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Synthetic genetic circuits are implemented in living cells for their operation. During gene expression, proteins are produced from the respective genes, by formation of complexes through the process of transcription and translation. In…

Molecular Networks · Quantitative Biology 2021-12-10 Priya Chakraborty , Sayantari Ghosh

mRNA translation is a crucial process that leads to protein synthesis in living cells. Therefore, it is a process that needs to work optimally for a cell to stay healthy and alive. With advancements in microscopy and novel experimental…

Subcellular Processes · Quantitative Biology 2023-12-20 Binil Shyam T , Rati Sharma

We investigate the effects of competition in a problem of resource extraction from a common source with diffusive dynamics. In the symmetric version with identical extraction rates we prove the existence of a Nash equilibrium where the…

Optimization and Control · Mathematics 2021-06-10 Erik Ekström , Kristoffer Lindensjö

The entanglement of population dynamics, evolution, and adaptive radiation for species competing for resources is studied. For resource harvesting, we modify the model used in Ref. Phys. Rev. Lett. 118 048103 and introduce new resource…

Populations and Evolution · Quantitative Biology 2023-10-03 Sergei V. Koniakhin

Large-scale simultaneous mRNA translation and the resulting competition for the available ribosomes has important implications to the cell's functioning and evolution. Developing a better understanding of the intricate correlations between…

Genomics · Quantitative Biology 2015-08-12 Alon Raveh , Michael Margaliot , Eduardo D. Sontag , Tamir Tuller

Cell competition is a quality control mechanism in tissues that results in the elimination of less fit cells. Over the past decade, the phenomenon of cell competition has been identified in many physiological and pathological contexts,…

Tissues and Organs · Quantitative Biology 2019-03-26 Daniel Gradeci , Anna Bove , Guillaume Charras , Alan R. Lowe , Shiladitya Banerjee

Cell reproduction involves replication of diverse molecule species, in contrast to simple replication system with fewer components. Here, we address why such diversity is sustained despite the efficiency of simple replication systems, using…

Cell Behavior · Quantitative Biology 2016-07-06 Atsushi Kamimura , Kunihiko Kaneko

We consider a family of totally asymmetric simple exclusion processes (TASEPs), consisting of particles on a lattice that require binding by a "token" in various physical configurations to advance over the lattice. Using a combination of…

Statistical Mechanics · Physics 2025-02-11 Bor Kavčič , Gašper Tkačik

In science as elsewhere, attention is a limited resource and scientists compete with one another to produce the most exciting, novel and impactful results. We develop a game-theoretic model to explore how such competition influences the…

Physics and Society · Physics 2025-09-09 Kevin Gross , Carl T. Bergstrom

Translation is one of the main steps in the synthesis of proteins. It consists of ribosomes that translate sequences of nucleotides encoded on mRNA into polypeptide sequences of amino acids. Ribosomes bound to mRNA move unidirectionally,…

Subcellular Processes · Quantitative Biology 2022-01-19 Olivier Dauloudet , Izaak Neri , Jean-Charles Walter , Jérôme Dorignac , Frédéric Geniet , Andrea Parmeggiani

How does competition in markets for information affect the creation and division of surplus? We study this question in a search environment in which an agent searches sequentially for a high-quality good and learns about the quality of…

Theoretical Economics · Economics 2026-05-26 Teddy Mekonnen , Bobak Pakzad-Hurson

We study the competition and the evolution of nodes embedded in Euclidean restricted spaces. The population evolves by a branching process in which new nodes are generated when up to two new nodes are attached to the previous ones at each…

Populations and Evolution · Quantitative Biology 2014-07-21 Fabricio L. Forgerini , Nuno Crokidakis

A discrete-time totally asymmetric simple exclusion process on a lattice with open boundaries is considered. There are particles of different types. The type of a particle is characterized by the probability that a particle moves to a…

Statistical Mechanics · Physics 2025-11-04 Marina V. Yashina , Alexander G. Tatashev

We demonstrate how concepts of statistical mechanics of interacting particles can have important implications in the choice of interaction potentials to model qualitative properties of cell aggregates in theoretical biology. We illustrate…

Cell Behavior · Quantitative Biology 2017-06-29 J. A. Carrillo , A. Colombi , M. Scianna

Mechanical forces influence the dynamics of growing tissues. Computer simulations are employed to study the importance of interfacial effects in tissue competition. It was speculated that mechanical pressure determines the competition,…

Biological Physics · Physics 2024-06-03 Nirmalendu Ganai , Tobias Buscher , Gerhard Gompper , Jens Elgeti

I study how organisations choose selection procedures in a competitive environment. Two firms compete to hire candidates of unknown productivity from a common pool. Firms simultaneously post a selection procedure which consists of a test…

Theoretical Economics · Economics 2026-05-01 Nathan Hancart

We study a spatially homogeneous model of a market where several agents or companies compete for a wealth resource. In analogy with ecological systems the simplest case of such models shows a kind of "competitive exclusion" principle.…

Condensed Matter · Physics 2009-11-07 Marcelo Kuperman And Horacio Wio

Does a high dispersal rate provide a competitive advantage when risking competitive exclusion? To this day, the theoretical literature cannot answer this question in full generality. The present paper focuses on the simplest mathematical…

Analysis of PDEs · Mathematics 2020-02-24 Léo Girardin

Living cells use readout molecules to record the state of receptor proteins, similar to measurements or copies in typical computational devices. But is this analogy rigorous? Can cells be optimally efficient, and if not, why? We show that,…

Statistical Mechanics · Physics 2017-04-19 Thomas E. Ouldridge , Pieter Rein ten Wolde

We study a model of competition for resource through a chemostat-type model where species consume the common resource that is constantly supplied. We assume that the species and resources are characterized by a continuous trait. As already…

Analysis of PDEs · Mathematics 2014-02-24 Sepideh Mirrahimi , Benoît Perthame , Joe Yuichiro Wakano