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Treatment planning system calculations in inhomogeneous regions may present significant inaccuracies due to loss of electronic equilibrium. In this study, three different dose calculation algorithms, pencil beam, collapsed cone, and…

Medical Physics · Physics 2015-03-12 Sung Jin Kim , Dong Ho Kim , Sung Kyu Kim

Flux balance analysis has proven an effective tool for analyzing metabolic networks. In flux balance analysis, reaction rates and optimal pathways are ascertained by solving a linear program, in which the growth rate is maximized subject to…

Optimization and Control · Mathematics 2018-04-10 Amir Akbari , Paul I. Barton

Consider convex optimization problems subject to a large number of constraints. We focus on stochastic problems in which the objective takes the form of expected values and the feasible set is the intersection of a large number of convex…

Machine Learning · Statistics 2015-11-13 Mengdi Wang , Yichen Chen , Jialin Liu , Yuantao Gu

Purpose: Ferumoxytal-enhanced 5D free-running whole heart CMR provides image quality comparable to CTA, but requires hours-long reconstruction time, preventing clinical usage. This study developed a variable projection augmented Lagrangian…

The procedure of Least Square-Errors curve fitting is extensively used in many computer applications for fitting a polynomial curve of a given degree to approximate a set of data. Although various methodologies exist to carry out curve…

Distributed, Parallel, and Cluster Computing · Computer Science 2015-12-29 Poorna Banerjee Dasgupta

Efficient topology optimization based on the adaptive auxiliary reduced model reanalysis (AARMR) is proposed to improve computational efficiency and scale. In this method, a projection auxiliary reduced model (PARM) is integrated into the…

Computational Engineering, Finance, and Science · Computer Science 2023-01-04 Jichao Yin , Hu Wang , Shuhao Li , Daozhen Guo

Radiotherapy treatment planning remains a time-intensive iterative process requiring expert intervention in commercial treatment planning system (TPS). While machine learning approaches have demonstrated promise, most remain depedent on…

Classically, a mainstream approach for solving a convex-concave min-max problem is to instead solve the variational inequality problem arising from its first-order optimality conditions. Is it possible to solve min-max problems faster by…

Optimization and Control · Mathematics 2025-11-06 Henry Shugart , Jason M. Altschuler

This paper presents a novel meta algorithm, Partition-Merge (PM), which takes existing centralized algorithms for graph computation and makes them distributed and faster. In a nutshell, PM divides the graph into small subgraphs using our…

Data Structures and Algorithms · Computer Science 2013-09-25 Vincent Blondel , Kyomin Jung , Pushmeet Kohli , Devavrat Shah

Purpose: We propose a general framework for quantifying predictive uncertainties of dose-related quantities and leveraging this information in a dose mimicking problem in the context of automated radiation therapy treatment planning.…

Medical Physics · Physics 2021-09-08 Tianfang Zhang , Rasmus Bokrantz , Jimmy Olsson

We conduct a theoretical study of various solution methods for the adaptive fractionation problem. The two messages of this paper are: (i) dynamic programming (DP) is a useful framework for adaptive radiation therapy, particularly adaptive…

Medical Physics · Physics 2012-02-16 Jagdish Ramakrishnan , David Craft , Thomas Bortfeld , John N. Tsitsiklis

Cardiac magnetic resonance imaging improves on diagnosis of cardiovascular diseases by providing images at high spatiotemporal resolution. Manual evaluation of these time-series, however, is expensive and prone to biased and…

Computer Vision and Pattern Recognition · Computer Science 2018-04-06 Fabian Isensee , Paul Jaeger , Peter M. Full , Ivo Wolf , Sandy Engelhardt , Klaus H. Maier-Hein

Among the new techniques of Versatile Video Coding (VVC), the quadtree with nested multi-type tree (QT+MTT) block structure yields significant coding gains by providing more flexible block partitioning patterns. However, the recursive…

Image and Video Processing · Electrical Eng. & Systems 2025-07-16 Xinmin Feng , Zhuoyuan Li , Li Li , Dong Liu , Feng Wu

In cardiac magnetic resonance (CMR) imaging, a 3D high-resolution segmentation of the heart is essential for detailed description of its anatomical structures. However, due to the limit of acquisition duration and respiratory/cardiac…

Image and Video Processing · Electrical Eng. & Systems 2021-07-09 Shuo Wang , Chen Qin , Nicolo Savioli , Chen Chen , Declan O'Regan , Stuart Cook , Yike Guo , Daniel Rueckert , Wenjia Bai

Estimating the impact of trauma treatment protocols is complicated by the high dimensional yet finite sample nature of trauma data collected from observational studies. Viscoelastic assays are highly predictive measures of hemostasis.…

Applications · Statistics 2022-09-27 Linqing Wei , Lucy Z. Kornblith , Alan Hubbard

We present a fast algorithm for generating Laguerre diagrams with cells of given volumes, which can be used for creating RVEs of polycrystalline materials for computational homogenisation, or for fitting Laguerre diagrams to EBSD or XRD…

Optimization and Control · Mathematics 2020-07-01 D. P. Bourne , P. J. J. Kok , S. M. Roper , W. D. T. Spanjer

Adaptive radiation therapy (ART) seeks to maintain accurate dose delivery by monitoring anatomical changes during treatment and modifying plans accordingly, yet commonly used approaches for estimating cumulative dose rely on heuristic,…

Medical Physics · Physics 2026-03-03 Robert Boyd , Wolfgang A. Tomé

Uncompressed clinical data from modern positron emission tomography (PET) scanners are very large, exceeding 350 million data points (projection bins). The last decades have seen tremendous advancements in mathematical imaging tools many of…

Medical Physics · Physics 2020-01-08 Matthias J. Ehrhardt , Pawel Markiewicz , Carola-Bibiane Schönlieb

Intensity-modulated proton therapy (IMPT) offers superior dose conformity with reduced exposure to surrounding healthy tissues compared to conventional photon therapy. Improving IMPT delivery efficiency reduces motion-related uncertainties,…

Medical Physics · Physics 2025-04-15 Ya-Nan Zhu , Nimita Shinde , Bowen Lin , Hao Gao

Modern data science relies on data analytic pipelines to organize interdependent computational steps. Such analytic pipelines often involve different algorithms across multiple steps, each with its own hyperparameters. To achieve the best…

Machine Learning · Computer Science 2016-06-27 Yuyu Zhang , Mohammad Taha Bahadori , Hang Su , Jimeng Sun
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