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We propose a mathematical model allowing for the alternating pulse and surge pattern of GnRH (Gonadotropin Releasing Hormone) secretion. The model is based on the coupling between two systems running on different time scales. The faster…

Tissues and Organs · Quantitative Biology 2007-07-12 Frederique Clement , Jean-Pierre Francoise

We demonstrated experimentally canard induced mixed mode oscillations (MMO) in an excitable glow discharge plasma, and the results are validated through numerical solution of the FitzHugh Nagumo (FHN) model. When glow discharge plasma is…

Chaotic Dynamics · Physics 2014-02-26 M. Nurujjaman , A. N. Sekar Iyengar

We investigate a model of the GnRH pulse and surge generator, with the definite aim of constraining the model GnRH output with respect to a physiologically relevant list of specifications. The alternating pulse and surge pattern of…

Dynamical Systems · Mathematics 2009-12-14 Frédérique Clément , Alexandre Vidal

Motivated by the dynamics of neuronal responses, we analyze the dynamics of the Fitzhugh-Nagumo slow-fast system with delayed self-coupling. This system provides a canonical example of a canard explosion for sufficiently small delays.…

Dynamical Systems · Mathematics 2016-02-17 Maciej Krupa , Jonathan Touboul

We study the dynamics of a low-dimensional system of coupled model neurons as a step towards understanding the vastly complex network of neurons in the brain. We analyze the bifurcation structure of a system of two model neurons with…

Dynamical Systems · Mathematics 2019-03-27 Elizabeth N. Davison , Zahra Aminzare , Biswadip Dey , Naomi Ehrich Leonard

In this work, we investigate the spike-adding mechanism in a class of three-dimensional fast-slow systems with three distinct timescales, inspired by the FitzHugh-Nagumo (FHN) model driven by periodic input. First, we numerically generate a…

Dynamical Systems · Mathematics 2025-05-28 Pake Melland , Rodica Curtu , Zahra Aminzare

The multiple time scale dynamics induced by radiation pressure and photothermal effects in a high-finesse optomechanical resonator is experimentally studied. At difference with two-dimensional slow-fast systems, the transition from the…

Mesoscale and Nanoscale Physics · Physics 2013-05-23 Francesco Marino , Francesco Marin

We analyze a biophysical model of a neuron from the entorhinal cortex that includes persistent sodium and slow potassium as non-standard currents using reduction of dimension and dynamical systems techniques to determine the mechanisms for…

Dynamical Systems · Mathematics 2008-04-08 Jozsi Jalics , Martin Krupa , Horacio G. Rotstein

The three-dimensional (3D) Fitzhugh-Nagumo neuron model with inertia was shown to exhibit a chaotic mixed-mode dynamics composed of large-amplitude spikes separated by an irregular number of small-amplitude chaotic oscillations. In contrast…

Adaptation and Self-Organizing Systems · Physics 2023-01-25 Marzena Ciszak , Salvador Balle , Oreste Piro , Francesco Marino

Following the paper of K. Shimizu et al. (2011) we consider the Bonhoeffer-van der Pol oscillator with non-autonomous periodic perturbation. We show that the presence of mixed mode oscillations reported in that paper can be explained using…

Mathematical Physics · Physics 2013-11-21 E. Kutafina

Mixed mode oscillations (MMOs) are complex oscillatory behaviors of multiple-timescale dynamical systems in which there is an alternation of large-amplitude and small-amplitude oscillations. It is well known that MMOs in two-timescale…

Dynamical Systems · Mathematics 2024-03-01 Ngoc Anh Phan , Yangyang Wang

In this paper we prove the existence of a new type of relaxation oscillation occurring in a one-block Burridge-Knopoff model with Ruina rate-and-state friction law. In the relevant parameter regime, the system is slow-fast with two slow…

Dynamical Systems · Mathematics 2019-04-01 K. Uldall Kristiansen

When an oscillator switches abruptly between different frequencies, there is some ambiguity in deciding how the system should be modelled at the switch. Here we describe two seemingly natural models of a switch in a simple…

Dynamical Systems · Mathematics 2022-12-28 Carles Bonet , Mike R. Jeffrey , Pau Martín , Josep M. Olm

In this article, we discuss the dynamics of the 3-dimensional FitzHugh-Rinzel (FHR) model and a class of non-homogeneous FitzHugh-Nagumo (Nh-FHN) Reaction-Diffusion systems. The Nh-FHN models can be used to generate relevant wave…

Pattern Formation and Solitons · Physics 2022-05-10 B. Ambrosio , M. A. Aziz-Alaoui , Argha Mondal , Arnab Mondal , Sanjeev K. Sharma , Ranjit K. Upadhyay

We analyze a piecewise-linear FitzHugh-Nagumo model. The system exhibits a canard near which both small amplitude and large amplitude periodic orbits exist. The addition of small noise induces mixed-mode oscillations (MMOs) in the vicinity…

Dynamical Systems · Mathematics 2015-05-20 David J. W. Simpson , Rachel Kuske

The dynamics of spatiotemporal patterns in oscillatory reaction-diffusion systems subject to periodic forcing with a spatially random forcing amplitude field are investigated. Quenched disorder is studied using the resonantly forced complex…

Pattern Formation and Solitons · Physics 2009-10-31 C. J. Hemming , R. Kapral

Geometrical Singular Perturbation Theory has been successful to investigate a broad range of biological problems with different time scales. The aim of this paper is to apply this theory to a predator-prey model of modified Leslie-Gower…

Dynamical Systems · Mathematics 2017-03-29 B. Ambrosio , M. A. Aziz-Alaoui , R. Yafia

We study two kinetically constrained models in a quenched random environment. The first model is a mixed threshold Fredrickson-Andersen model on $\mathbb{Z}^{2}$, where the update threshold is either $1$ or $2$. The second is a mixture of…

Probability · Mathematics 2020-06-17 Assaf Shapira

Small lattices of $N$ nearest neighbor coupled excitable FitzHugh-Nagumo systems, with time-delayed coupling are studied, and compared with systems of FitzHugh-Nagumo oscillators with the same delayed coupling. Bifurcations of equilibria in…

Chaotic Dynamics · Physics 2009-11-10 Nikola Buric , Dragana Todorovic

This article communicates results on regular depolarization cascades in periodically-kicked feedforward chains of excitable two-dimensional FitzHugh-Nagumo systems driven by sufficiently strong excitatory forcing at the front node. The…

Dynamical Systems · Mathematics 2021-12-21 B. Ambrosio , S. M. Mintchev
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