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Most evolutionary-oriented deep generative models do not explicitly consider the underlying evolutionary dynamics of biological sequences as it is performed within the Bayesian phylogenetic inference framework. In this study, we propose a…

Machine Learning · Computer Science 2022-07-04 Amine M. Remita , Abdoulaye Baniré Diallo

We provide a unified framework to compute the stationary distribution of any finite irreducible Markov chain or equivalently of any irreducible random walk on a finite semigroup $S$. Our methods use geometric finite semigroup theory via the…

Probability · Mathematics 2019-03-11 John Rhodes , Anne Schilling

This work considers the problem of learning the structure of multivariate linear tree models, which include a variety of directed tree graphical models with continuous, discrete, and mixed latent variables such as linear-Gaussian models,…

Machine Learning · Computer Science 2011-11-09 Animashree Anandkumar , Kamalika Chaudhuri , Daniel Hsu , Sham M. Kakade , Le Song , Tong Zhang

When the process underlying DNA substitutions varies across evolutionary history, the standard Markov models underlying standard phylogenetic methods are mathematically inconsistent. The most prominent example is the general time reversible…

Populations and Evolution · Quantitative Biology 2014-12-05 Michael D. Woodhams , Jesús Fernández-Sánchez , Jeremy G. Sumner

It is known that the Kimura 3ST model of sequence evolution on phylogenetic trees can be extended quite naturally to arbitrary split systems. However, this extension relies heavily on mathematical peculiarities of the K3ST model, and…

Populations and Evolution · Quantitative Biology 2012-04-24 J. G. Sumner , B. H. Holland , P. D. Jarvis

We address high dimensional covariance estimation for elliptical distributed samples, which are also known as spherically invariant random vectors (SIRV) or compound-Gaussian processes. Specifically we consider shrinkage methods that are…

Methodology · Statistics 2015-05-20 Yilun Chen , Ami Wiesel , Alfred O. Hero

The aim of this review is to present and analyze the probabilistic models of mathematical phylogenetics which have been intensively used in recent years in biology as the cornerstone of attempts to infer and reconstruct the ancestral…

Populations and Evolution · Quantitative Biology 2020-01-08 Peter D Jarvis , Jeremy G Sumner

An approximation algorithm is proposed to transform truncated QCD (or QED) series for observables. The approximation is a modification of the Baker-Gammel approximants, and is independent of the renormalization scale (RScl) $\mu$ -- the…

High Energy Physics - Phenomenology · Physics 2009-10-30 G. Cvetic

We apply the recently proposed Sample-based Krylov Quantum Diagonalization (SKQD) method to lattice gauge theories, using the Schwinger model with a $\theta$-term as a benchmark. SKQD approximates the ground state of a Hamiltonian,…

Standard Gaussian graphical models (GGMs) implicitly assume that the conditional independence among variables is common to all observations in the sample. However, in practice, observations are usually collected form heterogeneous…

Methodology · Statistics 2010-01-26 Abel Rodriguez , Alex Lenkoski , Adrian Dobra

Scene Graph Generation (SGG) suffers from a long-tailed distribution, where a few predicate classes dominate while many others are underrepresented, leading to biased models that underperform on rare relations. Unbiased-SGG methods address…

Computer Vision and Pattern Recognition · Computer Science 2026-01-14 Runfeng Qu , Ole Hall , Pia K Bideau , Julie Ouerfelli-Ethier , Martin Rolfs , Klaus Obermayer , Olaf Hellwich

Linear mixed-effects models are widely used in analyzing clustered or repeated measures data. We propose a quasi-likelihood approach for estimation and inference of the unknown parameters in linear mixed-effects models with high-dimensional…

Methodology · Statistics 2021-03-10 Sai Li , Tony T. Cai , Hongzhe Li

Phylogenetic networks can represent evolutionary events that cannot be described by phylogenetic trees. These networks are able to incorporate reticulate evolutionary events such as hybridization, introgression, and lateral gene transfer.…

Populations and Evolution · Quantitative Biology 2021-07-08 Elizabeth Gross , Leo van Iersel , Remie Janssen , Mark Jones , Colby Long , Yukihiro Murakami

Generalized additive models (GAMs) are flexible non-linear regression models, which can be fitted efficiently using the approximate Bayesian methods provided by the mgcv R package. While the GAM methods provided by mgcv are based on the…

Methodology · Statistics 2020-07-08 Matteo Fasiolo , Simon N. Wood , Margaux Zaffran , Raphaël Nedellec , Yannig Goude

We develop a general geometric method to establish the existence of positive Lyapunov exponents for a class of skew products. The technique is applied to show non-uniform hyperbolicity of some conservative partially hyperbolic…

Dynamical Systems · Mathematics 2020-04-02 Pablo D. Carrasco

Multi-model inference covers a wide range of modern statistical applications such as variable selection, model confidence set, model averaging and variable importance. The performance of multi-model inference depends on the availability of…

Statistics Theory · Mathematics 2019-06-07 Ching-Wei Cheng , Guang Cheng

Itemset mining has been an active area of research due to its successful application in various data mining scenarios including finding association rules. Though most of the past work has been on finding frequent itemsets, infrequent…

Databases · Computer Science 2012-07-23 Ashish Gupta , Akshay Mittal , Arnab Bhattacharya

Recently-developed genotype imputation methods are a powerful tool for detecting untyped genetic variants that affect disease susceptibility in genetic association studies. However, existing imputation methods require individual-level…

Applications · Statistics 2010-11-15 Xiaoquan Wen , Matthew Stephens

This paper develops asymptotic theory for quantile estimation via stochastic gradient descent (SGD) with a constant learning rate. The quantile loss function is neither smooth nor strongly convex. Beyond conventional perspectives and…

Machine Learning · Statistics 2026-04-06 Ziyang Wei , Jiaqi Li , Likai Chen , Wei Biao Wu

Generative modeling is one of the most promising applications of quantum machine learning, yet training and deploying Quantum Generative Models (QGMs) on near-term hardware remains effectively intractable due to prohibitive gradient…