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Enhanced sampling methods such as metadynamics and umbrella sampling have become essential tools for exploring the configuration space of molecules and materials. At the same time, they have long faced a number of issues such as the…

Chemical Physics · Physics 2021-12-28 Dongdong Wang , Yanze Wang , Junhan Chang , Linfeng Zhang , Han Wang , Weinan E

Free energy calculations based on atomistic Hamiltonians and sampling are key to a first principles understanding of biomolecular processes, material properties, and macromolecular chemistry. Here, we generalize the Free Energy Perturbation…

Computational Physics · Physics 2023-07-19 Martin Reinhardt , Helmut Grubmüller

Coordinated multi-arm manipulation requires satisfying multiple simultaneous geometric constraints across high-dimensional configuration spaces, which poses a significant challenge for traditional planning and control methods. In this work,…

Robotics · Computer Science 2026-02-26 Haolei Tong , Yuezhe Zhang , Sophie Lueth , Georgia Chalvatzaki

Metasurfaces are ultrathin, engineered materials composed of nanostructures that manipulate light in ways unattainable by natural materials. Recent advances have leveraged computational optimization, machine learning, and deep learning to…

Optics · Physics 2025-08-08 Hao Li , Andrey Bogdanov

Sampling the phase space of molecular systems -- and, more generally, of complex systems effectively modeled by stochastic differential equations -- is a crucial modeling step in many fields, from protein folding to materials discovery.…

Machine Learning · Computer Science 2023-12-12 Ellis R. Crabtree , Juan M. Bello-Rivas , Andrew L. Ferguson , Ioannis G. Kevrekidis

A new gradient-based adaptive sampling method is proposed for design of experiments applications which balances space filling, local refinement, and error minimization objectives while reducing reliance on delicate tuning parameters. High…

Methodology · Statistics 2024-05-09 Lucas Caparini , Gwynn J. Elfring , Mauricio Ponga

Generative Flow Networks (GFlowNets) are a class of generative models that sample objects in proportion to a specified reward function through a learned policy. They can be trained either on-policy or off-policy, needing a balance between…

Machine Learning · Computer Science 2025-03-04 Dominic Phillips , Flaviu Cipcigan

Spatial process models are widely used for modeling point-referenced variables arising from diverse scientific domains. Analyzing the resulting random surface provides deeper insights into the nature of latent dependence within the studied…

Methodology · Statistics 2023-02-15 Aritra Halder , Sudipto Banerjee , Dipak K. Dey

We revisit the replica method for analyzing inference and learning in parametric models, considering situations where the data-generating distribution is unknown or analytically intractable. Instead of assuming idealized distributions to…

Disordered Systems and Neural Networks · Physics 2025-11-17 Takashi Takahashi

The Hamiltonian dynamics of a compressible inviscid fluid is formulated as a gauge theory. The idea of gauge equivalence is exploited to unify the study of apparantly distinct physical problems and solutions of new models can be generated…

High Energy Physics - Theory · Physics 2007-05-23 Subir Ghosh

It is now known that an extended Gaussian process model equipped with rescaling can adapt to different smoothness levels of a function valued parameter in many nonparametric Bayesian analyses, offering a posterior convergence rate that is…

Statistics Theory · Mathematics 2011-12-06 Surya T. Tokdar

Out-of-distribution (OOD) 3D relighting requires novel view synthesis under unseen lighting conditions that differ significantly from the observed images. Existing relighting methods, which assume consistent light source distributions…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Yumeng He , Yunbo Wang , Xiaokang Yang

We study the dissociative adsorption of methane at the surface of graphene. Free energy profiles, which include activation energies for different steps of the reaction, are computed from constrained ab initio molecular dynamics. At 300 K,…

Materials Science · Physics 2018-04-04 Mateusz Wlazło , Jacek A. Majewski

A parametric adaptive physics-informed greedy Latent Space Dynamics Identification (gLaSDI) method is proposed for accurate, efficient, and robust data-driven reduced-order modeling of high-dimensional nonlinear dynamical systems. In the…

Systems and Control · Electrical Eng. & Systems 2023-07-19 Xiaolong He , Youngsoo Choi , William D. Fries , Jon Belof , Jiun-Shyan Chen

A family of fast sampling methods is introduced here for molecular simulations of systems having rugged free energy landscapes. The methods represent a generalization of a strategy consisting of adjusting a model for the free energy as a…

Computational Physics · Physics 2022-02-07 Pablo F. Zubieta Rico , Juan J. de Pablo

The usual renormalization procedure for the variational approximation with a trial Gaussian ansatz for the $\lap$ model in 3+1 dimensions is re-analysed as a departing framework for the investigation of the parameters of the model. The…

High Energy Physics - Phenomenology · Physics 2015-07-03 Fabio L. Braghin

We present a differentiable formalism for learning free energies that is capable of capturing arbitrarily complex model dependencies on coarse-grained coordinates and finite-temperature response to variation of general system parameters.…

Computational Physics · Physics 2024-05-31 Blake R. Duschatko , Xiang Fu , Cameron Owen , Yu Xie , Albert Musaelian , Tommi Jaakkola , Boris Kozinsky

A model hierarchy that is based on the one-dimensional isothermal Euler equations of fluid dynamics is used for the simulation and optimisation of gas flow through a pipeline network. Adaptive refinement strategies have the aim of bringing…

Numerical Analysis · Mathematics 2017-02-01 Pia Domschke , Aseem Dua , Jeroen J. Stolwijk , Jens Lang , Volker Mehrmann

We present a consensus-based framework that unifies phase space exploration with posterior-residual-based adaptive sampling for surrogate construction in high-dimensional energy landscapes. Unlike standard approximation tasks where sampling…

Computational Physics · Physics 2025-06-03 Liyao Lyu , Huan Lei

Metamaterials provide exceptional control over physical phenomena, enabling many disruptive technologies. However, researches in hydrodynamic meta-devices have mainly used intrusive methods to manipulate material structures, limited by…

Fluid Dynamics · Physics 2025-10-01 Chen-Long Wu , Bin Wang , Hao Wang , Neng-Zhi Yao , Liujun Xu , Xuesheng Wang , Jiping Huang