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We construct a coarse-grained (CG) model for dipalmitoylphosphatidylcholine (DPPC)/cholesterol bilayers and apply it to large-scale simulation studies of lipid membranes. Our CG model is a two-dimensional representation of the membrane,…

Soft Condensed Matter · Physics 2009-11-10 Teemu Murtola , Emma Falck , Michael Patra , Mikko Karttunen , Ilpo Vattulainen

Separation of salt ions from seawater using graphene oxide (GO) membrane is an emerging desalination method. Here, we investigate the dynamic behavior of water, sodium, and chloride ions inside GO membrane using a computational approach.…

Chemical Physics · Physics 2021-08-25 One-Sun Lee

In unresolved flow CFD-DEM simulations, the porosity values for each CFD cell are determined using a coarse-graining algorithm. While this approach enables coupled simulations of representative numbers of particles, the influence of the…

Fluid Dynamics · Physics 2022-04-18 Hanqiao Che , Catherine O'Sullivan , Adnan Sufian , Edward Smith

The Eulerian-Lagrangian approach based on Large-Eddy Simulation (LES) is one of the most promising and viable numerical tools to study turbulent dispersed flows when the computational cost of Direct Numerical Simulation (DNS) becomes too…

Fluid Dynamics · Physics 2017-06-02 Alessio Innocenti , Cristian Marchioli , Sergio Chibbaro

Shear transformations (i.e., localised rearrangements of particles resulting in the shear deformation of a small region of the sample) are the building blocks of mesoscale models for the flow of disordered solids. In order to compute the…

Soft Condensed Matter · Physics 2015-06-24 Alexandre Nicolas , Francesco Puosi , Hideyuki Mizuno , Jean-Louis Barrat

Diffusion of particles in complex fluids and gels is difficult to describe and often lies beyond the scope of the classical Stokes-Einstein relation. One of the main lines of research over the past few decades has sought to relate…

Soft Condensed Matter · Physics 2025-12-25 Władysław Sokołowski , Huma Jamil , Karol Makuch

Ionic Liquids feature thermophysical properties that are of interest in solvents, energy storage materials and tenable lubrication applications. Recently, a series of coarse grained (CG) models was developed to investigate…

Soft Condensed Matter · Physics 2020-02-19 Oscar Y. Fajardo , Silvia Di Lecce , Fernando Bresme

We use a coarse-grained molecular dynamics simulation to investigate the interaction between neutral or charged nanoparticles (NPs) and a vesicle consisting of neutral and negatively charged lipids. We focus on the interaction strengths of…

Soft Condensed Matter · Physics 2019-07-25 Naofumi Shimokawa , Hiroaki Ito , Yuji Higuchi

In this work, we review previously developed coarse-grained (CG) particle models for biological membrane and red blood cells (RBCs) and discuss the advantages of the CG particle method over the continuum and atomic simulations on modeling…

Soft Condensed Matter · Physics 2017-07-18 He Li , Hung-yu Chang , Jun Yang , Lu Lu , George Lykotrafitis

We review some recent coarse-graining and multi-scale methods, but also put forward some new ideas for addressing such issues. We find that, if one is guided by nonequilibrium statistical mechanics and thermodynamics, it is possible to…

Soft Condensed Matter · Physics 2009-11-06 Patrick Ilg , Vlasis Mavrantzas , Hans Christian Öttinger

Molecular dynamics (MD) simulation is essential for various scientific domains but computationally expensive. Learning-based force fields have made significant progress in accelerating ab-initio MD simulation but are not fast enough for…

Machine Learning · Computer Science 2023-08-29 Xiang Fu , Tian Xie , Nathan J. Rebello , Bradley D. Olsen , Tommi Jaakkola

Composite of two kinds of grains is modeled in two-dimension and the elasticity is calculated using molecular dynamics method implementing Gear predictor-corrector of fifth order. It has been observed that same composite concentration can…

Soft Condensed Matter · Physics 2014-02-10 Sparisoma Viridi , Widayani , Siti Nurul Khotimah

Coarse-grained (CG) molecular dynamics enables simulations of atomic systems such as biomolecules at timescales inaccessible to all-atom (AA) methods, but existing CG neural potentials trained via force matching capture only the gradient of…

Machine Learning · Computer Science 2026-05-14 Sanya Murdeshwar , Sanjit Shashi , Kevin Bachelor , William Noid , Ashwin Lokapally , Razvan Marinescu

In this work, we address the systematic biases and random errors stemming from finite step sizes encountered in diffusion simulations. We introduce the Effective Geometry Monte Carlo (EG-MC) simulation algorithm which modifies the geometry…

Emerging Technologies · Computer Science 2019-06-26 Fatih Dinc , Leander Thiele , Bayram Cevdet Akdeniz

A brief review of modeling and simulation methods for a study of polymers at interfaces is provided. When studying truly multiscale problems as provided by realistic polymer systems, coarse graining is practically unavoidable. In this…

Soft Condensed Matter · Physics 2009-10-19 Fathollah Varnik , Kurt Binder

Recent developments in vortex particle methods for simulating three-dimensional incompressible flows are presented. A lightweight, dynamic Large-Eddy Simulation model is tested, featuring a dynamic procedure that relies solely on Lagrangian…

Fluid Dynamics · Physics 2026-01-13 Flavio A. C. Martins , Alexander van Zuijlen , Carlos J. Simao Ferreira

We present a systematic study of the self-diffusion coefficient for a fluid of particles interacting via the square-well pair potential by means of molecular dynamics simulations in the canonical (N,V,T) ensemble. The discrete nature of the…

Soft Condensed Matter · Physics 2018-11-14 Alexis Torres-Carbajal , Victor M. Trejos , Luz Adriana Nicasio-Collazo

We present a general approach to isolate chemical reaction mechanism as an independently controllable variable across chemically distinct systems. Modern approaches to reduce the computational expense of molecular dynamics simulations often…

A parameterization strategy for molecular models on the basis of force fields is proposed, which allows a rapid development of models for small molecules by using results from quantum mechanical (QM) ab initio calculations and thermodynamic…

Chemical Physics · Physics 2009-04-22 Bernhard Eckl , Jadran Vrabec , Hans Hasse

The partitioning of small molecules in cell membranes---a key parameter for pharmaceutical applications---typically relies on experimentally-available bulk partitioning coefficients. Computer simulations provide a structural resolution of…

Soft Condensed Matter · Physics 2017-12-04 Roberto Menichetti , Kiran H. Kanekal , Kurt Kremer , Tristan Bereau