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Understanding a neural code requires knowledge both of the elementary symbols that transmit information and of the algorithm for translating these symbols into sensory signals or motor actions. We show that these questions can be separated:…

Biological Physics · Physics 2007-05-23 N. Brenner , S. P. Strong , R. Koberle , W. Bialek , R. de Ruyter van Steveninck

How can a microorganism adapt to a variety of environmental conditions despite there exists a limited number of signal transduction machineries? We show that for any growing cells whose gene expression is under stochastic fluctuations,…

Molecular Networks · Quantitative Biology 2015-05-13 Chikara Furusawa , Kunihiko Kaneko

Finding optimal correction of errors in generic stabilizer codes is a computationally hard problem, even for simple noise models. While this task can be simplified for codes with some structure, such as topological stabilizer codes,…

Quantum Physics · Physics 2019-06-05 Nishad Maskara , Aleksander Kubica , Tomas Jochym-O'Connor

Representational drift refers to an unstable mapping between neural activity and input sensory or output behavioral variables. While much work has focused on the effect of representational drift on single, simple external variables, we…

Neurons and Cognition · Quantitative Biology 2026-02-27 Siwei Wang , Elizabeth A de Laittre , Jason MacLean , Stephanie E Palmer

Behavioral changes in animals and humans, as a consequence of an error or a verbal instruction, can be extremely rapid. Improvement in behavioral performances are usually associated in machine learning and reinforcement learning to synaptic…

Neurons and Cognition · Quantitative Biology 2025-03-12 Cristiano Capone , Luca Falorsi

Investigating the mapping between visual stimuli and neural responses in the visual cortex contributes to a deeper understanding of biological visual processing mechanisms. Most existing studies characterize this mapping by training models…

Computational Engineering, Finance, and Science · Computer Science 2025-12-01 Xing Gao , Dazhong Rong , Qinming He

Grid cells in the entorhinal cortex encode the position of an animal in its environment using spatially periodic tuning curves of varying periodicity. Recent experiments established that these cells are functionally organized in discrete…

Neurons and Cognition · Quantitative Biology 2016-01-13 Noga Weiss Mosheiff , Haggai Agmon , Avraham Moriel , Yoram Burak

Neural networks are known to be data hungry and domain sensitive, but it is nearly impossible to obtain large quantities of labeled data for every domain we are interested in. This necessitates the use of domain adaptation strategies. One…

Computation and Language · Computer Science 2019-10-08 Zi-Yi Dou , Xinyi Wang , Junjie Hu , Graham Neubig

Biological visual systems learn from limited experience, unlike deep learning models that rely on millions of training images. What learning principles make this possible? We tested whether efficient coding, the idea that neural…

Computer Vision and Pattern Recognition · Computer Science 2026-05-20 Ananya Passi , Brian S. Robinson , Michael F. Bonner

Brains learn to represent information from a large set of stimuli, typically by weak supervision. Unsupervised learning is therefore a natural approach for exploring the design of biological neural networks and their computations.…

Neurons and Cognition · Quantitative Biology 2025-10-17 Roy Urbach , Elad Schneidman

Unseen shifts in environment dynamics, driven by hidden parameters such as friction or gravity, create a challenge for maintaining safety. We address this challenge by proposing Adaptive Shielding, a framework for safe reinforcement…

Machine Learning · Computer Science 2026-02-03 Minjae Kwon , Tyler Ingebrand , Ufuk Topcu , Lu Feng

Visual attention forms the basis of understanding the visual world. In this work we follow a computational approach to investigate the biological basis of visual attention. We analyze retinal and cortical electrophysiological data from…

Neurons and Cognition · Quantitative Biology 2023-08-02 Nikos Melanitis , Konstantina Nikita

Reinforcement learning (RL) enables adaptive behavior across species via reward prediction errors (RPEs), but the neural origins of species-specific adaptability remain unknown. Integrating RL modeling, transcriptomics, and neuroimaging…

Neurons and Cognition · Quantitative Biology 2025-12-12 Tian Sang , Yichun Huang , Fangwei Zhong , Miao Wang , Shiqi Yu , Jiahui Li , Yuanjing Feng , Yizhou Wang , Kwok Sze Chai , Ravi S. Menon , Meiyun Wang , Fang Fang , Zheng Wang

Since humans still outperform artificial neural networks on many tasks, drawing inspiration from the brain may help to improve current machine learning algorithms. Contrastive Hebbian Learning (CHL) and Equilibrium Propagation (EP) are…

Neural and Evolutionary Computing · Computer Science 2022-05-02 Yoshimasa Kubo , Eric Chalmers , Artur Luczak

Previous studies have demonstrated the importance of the primary sensory cortex for the detection, discrimination and awareness of visual stimuli, but it is unknown how neuronal populations in this area process detected and undetected…

Neurons and Cognition · Quantitative Biology 2015-12-03 Jorrit S. Montijn , Pieter M. Goltstein , Cyriel M. A. Pennartz

Biological systems display impressive capabilities in effectively responding to environmental signals in real time. There is increasing evidence that organisms may indeed be employing near optimal Bayesian calculations in their…

Neurons and Cognition · Quantitative Biology 2010-02-12 Steve Yaeli , Ron Meir

Many membrane channels and receptors exhibit adaptive, or desensitized, response to a strong sustained input stimulus, often supported by protein activity-dependent inactivation. Adaptive response is thought to be related to various…

Molecular Networks · Quantitative Biology 2015-03-13 Tamar Friedlander , Naama Brenner

The activity of neurons within brain circuits has been ubiquitously reported to be correlated. The impact of these correlations on brain function has been extensively investigated. Correlations can in principle increase or decrease the…

Neurons and Cognition · Quantitative Biology 2025-07-24 Miguel Ibáñez-Berganza , Giulio Bondanelli , Stefano Panzeri

Recordings from area V4 of monkeys have revealed that when the focus of attention is on a visual stimulus within the receptive field of a cortical neuron, two distinct changes can occur: The firing rate of the neuron can change and there…

Neurons and Cognition · Quantitative Biology 2007-05-23 Paul H. E. Tiesinga , Jean-Marc Fellous , Emilio Salinas , Jorge V. Jose , Terrence J. Sejnowski

The inductive biases of trained neural networks are difficult to understand and, consequently, to adapt to new settings. We study the inductive biases of linearizations of neural networks, which we show to be surprisingly good summaries of…

Machine Learning · Statistics 2021-04-29 Wesley J. Maddox , Shuai Tang , Pablo Garcia Moreno , Andrew Gordon Wilson , Andreas Damianou