nate Sauder , Diogo Almeida , Chun Jimmie Ye

Tree-structured neural networks encode a particular tree geometry for a sentence in the network design. However, these models have at best only slightly outperformed simpler sequence-based models. We hypothesize that neural sequence models…

Computation and Language · Computer Science 2015-11-10 Samuel R. Bowman , Christopher D. Manning , Christopher Potts

Analysis of the sequence-structure relationship in RNA molecules are essential to evolutionary studies but also to concrete applications such as error-correction methodologies in sequencing technologies. The prohibitive sizes of the…

Quantitative Methods · Quantitative Biology 2013-05-31 Vladimir Reinharz , Yann Ponty , Jérôme Waldispühl

Grouping elements into families to analyse them separately is a standard analysis procedure in many areas of sciences. We propose herein a new algorithm based on the simple idea that members from a family look like each other, and don't…

Computer Vision and Pattern Recognition · Computer Science 2025-03-26 Axel Descamps , Sélène Forget , Aliénor Lahlou , Claire Lavergne , Camille Berthelot , Guillaume Stirnemann , Rodolphe Vuilleumier , Nicolas Chéron

The notion of $\mathcal{H}$-treewidth, where $\mathcal{H}$ is a hereditary graph class, was recently introduced as a generalization of the treewidth of an undirected graph. Roughly speaking, a graph of $\mathcal{H}$-treewidth at most $k$…

Data Structures and Algorithms · Computer Science 2023-06-30 Bart M. P. Jansen , Jari J. H. de Kroon , Michal Wlodarczyk

The class of self-nested trees presents remarkable compression properties because of the systematic repetition of subtrees in their structure. In this paper, we provide a better combinatorial characterization of this specific family of…

Data Structures and Algorithms · Computer Science 2018-10-26 Romain Azaïs , Jean-Baptiste Durand , Christophe Godin

We study plane trees as a model for RNA secondary structure, assigning energy to each tree based on the Nearest Neighbor Thermodynamic Model, and defining a corresponding Gibbs distribution on the trees. Through a bijection between plane…

Combinatorics · Mathematics 2020-04-03 Anna Kirkpatrick , Kalen Patton

We apply a tree-based methodology to solve new, very broadly defined families of nested recursions of the general form R(n)=sum_{i=1}^k R(n-a_i-sum_{j=1}^p R(n-b_{ij})), where a_i are integers, b_{ij} are natural numbers, and k,p are…

Combinatorics · Mathematics 2018-08-09 Abraham Isgur , Vitaly Kuznetsov , Mustazee Rahman , Stephen Tanny

Many computerized methods for RNA-RNA interaction structure prediction have been developed. Recently, $O(N^6)$ time and $O(N^4)$ space dynamic programming algorithms have become available that compute the partition function of RNA-RNA…

Mathematical Physics · Physics 2010-07-15 Andrew X. Li , Manja Marz , Jing Qin , Christian M. Reidys

Deep learning has recently demonstrated its ability to rival the human brain for visual object recognition. As datasets get larger, a natural question to ask is if existing deep learning architectures can be extended to handle the 50+K…

Machine Learning · Computer Science 2020-08-04 Sumanth Chennupati , Sai Nooka , Shagan Sah , Raymond W Ptucha

Low-rank matrix approximations, such as the truncated singular value decomposition and the rank-revealing QR decomposition, play a central role in data analysis and scientific computing. This work surveys and extends recent research which…

Numerical Analysis · Mathematics 2014-04-29 Nathan Halko , Per-Gunnar Martinsson , Joel A. Tropp

A randomized algorithm for computing a data sparse representation of a given rank structured matrix $A$ (a.k.a. an $H$-matrix) is presented. The algorithm draws on the randomized singular value decomposition (RSVD), and operates under the…

Numerical Analysis · Mathematics 2024-06-25 James Levitt , Per-Gunnar Martinsson