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Two dimensional nuclear magnetic resonance (NMR) spectroscopy is one of the major tools for analysing the chemical structure of organic molecules and proteins. Despite its power, this technique requires long measurement times, which,…

We demonstrate an all-optical method for magnetic sensing of individual molecules in ambient conditions at room temperature. Our approach is based on shallow nitrogen-vacancy (NV) centers near the surface of a diamond crystal, which we use…

Mesoscale and Nanoscale Physics · Physics 2015-06-17 A. O. Sushkov , N. Chisholm , I. Lovchinsky , M. Kubo , P. K. Lo , S. D. Bennett , D. Hunger , A. Akimov , R. L. Walsworth , H. Park , M. D. Lukin

The controlled and coherent manipulation of individual quantum systems is a fundamental key for the development of quantum information processing. The nitrogen-vacancy (NV) color center in diamond is a promising system since its…

Nuclear magnetic resonance imaging (MRI) at the atomic scale offers exciting prospects for determining the structure and function of individual molecules and proteins. Quantum defects in diamond have recently emerged as a promising platform…

Quantum Physics · Physics 2022-04-06 K. S. Cujia , K. Herb , J. Zopes , J. M. Abendroth , C. L. Degen

Optically active spin defects in solids offer promising platforms to investigate nuclear spin clusters with high sensitivity and atomic-site resolution. To leverage near-surface defects for molecular structure analysis in chemical and…

We demonstrate a wide-band all-optical method of nanoscale magnetic resonance (MR) spectroscopy under ambient conditions. Our method relies on cross-relaxation between a probe spin, the electronic spin of a nitrogen-vacancy centre in…

The nitrogen vacancy (NV) center in diamond exhibits spin-dependent fluorescence and long spin coherence times under ambient conditions, enabling applications in quantum information processing and sensing. NV centers near the surface can…

The application of magnetic resonance (MR) spectroscopy at progressively smaller length scales may eventually permit "chemical imaging" of spins at the surfaces of materials and biological complexes. In particular, the negatively charged…

Mesoscale and Nanoscale Physics · Physics 2015-06-18 Hai-Jing Wang , Chang S. Shin , Scott J. Seltzer , Claudia E. Avalos , Alexander Pines , Vikram S. Bajaj

Nuclear magnetic resonance (NMR) spectroscopy has approached the limit of single molecule sensitivity, however the spectral resolution is currently insufficient to obtain detailed information on chemical structure and molecular…

Quantum Physics · Physics 2015-08-19 Xi Kong , Alexander Stark , Jiangfeng Du , Liam P. McGuinness , Fedor Jelezko

A key limitation of electron paramagnetic resonance (EPR), an established and powerful tool for studying atomic-scale biomolecular structure and dynamics is its poor sensitivity, samples containing in excess of 10^12 labeled biomolecules…

Spin defects in solids, such as the nitrogen-vacancy (NV) center in diamond, have emerged as a key tool for detecting nuclear spins at the nanoscale. While active nuclear spin control via radio-frequency (RF) irradiation is often…

Quantum technologies have seen a rapid developmental surge over the last couple of years. Though often overshadowed by quantum computation, quantum sensors show tremendous potential for widespread applications in chemistry and biology. One…

Quantum Physics · Physics 2022-05-30 Robin D. Allert , Karl D. Briegel , Dominik B. Bucher

Nuclear magnetic resonance (NMR) spectroscopy is a widely used tool for chemical analysis and molecular structure identification. Because it typically relies on the weak magnetic fields produced by a small thermal nuclear spin polarization,…

Applied Physics · Physics 2020-06-11 Dominik B. Bucher , David R. Glenn , Hongkun Park , Mikhail D. Lukin , Ronald L. Walsworth

The investigation of biomolecular interactions at the single-molecule level has emerged as a pivotal research area in life science, particularly through optical, mechanical, and electrochemical approaches. Spins existing widely in…

Nuclear magnetic resonance (NMR) spectroscopy is a powerful technique for analyzing the structure and function of molecules, and for performing three-dimensional imaging of the spin density. At the heart of NMR spectrometers is the…

Quantum Physics · Physics 2019-04-15 K. S. Cujia , J. M. Boss , K. Herb , J. Zopes , C. L. Degen

Optically-detected paramagnetic centers in wide-bandgap semiconductors are emerging as a promising platform for nanoscale metrology at room temperature. Of particular interest are applications where the center is used as a probe to…

Mesoscale and Nanoscale Physics · Physics 2015-12-09 Abdelghani Laraoui , Daniela Pagliero , Carlos A. Meriles

New schemes that exploit the unique properties of Nitrogen-Vacancy (NV) centers in diamond are presently being explored as a platform for high-resolution magnetic sensing. Here we focus on the ability of a NV center to monitor an adjacent…

Mesoscale and Nanoscale Physics · Physics 2011-10-12 Abdelghani Laraoui , Jonathan S. Hodges , Colm Ryan , Carlos A. Meriles

Single-cell analysis can unravel functional heterogeneity within cell populations otherwise obscured by ensemble measurements. However, non-invasive techniques that probe chemical entities and their dynamics are still lacking. This…

Applied Physics · Physics 2023-06-14 Nick Ruben Neuling , Robin Derek Allert , Dominik Benjamin Bucher

The isolated electronic spin system of the Nitrogen-Vacancy (NV) centre in diamond offers unique possibilities to be employed as a nanoscale sensor for detection and imaging of weak magnetic fields. Magnetic imaging with nanometric…

Mesoscale and Nanoscale Physics · Physics 2014-08-19 L. Rondin , J. -P. Tetienne , T. Hingant , J. -F. Roch , P. Maletinsky , V. Jacques

The detection of individual molecules and their dynamics has been a long-standing challenge in the field of nanotechnology. In this work, we present a method that utilizes a nitrogen vacancy (NV) center and a dangling-bond on the diamond…

Quantum Physics · Physics 2023-12-15 A. Biteri-Uribarren , P. Alsina-Bolívar , C. Munuera-Javaloy , R. Puebla , J. Casanova