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In this work a new way to calculate the multivariate joint entropy is presented. This measure is the basis for a fast information-theoretic based evaluation of gene relevance in a Microarray Gene Expression data context. Its low complexity…

Quantitative Methods · Quantitative Biology 2013-02-08 Fernando González , Lluís A. Belanche

Finite Gaussian mixture models are widely used for model-based clustering of continuous data. Nevertheless, since the number of model parameters scales quadratically with the number of variables, these models can be easily…

Methodology · Statistics 2018-09-25 Michael Fop , Thomas Brendan Murphy , Luca Scrucca

The paper is motivated from clustering problem in high-throughput mixed datasets. Clustering of such datasets can provide much insight into biological associations. An open problem in this context is to simultaneously cluster…

Methodology · Statistics 2018-08-15 Chetkar Jha

New experimental methods make it possible to measure the expression levels of many genes, simultaneously, in snapshots from thousands or even millions of individual cells. Current approaches to analyze these experiments involve clustering…

We consider a network of binary-valued sensors with a fusion center. The fusion center has to perform K-means clustering on the binary data transmitted by the sensors. In order to reduce the amount of data transmitted within the network,…

Information Theory · Computer Science 2018-01-18 Elsa Dupraz

Affymetrix Genechip microarrays are used widely to determine the simultaneous expression of genes in a given biological paradigm. Probes on the Genechip array are atomic entities which by definition are randomly distributed across the array…

Genomics · Quantitative Biology 2009-11-13 Radhakrishnan Nagarajan , Meenakshi Upreti

We propose a novel methodology for feature screening in clustering massive datasets, in which both the number of features and the number of observations can potentially be very large. Taking advantage of a fusion penalization based convex…

Methodology · Statistics 2017-10-05 Trambak Banerjee , Gourab Mukherjee , Peter Radchenko

Gaussian Mixture Models (GMM) have found many applications in density estimation and data clustering. However, the model does not adapt well to curved and strongly nonlinear data. Recently there appeared an improvement called AcaGMM (Active…

Machine Learning · Statistics 2015-02-09 P. Spurek , J. Tabor , P. Markowicz

Genetic data are frequently categorical and have complex dependence structures that are not always well understood. For this reason, clustering and classification based on genetic data, while highly relevant, are challenging statistical…

Methodology · Statistics 2016-06-13 Gabriela Bettella Cybis , Marcio Valk , Silvia Regina Costa Lopes

Quantitative genetic studies that model complex, multivariate phenotypes are important for both evolutionary prediction and artificial selection. For example, changes in gene expression can provide insight into developmental and…

Applications · Statistics 2013-05-03 Daniel E Runcie , Sayan Mukherjee

Model-based clustering is widely used for identifying and distinguishing types of diseases. However, modern biomedical data coming with high dimensions make it challenging to perform the model estimation in traditional cluster analysis. The…

Methodology · Statistics 2025-07-22 Kazeem Kareem , Fan Dai

The identification of sets of co-regulated genes that share a common function is a key question of modern genomics. Bayesian profile regression is a semi-supervised mixture modelling approach that makes use of a response to guide inference…

Analysis of single-cell RNA sequencing data is often conducted through network projections such as coexpression networks, primarily due to the abundant availability of network analysis tools for downstream tasks. However, this approach has…

Quantitative Methods · Quantitative Biology 2025-12-24 Wan He , Daniel I. Bolnick , Samuel V. Scarpino , Tina Eliassi-Rad

We consider the simultaneous clustering of rows and columns of a matrix and more particularly the ability to measure the agreement between two co-clustering partitions. The new criterion we developed is based on the Adjusted Rand Index and…

Applications · Statistics 2020-12-16 Valerie Robert , Yann Vasseur , Vincent Brault

The electroencephalographic (EEG) signals provide highly informative data on brain activities and functions. However, their heterogeneity and high dimensionality may represent an obstacle for their interpretation. The introduction of a…

Neural and Evolutionary Computing · Computer Science 2023-10-26 Aurora Saibene , Francesca Gasparini

High dimensionality in datasets produced by microarray technology presents a challenge for Machine Learning (ML) algorithms, particularly in terms of dimensionality reduction and handling imbalanced sample sizes. To mitigate the explained…

O-RAN testing is becoming increasingly difficult with the exponentially growing number of performance measurements as the system grows more complex, with additional units, interfaces, applications, and possible implementations and…

Signal Processing · Electrical Eng. & Systems 2025-10-06 Anish Pradhan , Lingjia Liu , Harpreet S. Dhillon

In machine learning and data mining, Cluster analysis is one of the most widely used unsupervised learning technique. Philosophy of this algorithm is to find similar data items and group them together based on any distance function in…

Machine Learning · Statistics 2018-10-09 Kumarjit Pathak , Jitin Kapila

Gene regulation is a series of processes that control gene expression and its extent. The connections among genes and their regulatory molecules, usually transcription factors, and a descriptive model of such connections, are known as gene…

Molecular Networks · Quantitative Biology 2017-04-24 Yasser Abduallah , Turki Turki , Kevin Byron , Zongxuan Du , Miguel Cervantes-Cervantes , Jason T. L. Wang

Growth mixture models are an important tool for detecting group structure in repeated measures data. Unlike traditional clustering methods, they explicitly model the repeat measurements on observations, and the statistical framework they…

Methodology · Statistics 2017-10-20 Abby Flynt , Nema Dean