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Related papers: Privacy-Preserving Data Sharing for Genome-Wide As…

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The protection of privacy of individual-level information in genome-wide association study (GWAS) databases has been a major concern of researchers following the publication of "an attack" on GWAS data by Homer et al. (2008) Traditional…

Applications · Statistics 2014-02-10 Fei Yu , Stephen E. Fienberg , Aleksandra Slavković , Caroline Uhler

The projected increase of genotyping in the clinic and the rise of large genomic databases has led to the possibility of using patient medical data to perform genomewide association studies (GWAS) on a larger scale and at a lower cost than…

Quantitative Methods · Quantitative Biology 2016-04-18 Sean Simmons , Cenk Sahinalp , Bonnie Berger

Genome-wide association studies (GWAS) are an essential tool in biomedical research for identifying genetic factors linked to health and disease. However, publicly releasing GWAS summary statistics poses well-recognized privacy risks,…

Quantitative Methods · Quantitative Biology 2025-12-05 Anupama Nandi , Seth Neel , Hyunghoon Cho

Genome-wide Association Studies (GWASes) identify genomic variations that are statistically associated with a trait, such as a disease, in a group of individuals. Unfortunately, careless sharing of GWAS statistics might give rise to privacy…

Genomics · Quantitative Biology 2022-09-21 Túlio Pascoal , Jérémie Decouchant , Antoine Boutet , Marcus Völp

Genome-wide association studies are pivotal in understanding the genetic underpinnings of complex traits and diseases. Collaborative, multi-site GWAS aim to enhance statistical power but face obstacles due to the sensitive nature of genomic…

Cryptography and Security · Computer Science 2025-12-12 Arjhun Swaminathan , Anika Hannemann , Ali Burak Ünal , Nico Pfeifer , Mete Akgün

As genomic research has grown increasingly popular in recent years, dataset sharing has remained limited due to privacy concerns. This limitation hinders the reproducibility and validation of research outcomes, both of which are essential…

Cryptography and Security · Computer Science 2025-04-02 Yuzhou Jiang , Tianxi Ji , Erman Ayday

Genome-wide association studies (GWAS) identify correlations between the genetic variants and an observable characteristic such as a disease. Previous works presented privacy-preserving distributed algorithms for a federation of genome data…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-09-21 Túlio Pascoal , Jérémie Decouchant , Marcus Völp

Following the publication of an attack on genome-wide association studies (GWAS) data proposed by Homer et al., considerable attention has been given to developing methods for releasing GWAS data in a privacy-preserving way. Here, we…

Machine Learning · Statistics 2014-07-31 Fei Yu , Michal Rybar , Caroline Uhler , Stephen E. Fienberg

A major challenge for machine learning is increasing the availability of data while respecting the privacy of individuals. Here we combine the provable privacy guarantees of the differential privacy framework with the flexibility of…

Machine Learning · Statistics 2019-01-18 Michael Thomas Smith , Max Zwiessele , Neil D. Lawrence

Differential privacy is known to protect against threats to validity incurred due to adaptive, or exploratory, data analysis -- even when the analyst adversarially searches for a statistical estimate that diverges from the true value of the…

Cryptography and Security · Computer Science 2022-07-25 Elbert Du , Cynthia Dwork

One goal of statistical privacy research is to construct a data release mechanism that protects individual privacy while preserving information content. An example is a {\em random mechanism} that takes an input database $X$ and outputs a…

Statistics Theory · Mathematics 2012-01-11 Larry Wasserman , Shuheng Zhou

In modern settings of data analysis, we may be running our algorithms on datasets that are sensitive in nature. However, classical machine learning and statistical algorithms were not designed with these risks in mind, and it has been…

Data Structures and Algorithms · Computer Science 2021-08-21 Huanyu Zhang

The increasing prevalence of high-dimensional data across various applications has raised significant privacy concerns in statistical inference. In this paper, we propose a differentially private integrated statistic for testing…

Methodology · Statistics 2025-06-04 Shiwei Sang , Yicheng Zeng , Xuehu Zhu , Shurong Zheng

Data stewards and analysts can promote transparent and trustworthy science and policy-making by facilitating assessments of the sensitivity of published results to alternate analysis choices. For example, researchers may want to assess…

Methodology · Statistics 2023-08-24 Chengxin Yang , Jerome P. Reiter

Disclosure avoidance (DA) systems are used to safeguard the confidentiality of data while allowing it to be analyzed and disseminated for analytic purposes. These methods, e.g., cell suppression, swapping, and k-anonymity, are commonly…

Cryptography and Security · Computer Science 2023-01-31 Keyu Zhu , Ferdinando Fioretto , Pascal Van Hentenryck , Saswat Das , Christine Task

Genome-wide association studies (GWAS) have identified hundreds of loci at very stringent levels of statistical significance across many different human traits. However, it is now clear that very large samples (n~10^4-10^5) are needed to…

Genomics · Quantitative Biology 2013-08-20 Inti Pedroso

Privacy-preserving genomic data sharing is prominent to increase the pace of genomic research, and hence to pave the way towards personalized genomic medicine. In this paper, we introduce ($\epsilon , T$)-dependent local differential…

Cryptography and Security · Computer Science 2021-02-16 Emre Yilmaz , Tianxi Ji , Erman Ayday , Pan Li

Motivated by understanding the dynamics of sensitive social networks over time, we consider the problem of continual release of statistics in a network that arrives online, while preserving privacy of its participants. For our privacy…

Cryptography and Security · Computer Science 2018-09-20 Shuang Song , Susan Little , Sanjay Mehta , Staal Vinterbo , Kamalika Chaudhuri

Differential privacy is the leading mathematical framework for privacy protection, providing a probabilistic guarantee that safeguards individuals' private information when publishing statistics from a dataset. This guarantee is achieved by…

Methodology · Statistics 2025-08-19 Yuki Ohnishi , Jordan Awan

Differentially Private (DP) data release is a promising technique to disseminate data without compromising the privacy of data subjects. However the majority of prior work has focused on scenarios where a single party owns all the data. In…

Cryptography and Security · Computer Science 2022-06-22 Ruihan Wu , Xin Yang , Yuanshun Yao , Jiankai Sun , Tianyi Liu , Kilian Q. Weinberger , Chong Wang
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