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Nanopore sensing is a versatile technique for the analysis of molecules on the single-molecule level. However, extracting information from data with established algorithms usually requires time-consuming checks by an experienced researcher…

Quantitative Methods · Quantitative Biology 2018-06-14 Karolis Misiunas , Niklas Ermann , Ulrich F. Keyser

The high flexibility, impermeability and strength of graphene membranes are key properties that can enable the next generation of nanomechanical sensors. However, for capacitive pressure sensors the sensitivity offered by a single suspended…

Based on our formulation of the DNA electrophoresis near a pore [P. Rowghanian and A. Y. Grosberg, Phys. Rev. E 87, 042723 (2013)], we address the electrophoretic DNA capture into a nanopore as a steady-state process of particle absorption…

Biological Physics · Physics 2013-06-20 Payam Rowghanian , Alexander Y. Grosberg

This work presents an innovative magnetoelastic (ME) biosensor using graphene functionalized with the SARS-CoV-2 N protein for antibody detection via magnetoelastic resonance. Graphene was chosen for its biocompatibility and high surface…

Nanopore protein sequencing produces long, noisy ionic current traces in which key molecular phases, such as protein capture and translocation, are embedded. Capture phases mark the successful entry of a protein into the pore and serve as…

Machine Learning · Computer Science 2025-11-04 Annabelle Martin , Daphne Kontogiorgos-Heintz , Jeff Nivala

Vapor sensors based on functionalized carbon nanotubes (NTs) have shown great promise, with high sensitivity conferred by the reduced dimensionality and exceptional electronic properties of the NT. Critical challenges in the development of…

Graphene's optical properties in the infrared and terahertz can be tailored and enhanced by patterning graphene into periodic metamaterials with sub-wavelength feature sizes. Here we demonstrate polarization sensitive and gate tunable…

Mesoscale and Nanoscale Physics · Physics 2013-06-05 Marcus Freitag , Tony Low , Wenjuan Zhu , Hugen Yan , Fengnian Xia , Phaedon Avouris

Solid-state nanopores are single molecule sensors that measure changes in ionic current as charged polymers such as DNA pass through. Here, we present comprehensive experiments on the length, voltage and salt dependence of the frequency of…

Biological Physics · Physics 2016-03-23 Nicholas A. W. Bell , Murugappan Muthukumar , Ulrich F. Keyser

The translocation of double-stranded DNA through a solid-state nanopore may either decrease or increase the ionic current depending on the ionic concentration of the surrounding solution. Below a certain crossover ionic concentration, the…

Biological Physics · Physics 2019-09-04 Vivian Wang , Niklas Ermann , Ulrich F. Keyser

Nanopore sequencing accuracy is inherently limited by the quality of data from individual molecular translocation events, requiring advances beyond traditional sequencing-by-synthesis methods. We introduce an oxidized pyramidal sub-nm pore…

Applied Physics · Physics 2026-05-22 Jianxin Yang , Dehua Hu , Wu Yuan , Tianle Pan , Ho-Pui Ho

The graphene membrane irradiated by weak activating alternative electric field in terahertz range was considered. The quantum approach based on the time-dependent density matrix method was used. The exact solution was obtained for graphene…

Mesoscale and Nanoscale Physics · Physics 2015-11-18 N. E. Firsova , Yu. A. Firsov

Graphene based sensor to gas molecules should be ultrasensitive and ultrafast because of the single-atomic thickness of graphene, while the response is not fast. Usually, the measured response time for many molecules, such as CO, NH3, SO2,…

Mesoscale and Nanoscale Physics · Physics 2019-07-09 Hui-Fen Zhang , Bo-Yuan Ning , Tsu-Chien Weng , Dong-Ping Wu , Xi-Jing Ning

Recently synthesized Porous 12-Atom-Wide Armchair Graphene Nanoribbons Nano Lett. 2024, 24, 10718-10723 exhibit tunable properties through periodic porosity, enabling precise control over their electronic, optical, thermal, and mechanical…

A tandem cell is proposed for DNA sequencing in which an exonuclease enzyme cleaves bases (mononucleotides) from a strand of DNA for identification inside a nanopore. It has two nanopores and three compartments with the structure [cis1,…

Biomolecules · Quantitative Biology 2014-08-21 G. Sampath

DNA methylation plays a pivotal role in the genetic evolution of both embryonic and adult cells. For adult somatic cells, location and dynamics of methylation has been very precisely pinned down with the 5-cytosine markers on…

Mesoscale and Nanoscale Physics · Physics 2014-06-04 Towfiq Ahmed , Jason T. Haraldsen , Jian-Xin Zhu , Alexander V. Balatsky

Miniature DNA sequencing hardware has begun to succeed in mobile contexts, driving demand for efficient machine learning at the edge. This domain leverages deep learning techniques familiar from speech and time-series analysis for both…

Hardware Architecture · Computer Science 2025-10-13 Sebastian Magierowski , Zhongpan Wu , Abel Beyene , Karim Hammad

We investigate the dynamics of DNA translocation through a nanopore using 2D Langevin dynamics simulations, focusing on the dependence of the translocation dynamics on the details of DNA sequences. The DNA molecules studied in this work are…

Soft Condensed Matter · Physics 2008-02-05 Kaifu Luo , Tapio Ala-Nissila , See-Chen Ying , Aniket Bhattacharya

Lasers based on biological materials are attracting an increasing interest in view of their use in integrated and transient photonics. DNA as optical biopolymer in combination with highly-emissive dyes has been reported to have excellent…

We developed a nanoplasmonic sensor platform employing the extraordinary optical properties of one-dimensional nanogratings patterned on 30nm-thick ultrathin Ag films. Excitation of Fano resonances in the ultrathin Ag nanogratings results…

Optics · Physics 2014-10-15 Beibei Zeng , Yongkang Gao , Filbert J. Bartoli

Methods for reducing and directly controlling the speed of DNA through a nanopore are needed to enhance sensing performance for direct strand sequencing and detection/mapping of sequence-specific features. We have created a method for…

Biological Physics · Physics 2018-11-28 Xu Liu , Yuning Zhang , Roland Nagel , Walter Reisner , William B. Dunbar
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