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Complementary DNA strands in solution reliably hybridize to form stable duplexes. We study the kinetics of the hybridization process and the mechanisms by which two initially isolated strands come together to form a stable double helix. We…

Biological Physics · Physics 2019-03-27 Raymond Jin , Lutz Maibaum

Complementary strands in DNA double helix show temporary fluctuational openings which are essential to biological functions such as transcription and replication of the genetic information. Such large amplitude fluctuations, known as the…

Biological Physics · Physics 2013-02-12 Marco Zoli

DNA cyclization is a powerful technique to gain insight into the nature of DNA bending. The worm-like chain model provides a good description of small to moderate bending fluctuations, but some experiments on strongly-bent shorter molecules…

Biomolecules · Quantitative Biology 2021-12-03 Ryan M. Harrison , Flavio Romano , Thomas E. Ouldridge , Ard A. Louis , Jonathan P. K. Doye

A study of the micromechanical unzipping of DNA in the framework of the Peyrard-Bishop-Dauxois model is presented. We introduce a Monte Carlo technique that allows accurate determination of the dependence of the unzipping forces on…

Soft Condensed Matter · Physics 2007-05-23 N. K. Voulgarakis , A. Redondo , A. R. Bishop , K. O. Rasmussen

Properties of the two dimensional Ising model with fixed magnetization are deduced from known exact results on the two dimensional Ising model. The existence of a continuous phase transition is shown for arbitrary values of the fixed…

Statistical Mechanics · Physics 2007-05-23 Michael Kastner

When pulled along the axis, double-strand DNA undergoes a large conformational change and elongates roughly twice its initial contour length at a pulling force about 70 pN. The transition to this highly overstretched form of DNA is very…

Soft Condensed Matter · Physics 2008-09-11 Mogurampelly Santosh , Prabal K Maiti

We introduce a driven diffusive model involving poly-dispersed hard k-mers on a one dimensional periodic ring and investigate the possibility of phase separation transition in such systems. The dynamics consists of a size dependent…

Statistical Mechanics · Physics 2015-06-23 Bijoy Daga , P. K. Mohanty

The nonequilibrium dynamic phase transition in ferromagnetic systems is reviewed. Very recent results of dynamic transition in kinetic Ising model and that in Heisenberg ferromagnet is discussed.

Statistical Mechanics · Physics 2013-02-15 Muktish Acharyya

We present an extensive theoretical investigation of the mechanical unzipping of double-stranded DNA under the influence of an applied force. In the limit of long polymers, there is a thermodynamic unzipping transition at a critical force…

Soft Condensed Matter · Physics 2009-11-07 David K. Lubensky , David R. Nelson

We investigate the driven states of a two-dimensional crystal whose ground state can be tuned through a square-triangular transition. The depinning of such a system from a quenched random background potential occurs via a complex sequence…

Statistical Mechanics · Physics 2009-11-11 Ankush Sengupta , Surajit Sengupta , Gautam I. Menon

Previous numerical investigations of an one-dimensional DNA model with an extended modified coupling constant by transcripting enzyme are integrated to longer time and demonstrated explicitly the trapping of breathers by DNA chains with…

solv-int · Physics 2021-01-21 Julian Juhi-Lian Ting

The formation of polarized signaling domains on cell membranes is a fundamental example of biological pattern formation. While such patterns resemble structures from equilibrium phase separation, they are intrinsically non-equilibrium,…

Biological Physics · Physics 2025-12-10 Damiano Andreghetti , Alfredo Braunstein , Luca Dall'Asta , Andrea Gamba

A mathematical model for a two-gene regulatory network is derived and several of their properties analyzed. Due to the presence of mixed continuous/discrete dynamics and hysteresis, we employ a hybrid systems model to capture the dynamics…

Systems and Control · Computer Science 2014-02-04 Qin Shu , Ricardo G. Sanfelice

All living systems can function only far away from equilibrium, and for this reason chemical kinetic methods are critically important for uncovering the mechanisms of biological processes. Here we present a new theoretical method of…

Subcellular Processes · Quantitative Biology 2018-04-27 Maria P. Kochugaeva , Alexey A. Shvets , Anatoly B. Kolomeisky

We study a 1D-Quantum Ising Model in transverse field driven out of equilibrium by performing a composite quantum quench to deduce the asymptotic properties of the transverse magnetization stationary state via the analysis of the spectral…

Statistical Mechanics · Physics 2019-11-06 Giulia Piccitto , Alessandro Silva

We study numerically the phase diagram and the response under a driving force of the phase field crystal model for pinned lattice systems introduced recently for both one and two dimensional systems. The model describes the lattice system…

Materials Science · Physics 2009-09-30 C. V. Achim , J. A. P. Ramos , M. Karttunen , K. R. Elder , E. Granato , T. Ala-Nissila , S. C. Ying

In living systems, DNA undergoes continuous and rhythmic mechanical remodeling through condensation, looping, and disentangling to regulate gene expression, segregate chromosomes, and guide morphogenesis. Here, we demonstrate a purely…

Soft Condensed Matter · Physics 2025-12-01 Maya Levanon , Noa S. Goldberg , Dvir Cohen , Eran Bouchbinder , Ram M. Adar , Alexandra M. Tayar

We propose a periodically driven system whose dimensionality is an emergent property that can be tunable, thus enables us to realize not only many-body phases with arbitrary dimensions, but also phase transitions, instead of crossovers,…

Statistical Mechanics · Physics 2025-03-13 Zhizhen Chen , Zi Cai

Test experiments of hybridization in DNA microarrays show systematic deviations from the equilibrium isotherms. We argue that these deviations are due to the presence of a partially hybridized long-lived state, which we include in a kinetic…

Biomolecules · Quantitative Biology 2010-06-16 J. Hooyberghs , M. Baiesi , A. Ferrantini , E. Carlon

Cells often exhibit different and stable phenotypes from the same DNA sequence. Robustness and plasticity of such cellular states are controlled by diverse transcriptional and epigenetic mechanisms, among them the modification of…

Molecular Networks · Quantitative Biology 2015-06-18 Daniel Jost