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A number of biological rhythms originate from networks comprised of multiple cellular oscillators. But analytical results are still lacking on the collective oscillation period of inter-coupled gene regulatory oscillators, which, as has…

Systems and Control · Computer Science 2014-02-26 Yongqiang Wang , Yutaka Hori , Shinji Hara , Francis J. Doyle

Oscillations represent a ubiquitous phenomenon in biological systems. The conventional models of biological periodic oscillations are usually proposed as interconnecting transcriptional feedback loops. Some specific proteins function as…

Pattern Formation and Solitons · Physics 2013-05-29 Yue Ma , Kenichi Yoshikawa

Biological rhythms are generated by pacemaker organs, such as the heart pacemaker organ (the sinoatrial node) and the master clock of the circadian rhythms (the suprachiasmatic nucleus), which are composed of a network of autonomously…

Cell Behavior · Quantitative Biology 2016-08-23 Hiroshi Kori , Yoji Kawamura , Naoki Masuda

The study on the collective dynamics of synchronization among genetic oscillators is essential for the understanding of the rhythmic phenomena of living organisms at both molecular and cellular levels. Genetic oscillators are biochemical…

Chaotic Dynamics · Physics 2007-05-23 Chunguang Li , Luonan Chen , Kazuyuki Aihara

The onset of synchronization in networks of networks is investigated. Specifically, we consider networks of interacting phase oscillators in which the set of oscillators is composed of several distinct populations. The oscillators in a…

Dynamical Systems · Mathematics 2009-11-13 Ernest Barreto , Brian Hunt , Edward Ott , Paul So

Collective oscillation of cells in a population has been reported under diverse biological contexts and with vastly different molecular constructs. Could there be common principles similar to those that govern spontaneous oscillation in…

Cell Behavior · Quantitative Biology 2019-07-08 Shou-Wen Wang , Lei-Han Tang

Coupled biological oscillators can tick with the same period. How this collective period is established is a key question in understanding biological clocks. We explore this question in the segmentation clock, a population of coupled…

Tissues and Organs · Quantitative Biology 2010-09-03 Leah Herrgen , Saul Ares , Luis G. Morelli , Christian Schroeter , Frank Julicher , Andrew C. Oates

Biological oscillators coordinate individual cellular components so that they function coherently and collectively. They are typically composed of multiple feedback loops, and period mismatch is unavoidable in biological implementations. We…

Biological Physics · Physics 2013-05-06 Yoshihiko Hasegawa , Masanori Arita

We study a system of dynamical units, each of which shows excitable or oscillatory behavior, depending on the choice of parameters. When we couple these units with repressive bonds, we can control the duration of collective oscillations for…

Molecular Networks · Quantitative Biology 2014-02-06 Darka Labavic , Hildegard Meyer-Ortmanns

The emergence of synchronization in a network of coupled oscillators is a pervasive topic in various scientific disciplines ranging from biology, physics, and chemistry to social networks and engineering applications. A coupled oscillator…

Optimization and Control · Mathematics 2012-09-07 Florian Dörfler , Francesco Bullo

We study the synchronization phenomena in a system of globally coupled oscillators with time delay in the coupling. The self-consistency equations for the order parameter are derived, which depend explicitly on the amount of delay. Analysis…

Statistical Mechanics · Physics 2009-10-31 M. Y. Choi , H. J. Kim , D. Kim , H. Hong

Global synchronization in a complex network of oscillators emerges from the interplay between its topology and the dynamics of the pairwise interactions among its numerous components. When oscillators are spatially separated, however, a…

Adaptation and Self-Organizing Systems · Physics 2013-11-28 V. H. P. Louzada , N. A. M. Araújo , J. S. Andrade , H. J. Herrmann

We study the effects of delayed coupling on timing and pattern formation in spatially extended systems of dynamic oscillators. Starting from a discrete lattice of coupled oscillators, we derive a generic continuum theory for collective…

Chaotic Dynamics · Physics 2012-05-21 Saul Ares , Luis G. Morelli , David J. Jorg , Andrew C. Oates , Frank Julicher

We develop a detailed theoretical framework for various types of transcription factor gene oscillators. We further demonstrate that one can build genetic-oscillators which are tunable and robust against perturbations in the critical control…

Molecular Networks · Quantitative Biology 2014-08-13 Rajamanickam Murugan

Network couplings of oscillatory large-scale systems, such as the brain, have a space-time structure composed of connection strengths and signal transmission delays. We provide a theoretical framework, which allows treating the spatial…

Coupled oscillators have been used to study synchronization in a wide range of social, biological, and physical systems, including pedestrian-induced bridge resonances, coordinated lighting up of firefly swarms, and enhanced output peak…

Adaptation and Self-Organizing Systems · Physics 2021-11-01 Can Xu , Xiaohuan Tang , Huaping Lü , Karin Alfaro-Bittner , Stefano Boccaletti , Matjaz Perc , Shuguang Guan

We examine microscopic mechanisms for coupling stochastic oscillators so that they display similar and correlated temporal variations. Unlike oscillatory motion in deterministic dynamical systems, complete synchronization of stochastic…

Quantitative Methods · Quantitative Biology 2009-09-29 Amitabha Nandi , G. Santhosh , R. K. Brojen Singh , Ram Ramaswamy

Networks of coupled nonlinear oscillators have been used to model circadian rhythms, flashing fireflies, Josephson junction arrays, high-voltage electric grids, and many other kinds of self-organizing systems. Recently, several authors have…

Dynamical Systems · Mathematics 2025-10-07 Shriya V. Nagpal , Gokul G. Nair , Steven H. Strogatz , Francesca Parise

Oscillatory chemical reactions often serve as a timing clock of cellular processes in living cells. The temporal dynamics of protein concentration levels is thus of great interest in biology. Here we propose a theoretical framework to…

Systems and Control · Computer Science 2015-03-20 Yutaka Hori , Shinji Hara

Ensembles of phase-oscillators are known to exhibit a variety of collective regimes. Here, we show that a simple mean-field model involving two heterogenous populations of pulse-coupled oscillators, exhibits, in the strong-coupling limit, a…

Disordered Systems and Neural Networks · Physics 2024-07-12 German Mato , Antonio Politi , Alessandro Torcini
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