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With the rise of Large Language Models(LLMs), it has become crucial to understand their capabilities and limitations in deciphering and explaining the complex web of causal relationships that language entails. Current methods use either…

Retrospective causal questions ask what would have happened to an observed individual had they received a different treatment. We study the problem of estimating $\mu(x,y)=\mathbb{E}[Y(1)\mid X=x,Y(0)=y]$, the expected counterfactual…

Methodology · Statistics 2026-03-31 Juraj Bodik

We consider continuous-time survival or more general event-history settings, where the aim is to infer the causal effect of a time-dependent treatment process. This is formalised as the effect on the outcome event of a (possibly…

Methodology · Statistics 2024-04-23 Kjetil Røysland , Pål Ryalen , Mari Nygård , Vanessa Didelez

We propose semi- and non-parametric methods to estimate conditional interventional effects in the setting of two discrete mediators whose causal ordering is unknown. Average interventional indirect effects have been shown to decompose an…

Methodology · Statistics 2023-04-19 Max Rubinstein , Zach Branson , Edward H. Kennedy

With reference to a single mediator context, this brief report presents a model-based strategy to estimate counterfactual direct and indirect effects when the response variable is ordinal and the mediator is binary. Postulating a logistic…

Methodology · Statistics 2022-10-25 Elena Stanghellini , Maria Kateri

Random-effects meta-analyses are very commonly used in medical statistics. Recent methodological developments include multivariate (multiple outcomes) and network (multiple treatments) meta-analysis. Here we provide a new model and…

Methodology · Statistics 2017-08-16 Dan Jackson , Sylwia Bujkiewicz , Martin Law , Richard D Riley , Ian White

We discuss causal mediation analyses for survival data and propose a new approach based on the additive hazards model. The emphasis is on a dynamic point of view, that is, understanding how the direct and indirect effects develop over time.…

Mediation analysis has traditionally focused on outcome-level summary contrasts, such as mean effects, which may obscure substantial distributional changes induced by complex and nonlinear causal mechanisms. We propose Distributional Causal…

Machine Learning · Statistics 2026-05-05 Jinlun Zhang , Haoneng Huang , Zishu Zhan , Chunquan Ou

Unmeasured confounding presents a common challenge in observational studies, potentially making standard causal parameters unidentifiable without additional assumptions. Given the increasing availability of diverse data sources, exploiting…

Methodology · Statistics 2023-09-18 Shanshan Luo , Yechi Zhang , Wei Li

The average causal mediation effect (ACME) and the natural direct effect (NDE) are two parameters of primary interest in causal mediation analysis. However, the two causal parameters are not identifiable from randomized experimental data in…

Methodology · Statistics 2025-09-04 Wei Liang , Changbao Wu

Political scientists are increasingly interested in assessing causal mechanisms, or determining not just if a causal effect exists but also why it occurs. Even so, many researchers avoid formal causal mediation analyses due to their…

Applications · Statistics 2024-11-21 Matthew Blackwell , Ruofan Ma , Aleksei Opacic

This article contributes to the discussion on the relationship between the Neyman-Rubin and the graphical frameworks for causal inference. We present specific examples of data-generating mechanisms - such as those involving undirected or…

Methodology · Statistics 2025-12-11 Tetiana Gorbach , Xavier de Luna , Juha Karvanen , Ingeborg Waernbaum

We study the identification and estimation of long-term treatment effects when both experimental and observational data are available. Since the long-term outcome is observed only after a long delay, it is not measured in the experimental…

Methodology · Statistics 2024-09-04 Guido Imbens , Nathan Kallus , Xiaojie Mao , Yuhao Wang

Along with the increasing availability of health data has come the rise of data-driven models to inform decision-making and policy. These models have the potential to benefit both patients and health care providers but can also exacerbate…

Methodology · Statistics 2023-10-16 Solvejg Wastvedt , Jared Huling , Julian Wolfson

Causal mediation analysis concerns the pathways through which a treatment affects an outcome. While most of the mediation literature focuses on settings with a single mediator, a flourishing line of research has examined settings involving…

Methodology · Statistics 2021-11-12 Xiang Zhou

Counterfactual prompting (i.e., perturbing a single factor and measuring output change) is widely used to evaluate things like LLM bias and CoT faithfulness. But in this work we argue that observed effects cannot be attributed to the…

Computation and Language · Computer Science 2026-05-05 Zihao Yang , Mosh Levy , Yoav Goldberg , Byron C. Wallace

This PhD thesis contains several contributions to the field of statistical causal modeling. Statistical causal models are statistical models embedded with causal assumptions that allow for the inference and reasoning about the behavior of…

Machine Learning · Statistics 2021-10-05 Martin Emil Jakobsen

Intensive longitudinal data, characterized by frequent measurements across numerous time points, are increasingly common due to advances in wearable devices and mobile health technologies. We consider evaluating causal mediation pathways…

Methodology · Statistics 2025-06-26 Tianchen Qian

In causal inference, interference occurs when the treatment of one unit may affect the outcomes of other units. The goal of this work is to serve as a guide to the use of linear outcome modeling for estimating causal effects in settings…

Methodology · Statistics 2026-04-01 Eric Tong , Salvador V. Balkus

Skepticism about the assumption of no unmeasured confounding, also known as exchangeability, is often warranted in making causal inferences from observational data; because exchangeability hinges on an investigator's ability to accurately…

Methodology · Statistics 2023-02-22 Yifan Cui , Hongming Pu , Xu Shi , Wang Miao , Eric Tchetgen Tchetgen