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Since its introduction by Erik Winfree in 1998, the abstract Tile Assembly Model (aTAM) has inspired a wealth of research. As an abstract model for tile based self-assembly, it has proven to be remarkably powerful and expressive in terms of…

Mathematical Software · Computer Science 2015-03-18 Matthew J. Patitz

Perhaps the two most significant theoretical questions about the programming of self-assembling agents are: (1) necessary and sufficient conditions to produce a unique terminal assembly, and (2) error correction. We address both questions,…

Data Structures and Algorithms · Computer Science 2009-09-16 Aaron Sterling

We show the first asymptotically efficient constructions in the so-called "noncooperative planar tile assembly" model. Algorithmic self-assembly is the study of the local, distributed, asynchronous algorithms ran by molecules to…

Computational Complexity · Computer Science 2021-07-19 Pierre-Etienne Meunier , Damien Regnault

We consider staged self-assembly systems, in which square-shaped tiles can be added to bins in several stages. Within these bins, the tiles may connect to each other, depending on the glue types of their edges. Previous work by Demaine et…

Data Structures and Algorithms · Computer Science 2017-01-03 Erik D. Demaine , Sándor P. Fekete , Christian Scheffer , Arne Schmidt

Tile-based self-assembly systems are capable of universal computation and algorithmically-directed growth. Systems capable of such behavior typically make use of "glue cooperation" in which the glues on at least $2$ sides of a tile must…

Emerging Technologies · Computer Science 2019-03-15 Daniel Hader , Matthew J. Patitz

In this work we propose a generalization of Winfree's abstract Tile Assembly Model (aTAM) in which tile types are assigned rigid shapes, or geometries, along each tile face. We examine the number of distinct tile types needed to assemble…

Computational Geometry · Computer Science 2015-03-19 Bin Fu , Matthew J. Patitz , Robert T. Schweller , Bobby Sheline

We prove a Pumping Lemma for the noncooperative abstract Tile Assembly Model, a model central to the theory of algorithmic self-assembly since the beginning of the field. This theory suggests, and our result proves, that small differences…

Computational Complexity · Computer Science 2020-02-11 Pierre-Étienne Meunier , Damien Regnault , Damien Woods

Algorithmic self-assembly occurs when disorganized components autonomously combine to form structures and, by their design and the dynamics of the system, are forced to follow the execution of algorithms. Motivated by applications in…

Computational Geometry · Computer Science 2023-05-05 Daniel Hader , Matthew J. Patitz

The well-studied Two-Handed Tile Assembly Model (2HAM) is a model of tile assembly in which pairs of large assemblies can bind, or self-assemble, together. In order to bind, two assemblies must have matching glues that can simultaneously…

Computational Geometry · Computer Science 2014-08-22 Erik D. Demaine , Matthew J. Patitz , Trent A. Rogers , Robert T. Schweller , Scott M. Summers , Damien Woods

Sequence-directed assembly processes - such as protein folding - allow the assembly of a large number of structures with high accuracy from only a small handful of fundamental building blocks. We aim to explore how efficiently sequence…

Biological Physics · Physics 2025-03-14 Jeremy Guntoro , Thomas Ouldridge

In this paper we explore the power of tile self-assembly models that extend the well-studied abstract Tile Assembly Model (aTAM) by permitting tiles of shapes beyond unit squares. Our main result shows the surprising fact that any aTAM…

Data Structures and Algorithms · Computer Science 2012-12-20 Erik D. Demaine , Martin L. Demaine , Sándor P. Fekete , Matthew J. Patitz , Robert T. Schweller , Andrew Winslow , Damien Woods

The Tile Automata (TA) model describes self-assembly systems in which monomers can build structures and transition with an adjacent monomer to change their states. This paper shows that seeded TA is a non-committal intrinsically universal…

Cellular Automata and Lattice Gases · Physics 2024-07-17 Tim Gomez , Elise Grizzell , Asher Haun , Ryan Knobel , Tom Peters , Robert Schweller , Tim Wylie

We consider the problem of fault-tolerance in nanoscale algorithmic self-assembly. We employ a variant of Winfree's abstract Tile Assembly Model (aTAM), the two-handed aTAM, in which square "tiles" -- a model of molecules constructed from…

Data Structures and Algorithms · Computer Science 2015-03-14 David Doty , Matthew J. Patitz , Dustin Reishus , Robert T. Schweller , Scott M. Summers

In this paper, we extend existing results about simulation and intrinsic universality in a model of tile-based self-assembly. Namely, we work within the 2-Handed Assembly Model (2HAM), which is a model of self-assembly in which assemblies…

Computational Geometry · Computer Science 2015-03-17 Jacob Hendricks , Matthew J. Patitz , Trent A. Rogers

We present a strict separation between the class of "mismatch free" self-assembly systems and general aTAM systems. Mismatch free systems are those systems in which concurrently grown parts must always agree with each other. Tile…

Computational Geometry · Computer Science 2015-02-20 Florent Becker , Pierre-Étienne Meunier

In the abstract Tile Assembly Model (aTAM), the phenomenon of cooperation occurs when the attachment of a new tile to a growing assembly requires it to bind to more than one tile already in the assembly. Often referred to as…

Emerging Technologies · Computer Science 2014-03-18 Jacob Hendricks , Matthew J. Patitz , Trent A. Rogers

This paper concerns the self-assembly of scaled-up versions of arbitrary finite shapes. We work in the multiple temperature model that was introduced by Aggarwal, Cheng, Goldwasser, Kao, and Schweller (Complexities for Generalized Models of…

Computational Complexity · Computer Science 2009-09-30 Scott M. Summers

Harnessing the intrinsic dynamics of physical systems for information processing opens new avenues for computation embodied in matter. Using simulations of a model system, we show that assemblies of DNA tiles capable of self-organizing into…

Soft Condensed Matter · Physics 2025-10-23 Tim E. Veenstra , René van Roij , Marjolein Dijkstra

We introduce a new property of tile self-assembly systems that we call size-separability. A system is size-separable if every terminal assembly is a constant factor larger than any intermediate assembly. Size-separability is motivated by…

Computational Geometry · Computer Science 2014-04-30 Andrew Winslow

We consider the tile self-assembly model and how tile complexity can be eliminated by permitting the temperature of the self-assembly system to be adjusted throughout the assembly process. To do this, we propose novel techniques for…

Computational Complexity · Computer Science 2007-05-23 Ming-Yang Kao , Robert Schweller