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Chromosome analysis and identification from metaphase images is a critical part of cytogenetics based medical diagnosis. It is mainly used for identifying constitutional, prenatal and acquired abnormalities in the diagnosis of genetic…

Computer Vision and Pattern Recognition · Computer Science 2022-09-13 Amritha S Pallavoor , Prajwal A , Sundareshan TS , Sreekanth K Pallavoor

A difficult step in the process of karyotyping is segmenting chromosomes that touch or overlap. In an attempt to automate the process, previous studies turned to Deep Learning methods, with some formulating the task as a semantic…

Machine Learning · Computer Science 2022-03-25 Daniel Kluvanec , Thomas B. Phillips , Kenneth J. W. McCaffrey , Noura Al Moubayed

In medicine, visualizing chromosomes is important for medical diagnostics, drug development, and biomedical research. Unfortunately, chromosomes often overlap and it is necessary to identify and distinguish between the overlapping…

Computer Vision and Pattern Recognition · Computer Science 2017-12-21 R. Lily Hu , Jeremy Karnowski , Ross Fadely , Jean-Patrick Pommier

This paper presents a method that improve state-of-the-art of the concave point detection methods as a first step to segment overlapping objects on images. It is based on the analysis of the curvature of the objects contour. The method has…

Computer Vision and Pattern Recognition · Computer Science 2022-01-11 Miquel Miró-Nicolau , Biel Moyà-Alcover , Manuel Gonzàlez-Hidalgo , Antoni Jaume-i-Capó

Chromosome karyotype analysis is of great clinical importance in the diagnosis and treatment of diseases, especially for genetic diseases. Since manual analysis is highly time and effort consuming, computer-assisted automatic chromosome…

Computer Vision and Pattern Recognition · Computer Science 2021-03-29 Liye Mei , Yalan Yu , Yueyun Weng , Xiaopeng Guo , Yan Liu , Du Wang , Sheng Liu , Fuling Zhou , Cheng Lei

The accurate segmentation and tracking of cells in microscopy image sequences is an important task in biomedical research, e.g., for studying the development of tissues, organs or entire organisms. However, the segmentation of touching…

Computer Vision and Pattern Recognition · Computer Science 2020-12-10 Tim Scherr , Katharina Löffler , Moritz Böhland , Ralf Mikut

In the effort to aid cytologic diagnostics by establishing automatic single cell screening using high throughput digital holographic microscopy for clinical studies thousands of images and millions of cells are captured. The bottleneck lies…

Image and Video Processing · Electrical Eng. & Systems 2024-10-28 Julia Sistermanns , Ellen Emken , Gregor Weirich , Oliver Hayden , Wolfgang Utschick

In medical imaging, chromosome straightening plays a significant role in the pathological study of chromosomes and in the development of cytogenetic maps. Whereas different approaches exist for the straightening task, typically geometric…

Computer Vision and Pattern Recognition · Computer Science 2021-10-20 Sifan Song , Daiyun Huang , Yalun Hu , Chunxiao Yang , Jia Meng , Fei Ma , Frans Coenen , Jiaming Zhang , Jionglong Su

In this work, we propose a new segmentation algorithm for images containing convex objects present in multiple shapes with a high degree of overlap. The proposed algorithm is carried out in two steps, first we identify the visible contours,…

Computer Vision and Pattern Recognition · Computer Science 2017-11-08 Kumar Abhinav , Jaideep Singh Chauhan , Debasis Sarkar

The poor contrast and the overlapping of cervical cell cytoplasm are the major issues in the accurate segmentation of cervical cell cytoplasm. This paper presents an automated unsupervised cytoplasm segmentation approach which can…

Computer Vision and Pattern Recognition · Computer Science 2018-07-16 Pranav Kumar , S L Happy , Swarnadip Chatterjee , Debdoot Sheet , Aurobinda Routray

Automatic image segmentation becomes very crucial for tumor detection in medical image processing.In general, manual and semi automatic segmentation techniques require more time and knowledge. However these drawbacks had overcome by…

Computer Vision and Pattern Recognition · Computer Science 2016-03-09 D. Anithadevi , K. Perumal

Segmentation of a colour image composed of different kinds of texture regions can be a hard problem, namely to compute for an exact texture fields and a decision of the optimum number of segmentation areas in an image when it contains…

Artificial Intelligence · Computer Science 2007-05-23 Vitorino Ramos , Fernando Muge

Chromosome classification is an important but difficult and tedious task in karyotyping. Previous methods only classify manually segmented single chromosome, which is far from clinical practice. In this work, we propose a detection based…

Computer Vision and Pattern Recognition · Computer Science 2021-08-18 Chunlong Luo , Tianqi Yu , Yufan Luo , Manqing Wang , Fuhai Yu , Yinhao Li , Chan Tian , Jie Qiao , Li Xiao

Pathogenic chromosome abnormalities are very common among the general population. While numerical chromosome abnormalities can be quickly and precisely detected, structural chromosome abnormalities are far more complex and typically require…

Artificial Intelligence · Computer Science 2024-07-12 Juren Li , Fanzhe Fu , Ran Wei , Yifei Sun , Zeyu Lai , Ning Song , Xin Chen , Yang Yang

Structural variants compose the majority of human genetic variation, but are difficult to assess using current genomic sequencing technologies. Optical mapping technologies, which measure the size of chromosomal fragments between labeled…

Quantitative Methods · Quantitative Biology 2019-10-10 Weiwei Li , Jan Hannig , Corbin Jones

When applying automatic analysis of fluorescence or histopathological images of cells, it is necessary to partition, or de-clump, partially overlapping cell nuclei. In this work, I describe a method of partitioning partially overlapping…

Computer Vision and Pattern Recognition · Computer Science 2018-04-13 James Kapaldo

Image segmentation of touching objects plays a key role in providing accurate classification for computer vision technologies. A new line profile based imaging segmentation algorithm has been developed to provide a robust and accurate…

Computer Vision and Pattern Recognition · Computer Science 2017-08-07 Ali Mahdi , Jun Qin

Accurate segmentation of 3-D cell nuclei in microscopy images is essential for the study of nuclear organization, gene expression, and cell morphodynamics. Current image segmentation methods are challenged by the complexity and variability…

Image and Video Processing · Electrical Eng. & Systems 2022-03-18 Sundaresh Ram , Jeffrey J. Rodriguez

Image segmentation plays an essential role in medicine for both diagnostic and interventional tasks. Segmentation approaches are either manual, semi-automated or fully-automated. Manual segmentation offers full control over the quality of…

Computer Vision and Pattern Recognition · Computer Science 2019-03-21 Tomas Sakinis , Fausto Milletari , Holger Roth , Panagiotis Korfiatis , Petro Kostandy , Kenneth Philbrick , Zeynettin Akkus , Ziyue Xu , Daguang Xu , Bradley J. Erickson

This paper presents a new method for automatic quantification of ellipse-like cells in images, an important and challenging problem that has been studied by the computer vision community. The proposed method can be described by two main…

Computer Vision and Pattern Recognition · Computer Science 2012-01-17 Wesley Nunes Gonçalves , Odemir Martinez Bruno
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