Related papers: Desynchronizing effect of high-frequency stimulati…
Electrical coupling between neurons is broadly present across brain areas and is typically assumed to synchronize network activity. However, intrinsic properties of the coupled cells can complicate this simple picture. Many cell types with…
Objective: The objective of this study is to develop and evaluate a systematic approach to optimize Deep Brain Stimulation (DBS) parameters, addressing the challenge of identifying patient-specific settings and optimal stimulation targets…
Parkinson's disease (PD) is a degenerative condition of the nervous system, which manifests itself primarily as muscle stiffness, hypokinesia, bradykinesia, and tremor. In patients suffering from advanced stages of PD, Deep Brain…
Multichannel transcranial current stimulation (tCS) systems offer the possibility of EEG-guided optimized, non-invasive brain stimulation. In this brief technical note I explain how it is possible to use tCS electric field realistic brain…
Transcranial magnetic stimulation (TMS) with asymmetric electric field pulses, such as monophasic, offers directional selectivity for neural activation but requires excessive energy. Previous pulse shape optimisation has been limited to…
Brain activity following stimulus presentation and during resting state are often the result of highly coordinated responses of large numbers of neurons both locally and globally. Coordinated activity of neurons can give rise to…
Cortical slow oscillations occur in the mammalian brain during deep sleep and have been shown to contribute to memory consolidation, an effect that can be enhanced by electrical stimulation. As the precise underlying working mechanisms are…
Diffuse Correlation Spectroscopy (DCS) allows the label-free investigation of microvascular dynamics deep within living tissue. However, common implementations of DCS are currently limited to measurement depths of $\sim 1-1.5cm$, which can…
It is widely assumed that neural activity related to synchronous rhythms of large portions of neurons in specific locations of the brain is responsible for the pathology manifested in patients' uncontrolled tremor and other similar…
Functional connectivity (FC) between brain regions tracks symptom severity in many neuropsychiatric disorders. Transcranial magnetic stimulation (TMS) directly alters regional activity and indirectly alters FC. Predicting how FC will change…
Spinal cord injury (SCI) is a debilitating condition that often results in significant motor and sensory deficits, impacting the quality of life. Current rehabilitation methods, including physical therapy and electrical stimulation, offer…
There has become of increasing interest in transcranial alternating current stimulation (tACS) since its inception nearly a decade ago. tACS in modulating brain state is an active area of research and has been demonstrated effective in…
Deep brain stimulation (DBS) is an established intervention for Parkinson's disease (PD), but conventional open-loop systems lack adaptability, are energy-inefficient due to continuous stimulation, and provide limited personalization to…
In neural-decoding studies, recordings of participants' responses to stimuli are used to train models. In recent years, there has been an explosion of publications detailing applications of innovations from deep-learning research to…
Noninvasive brain stimulation (NIBS) by quasistatic electromagnetic means is presently comprised of two methods: Magnetic induction methods (Transcranial magnetic perturbation or TMP) and electrical contact methods (Transcranial electric…
The underlying dynamics for the electroencephalographic (EEG) recordings from humans but especially epilepsy patients are usually not completely known. However, the ictal activity is claimed to be characterized by synchronous oscillations…
Electrical high frequency stimulation (HFS) of deep brain regions is a method shown to be clinically effective in different types of movement and neurological disorders. In order to shed light on its mode of action a computational model of…
Deep brain stimulation (DBS) has shown great promise toward treating motor symptoms caused by Parkinson's disease (PD), by delivering electrical pulses to the Basal Ganglia (BG) region of the brain. However, DBS devices approved by the U.S.…
Objectives: Permissible limits have been established by international guidelines and standards for human protection to electromagnetic field exposure to prevent adverse health effects stemming from electrostimulation in the most sensitive…
Neural synchronization is believed to be critical for many brain functions. It frequently exhibits temporal variability, but it is not known if this variability has a specific temporal patterning. This study explores these…