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Deducing the structure of neural circuits is one of the central problems of modern neuroscience. Recently-introduced calcium fluorescent imaging methods permit experimentalists to observe network activity in large populations of neurons,…

Applications · Statistics 2011-07-22 Yuriy Mishchencko , Joshua T. Vogelstein , Liam Paninski

Integrating the brain structural and functional connectivity features is of great significance in both exploring brain science and analyzing cognitive impairment clinically. However, it remains a challenge to effectively fuse structural and…

Neurons and Cognition · Quantitative Biology 2023-05-25 Qiankun Zuo , Baiying Lei , Ning Zhong , Yi Pan , Shuqiang Wang

Connectomics and network neuroscience offer quantitative scientific frameworks for modeling and analyzing networks of structurally and functionally interacting neurons, neuronal populations, and macroscopic brain areas. This shift in…

Neurons and Cognition · Quantitative Biology 2020-10-06 Richard Betzel

The distributed nature of the neural substrate, and the difficulty of establishing necessity from correlative data, combine to render the mapping of brain function a far harder task than it seems. Methods capable of combining connective…

Connected networks are a fundamental structure of neurobiology. Understanding these networks will help us elucidate the neural mechanisms of computation. Mathematically speaking these networks are `graphs' - structures containing objects…

Neurons and Cognition · Quantitative Biology 2020-10-20 Carl J. Nelson , Stephen Bonner

Understanding the intricate architecture of brain networks and its connection to brain function is essential for deciphering the underlying principles of cognition and disease. While traditional graph-theoretical measures have been widely…

Chaotic Dynamics · Physics 2025-11-13 Anca Radulescu , Eva Kaslik , Alexandru Fikl , Johan Nakuci , Sarah Muldoon , Michael Anderson

Multi-modal neuroimaging technology has greatlly facilitated the efficiency and diagnosis accuracy, which provides complementary information in discovering objective disease biomarkers. Conventional deep learning methods, e.g. convolutional…

Image and Video Processing · Electrical Eng. & Systems 2022-10-26 Yanwu Yang , Xutao Guo , Zhikai Chang , Chenfei Ye , Yang Xiang , Ting Ma

Functional magnetic resonance imaging (fMRI) functional connectivity between brain regions is often computed using parcellations defined by functional or structural atlases. Typically, some kind of voxel averaging is performed to obtain a…

Functional magnetic resonance imaging (fMRI) is a non-invasive and in-vivo imaging technique essential for measuring brain activity. Functional connectivity is used to study associations between brain regions, either while study subjects…

Applications · Statistics 2024-03-26 Kun Meng , Ani Eloyan

With the advances in high resolution neuroimaging, there has been a growing interest in the detection of functional brain connectivity. Complex network theory has been proposed as an attractive mathematical representation of functional…

Neural and Evolutionary Computing · Computer Science 2018-09-18 Arash Golibagh Mahyari , Selin Aviyente

To characterize atypical brain dynamics under diseases, prevalent studies investigate functional magnetic resonance imaging (fMRI). However, most of the existing analyses compress rich spatial-temporal information as the brain functional…

Image and Video Processing · Electrical Eng. & Systems 2023-05-08 Xiaozhao Liu , Mianxin Liu , Lang Mei , Yuyao Zhang , Feng Shi , Han Zhang , Dinggang Shen

Brain connectivity analysis is now at the foreground of neuroscience research. A connectivity network is characterized by a graph, where nodes represent neural elements such as neurons and brain regions, and links represent statistical…

Methodology · Statistics 2015-11-04 Yin Xia , Lexin Li

Contemporary neuroscience has embraced network science to study the complex and self-organized structure of the human brain; one of the main outstanding issues is that of inferring from measure data, chiefly functional Magnetic Resonance…

Optimization and Control · Mathematics 2017-03-31 Giulia Prando , Mattia Zorzi , Alessandra Bertoldo , Alessandro Chiuso

Inferring brain connectivity network and quantifying the significance of interactions between brain regions are of paramount importance in neuroscience. Although there have recently emerged some tests for graph inference based on…

Methodology · Statistics 2019-08-23 Yuting Ye , Yin Xia , Lexin Li

Evaluating the functional relationships between brain regions measured with neuroimaging provides insight into how the brain is sharing information at a macro scale. Many functional connectivity methods have been developed for dynamic…

Applications · Statistics 2015-10-30 David B. Keator , Alexander Ihler

The dispute of how the human brain represents conceptual knowledge has been argued in many scientific fields. Brain imaging studies have shown that the spatial patterns of neural activation in the brain are correlated with thinking about…

Neurons and Cognition · Quantitative Biology 2018-06-15 Subba Reddy Oota , Naresh Manwani , Bapi Raju S

Machine learning provides a valuable tool for analyzing high-dimensional functional neuroimaging data, and is proving effective in predicting various neurological conditions, psychiatric disorders, and cognitive patterns. In functional…

Machine Learning · Computer Science 2024-11-25 Anwar Said , Roza G. Bayrak , Tyler Derr , Mudassir Shabbir , Daniel Moyer , Catie Chang , Xenofon Koutsoukos

Action, cognition, emotion and perception can be mapped in the brain by using set of techniques. Translating unimodal concepts from one modality to another is an important step towards understanding the neural mechanisms. This paper…

Other Computer Science · Computer Science 2012-12-18 Revati Shriram , Dr. M. Sundhararajan , Nivedita Daimiwal

Functional connectivity, as estimated using resting state fMRI, has shown potential in bridging the gap between pathophysiology and cognition. However, clinical use of functional connectivity biomarkers is impeded by unreliable estimates of…

The global functional brain network (graph) is more suitable for characterizing brain states than local analysis of the connectivity of brain regions. Therefore, graph-theoretic approaches are the natural methods to study the brain.…